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Srsf1 serine and arginine-rich splicing factor 1 [ Mus musculus (house mouse) ]

Gene ID: 110809, updated on 18-Dec-2022

Summary

Official Symbol
Srsf1provided by MGI
Official Full Name
serine and arginine-rich splicing factor 1provided by MGI
Primary source
MGI:MGI:98283
See related
Ensembl:ENSMUSG00000018379 AllianceGenome:MGI:98283
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Asf; Sf2; Sfrs1; 1110054N12Rik; 5730507C05Rik; 6330415C05Rik
Summary
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 77.9), CNS E14 (RPKM 62.5) and 27 other tissues See more
Orthologs
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Genomic context

See Srsf1 in Genome Data Viewer
Location:
11 C; 11 52.4 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87937325..87944583)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (88046499..88053757)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene dynein light chain LC8-type 2 Neighboring gene predicted gene, 38610 Neighboring gene vascular endothelial zinc finger 1 Neighboring gene RIKEN cDNA 2210416O15 gene Neighboring gene CUE domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA topoisomerase binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RS domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables mRNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables molecular function regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase B binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within RNA splicing IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac muscle contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to interleukin-17 IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interleukin-17-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-17-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA 5'-splice site recognition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA stabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to P-body IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of RNA splicing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction involved in regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction involved in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of exon-exon junction complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/arginine-rich splicing factor 1
Names
ASF/SF2
pre-mRNA-splicing factor SRp30a
splicing factor, arginine/serine-rich 1 (ASF/SF2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001078167.2NP_001071635.1  serine/arginine-rich splicing factor 1 isoform 2

    See identical proteins and their annotated locations for NP_001071635.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK053674, AK078715, AL593853, CF739274
    Consensus CDS
    CCDS36274.1
    UniProtKB/Swiss-Prot
    Q6PDM2
    Related
    ENSMUSP00000133517.2, ENSMUST00000079866.11
    Conserved Domains (3) summary
    COG0724
    Location:888
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12597
    Location:1790
    RRM1_SRSF1; RNA recognition motif 1 in serine/arginine-rich splicing factor 1 (SRSF1) and similar proteins
    cl17169
    Location:121190
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_173374.4NP_775550.2  serine/arginine-rich splicing factor 1 isoform 1

    See identical proteins and their annotated locations for NP_775550.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK053674, AL593853, CF739274
    Consensus CDS
    CCDS36273.1
    UniProtKB/Swiss-Prot
    Q6PDM2, Q8C1H9
    UniProtKB/TrEMBL
    A0A6P5QKA5
    Related
    ENSMUSP00000120595.3, ENSMUST00000139129.9
    Conserved Domains (2) summary
    cd12597
    Location:1290
    RRM1_SRSF1; RNA recognition motif 1 (RRM1) found in serine/arginine-rich splicing factor 1 (SRSF1) and similar proteins
    cd12767
    Location:113196
    RRM2_SRSF1; RNA recognition motif 2 (RRM2) found in serine/arginine-rich splicing factor 1 (SRSF1) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    87937325..87944583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_388324.4 RNA Sequence