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Etfb electron transferring flavoprotein, beta polypeptide [ Mus musculus (house mouse) ]

Gene ID: 110826, updated on 8-Feb-2024

Summary

Official Symbol
Etfbprovided by MGI
Official Full Name
electron transferring flavoprotein, beta polypeptideprovided by MGI
Primary source
MGI:MGI:106098
See related
Ensembl:ENSMUSG00000004610 AllianceGenome:MGI:106098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610009I16Rik; 2810441H06Rik
Summary
Predicted to enable electron transfer activity. Involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase. Located in mitochondrion. Is expressed in several structures, including alimentary system; cranium; eye; nervous system; and urinary system. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFB (electron transfer flavoprotein subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 182.2), kidney adult (RPKM 139.3) and 28 other tissues See more
Orthologs
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Genomic context

See Etfb in Genome Data Viewer
Location:
7 B3; 7 28.25 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43093496..43107224)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43444072..43457800)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene lens intrinsic membrane protein 2 Neighboring gene natural killer cell group 7 sequence Neighboring gene STARR-positive B cell enhancer ABC_E9689 Neighboring gene claudin domain containing 2 Neighboring gene microRNA 7051 Neighboring gene predicted gene, 39000 Neighboring gene STARR-positive B cell enhancer ABC_E4923 Neighboring gene V-set and immunoglobulin domain containing 10 like Neighboring gene IgLON family member 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables electron transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables electron transfer activity TAS
Traceable Author Statement
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of electron transfer flavoprotein complex ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial electron transfer flavoprotein complex TAS
Traceable Author Statement
more info
PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
electron transfer flavoprotein subunit beta
Names
beta-ETF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026695.3NP_080971.2  electron transfer flavoprotein subunit beta

    See identical proteins and their annotated locations for NP_080971.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AI848359, AK150293, BY292045
    Consensus CDS
    CCDS21171.1
    UniProtKB/Swiss-Prot
    Q810V3, Q9DCW4
    Related
    ENSMUSP00000004729.4, ENSMUST00000004729.5
    Conserved Domains (1) summary
    cd01714
    Location:5210
    ETF_beta; The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an ...

RNA

  1. NR_075104.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA207939, AI848359, BE984117, BY292045

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    43093496..43107224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)