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DIDO1 death inducer-obliterator 1 [ Homo sapiens (human) ]

Gene ID: 11083, updated on 7-Oct-2018

Summary

Official Symbol
DIDO1provided by HGNC
Official Full Name
death inducer-obliterator 1provided by HGNC
Primary source
HGNC:HGNC:2680
See related
Ensembl:ENSG00000101191 MIM:604140; Vega:OTTHUMG00000032945
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BYE1; DIO1; DATF1; DIDO2; DIDO3; DIO-1; DATF-1; C20orf158; dJ885L7.8
Summary
Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 4.7), spleen (RPKM 4.7) and 25 other tissues See more
Orthologs

Genomic context

See DIDO1 in Genome Data Viewer
Location:
20q13.33
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (62877738..62937952, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61509090..61569304, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene transcription factor like 5 Neighboring gene diphthamide biosynthesis 3 pseudogene 1 Neighboring gene uncharacterized LOC105372717 Neighboring gene ADP ribosylation factor 4 pseudogene 2 Neighboring gene small nucleolar RNA, H/ACA box 117 Neighboring gene GID complex subunit 8 homolog Neighboring gene solute carrier family 17 member 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Meiosis, organism-specific biosystem (from REACTOME)
    Meiosis, organism-specific biosystemDuring meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing...
  • Meiotic synapsis, organism-specific biosystem (from REACTOME)
    Meiotic synapsis, organism-specific biosystemMeiotic synapsis is the stable physical pairing of homologous chromosomes that begins in leptonema of prophase I and lasts until anaphase of prophase I. First, short segments of axial elements form a...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11265, KIAA0333, MGC16140, DKFZp434P1115

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
death-inducer obliterator 1
Names
death-associated transcription factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029496.1 RefSeqGene

    Range
    5001..65215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001193369.1NP_001180298.1  death-inducer obliterator 1 isoform c

    See identical proteins and their annotated locations for NP_001180298.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains a different segment for its 5' UTR, compared to variant 4. Variants 4 and 5 encode the same protein (isoform c).
    Source sequence(s)
    AB002331, AY481572, CK300739, DA506324
    Consensus CDS
    CCDS33506.1
    UniProtKB/Swiss-Prot
    Q9BTC0
    Related
    ENSP00000378752.1, OTTHUMP00000031522, ENST00000395343.5, OTTHUMT00000080091
    Conserved Domains (4) summary
    smart00510
    Location:672773
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    COG5034
    Location:160302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10571163
    SPOC; SPOC domain
  2. NM_001193370.1NP_001180299.1  death-inducer obliterator 1 isoform b

    See identical proteins and their annotated locations for NP_001180299.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains a different 5' UTR segment and a different terminal exon, compared to variant 4. It encodes a protein (isoform b) that has a distinct and shorter C-terminus when it is compared to isoform c. Variants 3 and 6 encode the same protein (isoform c).
    Source sequence(s)
    AB002331, AL035669, AW206895, AY481571, DA506324
    Consensus CDS
    CCDS13508.2
    UniProtKB/Swiss-Prot
    Q9BTC0
    Related
    ENSP00000378749.1, OTTHUMP00000031521, ENST00000395340.5, OTTHUMT00000080090
    Conserved Domains (4) summary
    smart00510
    Location:672773
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    COG5034
    Location:160302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10571163
    SPOC; SPOC domain
  3. NM_022105.4NP_071388.2  death-inducer obliterator 1 isoform a

    See identical proteins and their annotated locations for NP_071388.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has a different segment and lacks most of the 3' coding region, compared to variant 4. The resulting protein (isoform a) has a shorter and distinct C-terminus when it is compared to isoform c. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    AI291497, BC004237, DA294135, DB460917
    Consensus CDS
    CCDS13509.1
    UniProtKB/Swiss-Prot
    Q9BTC0
    Related
    ENSP00000359397.4, OTTHUMP00000031518, ENST00000370371.8, OTTHUMT00000080087
    Conserved Domains (2) summary
    cd15639
    Location:266319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    cl26267
    Location:160302
    ING; Inhibitor of growth proteins N-terminal histone-binding
  4. NM_033081.2NP_149072.2  death-inducer obliterator 1 isoform c

    See identical proteins and their annotated locations for NP_149072.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest protein (isoform c). Variants 4 and 5 encode the same protein.
    Source sequence(s)
    AB002331, AY481572, CK300739, CN348578, CN370112, DA294135
    Consensus CDS
    CCDS33506.1
    UniProtKB/Swiss-Prot
    Q9BTC0
    Related
    ENSP00000266070.4, ENST00000266070.8
    Conserved Domains (4) summary
    smart00510
    Location:672773
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    COG5034
    Location:160302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10571163
    SPOC; SPOC domain
  5. NM_080796.3NP_542986.1  death-inducer obliterator 1 isoform a

    See identical proteins and their annotated locations for NP_542986.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a different 5' UTR segment and lacks most of the 3' coding region, compared to variant 4. The resulting protein (isoform a) has a shorter and distinct C-terminus when it is compared to isoform c. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    AI291497, BC014489, DA506324
    Consensus CDS
    CCDS13509.1
    UniProtKB/Swiss-Prot
    Q9BTC0
    Related
    ENSP00000346692.4, OTTHUMP00000031520, ENST00000354665.8, OTTHUMT00000080089
    Conserved Domains (2) summary
    cd15639
    Location:266319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    cl26267
    Location:160302
    ING; Inhibitor of growth proteins N-terminal histone-binding
  6. NM_080797.3NP_542987.2  death-inducer obliterator 1 isoform b

    See identical proteins and their annotated locations for NP_542987.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a different terminal exon, compared to variant 4. It encodes a protein (isoform b) that has a distinct and shorter C-terminus when it is compared to isoform c. Variants 3 and 6 encode the same protein (isoform c).
    Source sequence(s)
    AB002331, AL035669, AW206895, DA294135
    Consensus CDS
    CCDS13508.2
    UniProtKB/Swiss-Prot
    Q9BTC0
    Conserved Domains (4) summary
    smart00510
    Location:672773
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    COG5034
    Location:160302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10571163
    SPOC; SPOC domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    62877738..62937952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528505.2XP_011526807.1  death-inducer obliterator 1 isoform X1

    See identical proteins and their annotated locations for XP_011526807.1

    Conserved Domains (4) summary
    smart00510
    Location:708809
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    COG5034
    Location:160302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10931199
    SPOC; SPOC domain
  2. XM_011528504.1XP_011526806.1  death-inducer obliterator 1 isoform X1

    See identical proteins and their annotated locations for XP_011526806.1

    Conserved Domains (4) summary
    smart00510
    Location:708809
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    COG5034
    Location:160302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10931199
    SPOC; SPOC domain
  3. XM_011528507.1XP_011526809.1  death-inducer obliterator 1 isoform X1

    See identical proteins and their annotated locations for XP_011526809.1

    Conserved Domains (4) summary
    smart00510
    Location:708809
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    COG5034
    Location:160302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10931199
    SPOC; SPOC domain
  4. XM_011528508.1XP_011526810.1  death-inducer obliterator 1 isoform X1

    See identical proteins and their annotated locations for XP_011526810.1

    Conserved Domains (4) summary
    smart00510
    Location:708809
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    COG5034
    Location:160302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10931199
    SPOC; SPOC domain
  5. XM_011528509.2XP_011526811.1  death-inducer obliterator 1 isoform X2

    See identical proteins and their annotated locations for XP_011526811.1

    UniProtKB/Swiss-Prot
    Q9BTC0
    Conserved Domains (4) summary
    smart00510
    Location:672773
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    COG5034
    Location:160302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10571163
    SPOC; SPOC domain
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