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DIDO1 death inducer-obliterator 1 [ Homo sapiens (human) ]

Gene ID: 11083, updated on 6-Oct-2024

Summary

Official Symbol
DIDO1provided by HGNC
Official Full Name
death inducer-obliterator 1provided by HGNC
Primary source
HGNC:HGNC:2680
See related
Ensembl:ENSG00000101191 MIM:604140; AllianceGenome:HGNC:2680
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BYE1; DIO1; DATF1; DIDO2; DIDO3; DIO-1; DATF-1; C20orf158; dJ885L7.8
Summary
Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 4.7), spleen (RPKM 4.7) and 25 other tissues See more
Orthologs
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Genomic context

See DIDO1 in Genome Data Viewer
Location:
20q13.33
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (62877743..62937904, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (64677856..64738018, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61509095..61569256, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13411 Neighboring gene transcription factor like 5 Neighboring gene diphthamide biosynthesis 3 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13127 Neighboring gene uncharacterized LOC105372717 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61492967-61493621 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61506686-61507340 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61507341-61507994 Neighboring gene Sharpr-MPRA regulatory region 11652 Neighboring gene MPRA-validated peak4302 silencer Neighboring gene ARF GTPase 4 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61517086-61517616 Neighboring gene small nucleolar RNA, H/ACA box 117 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61531289-61532143 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61553829-61554340 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:61556733-61557346 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:61557347-61557960 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61558843-61559691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18219 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13133 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13134 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13135 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61569565-61570233 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61583471-61584300 Neighboring gene GID complex subunit 8 homolog Neighboring gene solute carrier family 17 member 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ11265, KIAA0333, MGC16140, DKFZp434P1115

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
death-inducer obliterator 1
Names
death-associated transcription factor 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029496.1 RefSeqGene

    Range
    16448..65210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001193369.2NP_001180298.1  death-inducer obliterator 1 isoform c

    See identical proteins and their annotated locations for NP_001180298.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains a different segment for its 5' UTR, compared to variant 4. Variants 4 and 5 encode the same protein (isoform c).
    Source sequence(s)
    AB002331, AY481572, CK300739, DA506324
    Consensus CDS
    CCDS33506.1
    UniProtKB/Swiss-Prot
    A8MY65, B9EH82, E1P5I1, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q4VXV8, Q4VXV9, Q96D72, Q9BQW0, Q9BTC0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6
    Related
    ENSP00000378752.1, ENST00000395343.6
    Conserved Domains (4) summary
    smart00510
    Location:672773
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    COG5034
    Location:160302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10571163
    SPOC; SPOC domain
  2. NM_001193370.2NP_001180299.1  death-inducer obliterator 1 isoform b

    See identical proteins and their annotated locations for NP_001180299.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains a different 5' UTR segment and a different terminal exon, compared to variant 4. It encodes a protein (isoform b) that has a distinct and shorter C-terminus when it is compared to isoform c. Variants 3 and 6 encode the same protein (isoform c).
    Source sequence(s)
    AB002331, AL035669, AW206895, AY481571, DA506324
    Consensus CDS
    CCDS13508.2
    UniProtKB/Swiss-Prot
    Q9BTC0
    Related
    ENSP00000378749.1, ENST00000395340.5
    Conserved Domains (4) summary
    smart00510
    Location:672773
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    COG5034
    Location:160302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10571163
    SPOC; SPOC domain
  3. NM_022105.5NP_071388.2  death-inducer obliterator 1 isoform a

    See identical proteins and their annotated locations for NP_071388.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has a different segment and lacks most of the 3' coding region, compared to variant 4. The resulting protein (isoform a) has a shorter and distinct C-terminus when it is compared to isoform c. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    BC004237, DB460917
    Consensus CDS
    CCDS13509.1
    UniProtKB/Swiss-Prot
    Q9BTC0
    Related
    ENSP00000359397.4, ENST00000370371.8
    Conserved Domains (2) summary
    COG5034
    Location:160302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
  4. NM_033081.3NP_149072.2  death-inducer obliterator 1 isoform c

    See identical proteins and their annotated locations for NP_149072.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest protein (isoform c). Variants 4 and 5 encode the same protein.
    Source sequence(s)
    AB002331, AY481572, CK300739, CN348578, CN370112, DA294135
    Consensus CDS
    CCDS33506.1
    UniProtKB/Swiss-Prot
    A8MY65, B9EH82, E1P5I1, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q4VXV8, Q4VXV9, Q96D72, Q9BQW0, Q9BTC0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6
    Related
    ENSP00000266070.4, ENST00000266070.8
    Conserved Domains (4) summary
    smart00510
    Location:672773
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    COG5034
    Location:160302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10571163
    SPOC; SPOC domain
  5. NM_080796.4NP_542986.1  death-inducer obliterator 1 isoform a

    See identical proteins and their annotated locations for NP_542986.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a different 5' UTR segment and lacks most of the 3' coding region, compared to variant 4. The resulting protein (isoform a) has a shorter and distinct C-terminus when it is compared to isoform c. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    BC014489, DA506324
    Consensus CDS
    CCDS13509.1
    UniProtKB/Swiss-Prot
    Q9BTC0
    Related
    ENSP00000346692.4, ENST00000354665.8
    Conserved Domains (2) summary
    COG5034
    Location:160302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
  6. NM_080797.4NP_542987.2  death-inducer obliterator 1 isoform b

    See identical proteins and their annotated locations for NP_542987.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a different terminal exon, compared to variant 4. It encodes a protein (isoform b) that has a distinct and shorter C-terminus when it is compared to isoform c. Variants 3 and 6 encode the same protein (isoform c).
    Source sequence(s)
    AB002331, AL035669, AW206895, DA294135
    Consensus CDS
    CCDS13508.2
    UniProtKB/Swiss-Prot
    Q9BTC0
    Conserved Domains (4) summary
    smart00510
    Location:672773
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    COG5034
    Location:160302
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15639
    Location:266319
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:10571163
    SPOC; SPOC domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    62877743..62937904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    64677856..64738018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152302.1: Suppressed sequence

    Description
    NM_152302.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.