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Cebpe CCAAT/enhancer binding protein epsilon [ Mus musculus (house mouse) ]

Gene ID: 110794, updated on 18-Sep-2024

Summary

Official Symbol
Cebpeprovided by MGI
Official Full Name
CCAAT/enhancer binding protein epsilonprovided by MGI
Primary source
MGI:MGI:103572
See related
Ensembl:ENSMUSG00000052435 AllianceGenome:MGI:103572
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CRP1; Gm294; C/EBPe; C/EBPepsilon
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within several processes, including defense response to bacterium; macrophage differentiation; and phagocytosis. Predicted to be located in nucleus. Is expressed in bone marrow; liver; lung; and spleen. Orthologous to human CEBPE (CCAAT enhancer binding protein epsilon). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 15.2), liver adult (RPKM 4.7) and 9 other tissues See more
Orthologs
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Genomic context

See Cebpe in Genome Data Viewer
Location:
14 C2; 14 27.9 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54947823..54949604, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54710363..54712174, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ciliated left-right organizer metallopeptidase Neighboring gene predicted gene, 53859 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 Neighboring gene ring finger protein 212B Neighboring gene predicted gene, 17772

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC124002, MGC124003

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CCAAT/enhancer-binding protein epsilon
Names
C/EBP-related protein 1
CCAAT/enhancer binding protein (C/EBP), epsilon

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207131.2NP_997014.1  CCAAT/enhancer-binding protein epsilon

    See identical proteins and their annotated locations for NP_997014.1

    Status: VALIDATED

    Source sequence(s)
    CT009512
    Consensus CDS
    CCDS27100.1
    UniProtKB/Swiss-Prot
    Q32MW9, Q6PZD9
    UniProtKB/TrEMBL
    Q32MW8
    Related
    ENSMUSP00000068927.7, ENSMUST00000064290.8
    Conserved Domains (1) summary
    cd14715
    Location:202262
    bZIP_CEBPE; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein epsilon (CEBPE): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    54947823..54949604 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)