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Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 [ Mus musculus (house mouse) ]

Gene ID: 110834, updated on 8-Dec-2022

Summary

Official Symbol
Chrna3provided by MGI
Official Full Name
cholinergic receptor, nicotinic, alpha polypeptide 3provided by MGI
Primary source
MGI:MGI:87887
See related
Ensembl:ENSMUSG00000032303 AllianceGenome:MGI:87887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
(a)3; Acra3; Acra-3; A730007P14Rik
Summary
Enables acetylcholine-gated cation-selective channel activity. Acts upstream of or within several processes, including activation of transmembrane receptor protein tyrosine kinase activity; behavioral response to nicotine; and chemical synaptic transmission. Is integral component of postsynaptic specialization membrane. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse. Is expressed in several structures, including central nervous system; gut; myenteric nerve plexus; paravertebral ganglion; and retina. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 6.2), whole brain E14.5 (RPKM 4.2) and 11 other tissues See more
Orthologs
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Genomic context

See Chrna3 in Genome Data Viewer
Location:
9; 9 B
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (54917401..54933846, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (55010117..55026562, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene hydroxylysine kinase 1 Neighboring gene cDNA sequence AY074887 Neighboring gene proteasome subunit alpha 4 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 5 Neighboring gene cholinergic receptor, nicotinic, beta polypeptide 4 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in acetylcholine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within activation of transmembrane receptor protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within behavioral response to nicotine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in behavioral response to nicotine ISO
Inferred from Sequence Orthology
more info
 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of acetylcholine secretion, neurotransmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to acetylcholine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within synaptic transmission involved in micturition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic transmission involved in micturition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within synaptic transmission, cholinergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of acetylcholine-gated channel complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cholinergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cholinergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in cholinergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in dopaminergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane IC
Inferred by Curator
more info
PubMed 
is_active_in postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
neuronal acetylcholine receptor subunit alpha-3
Names
alpha 3
neuronal nicotinic acetylcholine receptor, alpha 3 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145129.3NP_660111.3  neuronal acetylcholine receptor subunit alpha-3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC156832, AC161264
    Consensus CDS
    CCDS23199.2
    UniProtKB/Swiss-Prot
    Q8BV44
    Related
    ENSMUSP00000034851.6, ENSMUST00000034851.7
    Conserved Domains (2) summary
    TIGR00860
    Location:24490
    LIC; Cation transporter family protein
    cd19016
    Location:29235
    LGIC_ECD_nAChR_A3; extracellular domain of nicotinic acetylcholine receptor subunit alpha 3 (CHRNA3)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    54917401..54933846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)