U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tshz1 teashirt zinc finger family member 1 [ Mus musculus (house mouse) ]

Gene ID: 110796, updated on 9-May-2024

Summary

Official Symbol
Tshz1provided by MGI
Official Full Name
teashirt zinc finger family member 1provided by MGI
Primary source
MGI:MGI:1346031
See related
Ensembl:ENSMUSG00000046982 AllianceGenome:MGI:1346031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tsh1; Mtsh1; NY-CO-33; Sdccag33; teashirt1; D18Bwg1409e; 5730407I04Rik
Summary
Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within anterior/posterior pattern specification; middle ear morphogenesis; and soft palate development. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; genitourinary system; and limb. Orthologous to human TSHZ1 (teashirt zinc finger homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 22.0), frontal lobe adult (RPKM 18.6) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tshz1 in Genome Data Viewer
Location:
18 E4; 18 57.53 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (84029752..84105833, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (84011627..84087708, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31707 Neighboring gene predicted gene, 31792 Neighboring gene STARR-positive B cell enhancer ABC_E11664 Neighboring gene prostaglandin reductase 3 Neighboring gene predicted gene, 31854

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA4206

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
teashirt homolog 1
Names
serologically defined colon cancer antigen 3 homolog
serologically defined colon cancer antigen 33

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081300.2NP_001074769.1  teashirt homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_001074769.1

    Status: VALIDATED

    Source sequence(s)
    AC124012
    Consensus CDS
    CCDS37876.1
    UniProtKB/Swiss-Prot
    Q5DTH5, Q6PE60, Q8VD19, Q9JLD5
    Related
    ENSMUSP00000089388.6, ENSMUST00000060303.10
    Conserved Domains (3) summary
    cd00086
    Location:892960
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:248270
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12756
    Location:9761067
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
  2. NM_001364993.1NP_001351922.1  teashirt homolog 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124012, CJ130710
    Consensus CDS
    CCDS89292.1
    UniProtKB/TrEMBL
    A0A494B920
    Conserved Domains (2) summary
    cd00086
    Location:628696
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:4567
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001364994.1NP_001351923.1  teashirt homolog 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124012
    Consensus CDS
    CCDS89292.1
    UniProtKB/TrEMBL
    A0A494B920
    Related
    ENSMUSP00000157454.2, ENSMUST00000175783.3
    Conserved Domains (2) summary
    cd00086
    Location:628696
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:4567
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    84029752..84105833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250275.1XP_030106135.1  teashirt homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5DTH5, Q6PE60, Q8VD19, Q9JLD5
    Conserved Domains (3) summary
    cd00086
    Location:892960
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:248270
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12756
    Location:9761067
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
  2. XM_030250273.1XP_030106133.1  teashirt homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5DTH5, Q6PE60, Q8VD19, Q9JLD5
    Conserved Domains (3) summary
    cd00086
    Location:892960
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:248270
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12756
    Location:9761067
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
  3. XM_030250274.2XP_030106134.1  teashirt homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5DTH5, Q6PE60, Q8VD19, Q9JLD5
    Conserved Domains (3) summary
    cd00086
    Location:892960
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00020
    Location:248270
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12756
    Location:9761067
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)