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Pcca propionyl-Coenzyme A carboxylase, alpha polypeptide [ Mus musculus (house mouse) ]

Gene ID: 110821, updated on 23-Apr-2019

Summary

Official Symbol
Pccaprovided by MGI
Official Full Name
propionyl-Coenzyme A carboxylase, alpha polypeptideprovided by MGI
Primary source
MGI:MGI:97499
See related
Ensembl:ENSMUSG00000041650
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C79630
Expression
Ubiquitous expression in kidney adult (RPKM 4.2), liver E18 (RPKM 3.6) and 25 other tissues See more
Orthologs

Genomic context

See Pcca in Genome Data Viewer
Location:
14 E5; 14 65.99 cM
Exon count:
28
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (122484357..122889944)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (122933550..123289166)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33769 Neighboring gene zinc finger protein of the cerebellum 2 Neighboring gene PRELI domain containing 1 pseudogene Neighboring gene asparagine synthetase pseudogene Neighboring gene predicted gene, 46487 Neighboring gene predicted gene, 46489 Neighboring gene RIKEN cDNA 4930594M22 gene Neighboring gene gamma-glutamylamine cyclotransferase Neighboring gene predicted gene, 46488 Neighboring gene transmembrane and tetratricopeptide repeat containing 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
propionyl-CoA carboxylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
mitochondrion HDA PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
propionyl-CoA carboxylase alpha chain, mitochondrial
Names
PCCase subunit alpha
propanoyl-CoA:carbon dioxide ligase subunit alpha
propionyl CoA-carboxylase alpha
NP_659093.2
XP_006518493.1
XP_006518495.1
XP_011243224.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144844.2NP_659093.2  propionyl-CoA carboxylase alpha chain, mitochondrial precursor

    See identical proteins and their annotated locations for NP_659093.2

    Status: VALIDATED

    Source sequence(s)
    AK148002, BY263345
    Consensus CDS
    CCDS27350.1
    UniProtKB/Swiss-Prot
    Q91ZA3
    UniProtKB/TrEMBL
    Q3UGC8
    Related
    ENSMUSP00000038763.6, ENSMUST00000038374.12
    Conserved Domains (5) summary
    cd06850
    Location:657723
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    smart00878
    Location:393500
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    COG4770
    Location:59724
    PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]
    pfam00289
    Location:59167
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02786
    Location:172379
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

RNA

  1. NR_153443.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154683, AC169511, AK148002

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    122484357..122889944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518432.3XP_006518495.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X2

    Conserved Domains (5) summary
    cd06850
    Location:577643
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    smart00878
    Location:313420
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    COG4770
    Location:1644
    PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]
    pfam00289
    Location:187
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02786
    Location:92299
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
  2. XM_006518430.3XP_006518493.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X1

    Conserved Domains (5) summary
    cd06850
    Location:639705
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    smart00878
    Location:393500
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    COG4770
    Location:59706
    PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]
    pfam00289
    Location:59167
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02786
    Location:172379
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
  3. XM_011244922.2XP_011243224.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X3

    Conserved Domains (3) summary
    cd06850
    Location:323389
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    smart00878
    Location:59166
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    cl17255
    Location:1845
    ATP-grasp_4; ATP-grasp domain

RNA

  1. XR_001781088.1 RNA Sequence

  2. XR_383133.3 RNA Sequence

  3. XR_001781087.1 RNA Sequence

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