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Adgrv1 adhesion G protein-coupled receptor V1 [ Mus musculus (house mouse) ]

Gene ID: 110789, updated on 8-Dec-2022

Summary

Official Symbol
Adgrv1provided by MGI
Official Full Name
adhesion G protein-coupled receptor V1provided by MGI
Primary source
MGI:MGI:1274784
See related
Ensembl:ENSMUSG00000069170 AllianceGenome:MGI:1274784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mgr1; Gpr98; Mass1; VLGR1; Frings
Summary
Enables several functions, including G-protein alpha-subunit binding activity; adenylate cyclase inhibitor activity; and myosin binding activity. Involved in several processes, including negative regulation of adenylate cyclase activity; positive regulation of bone mineralization; and positive regulation of protein kinase C signaling. Acts upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception of sound; inner ear receptor cell stereocilium organization; and positive regulation of protein kinase A signaling. Located in several cellular components, including periciliary membrane compartment; photoreceptor connecting cilium; and stereocilia ankle link. Part of USH2 complex and stereocilia ankle link complex. Is active in stereocilium. Is expressed in several structures, including brain; eye; neural ectoderm; reproductive system; and spinal cord. Used to study Usher syndrome type 2C. Human ortholog(s) of this gene implicated in Usher syndrome type 2C and familial febrile seizures 4. Orthologous to human ADGRV1 (adhesion G protein-coupled receptor V1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 2.4), whole brain E14.5 (RPKM 1.5) and 4 other tissues See more
Orthologs
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Genomic context

See Adgrv1 in Genome Data Viewer
Location:
13 C2- C3; 13 42.18 cM
Exon count:
95
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (81243187..81781504, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (81095068..81633391, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9330111N05 gene Neighboring gene actin, gamma, cytoplasmic 1 pseudogene Neighboring gene crumbs homolog 1 pseudogene Neighboring gene predicted gene, 32639 Neighboring gene LysM, putative peptidoglycan-binding, domain containing 3 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide G

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables G-protein alpha-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G-protein alpha-subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
enables adenylate cyclase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables adenylate cyclase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables myosin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inner ear receptor cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within inner ear receptor cell stereocilium organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of animal organ identity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within nervous system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nervous system process ISO
Inferred from Sequence Orthology
more info
 
involved_in photoreceptor cell maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein kinase A signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein kinase C signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in self proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sensory perception of light stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of sound IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in visual perception IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within visual perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of USH2 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of USH2 complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in periciliary membrane compartment IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor connecting cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in stereocilia ankle link IDA
Inferred from Direct Assay
more info
PubMed 
part_of stereocilia ankle link complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in stereocilium EXP
Inferred from Experiment
more info
PubMed 
is_active_in stereocilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in stereocilium ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
adhesion G-protein coupled receptor V1
Names
G-protein coupled receptor 98
monogenic audiogenic seizure susceptibility protein 1
monogenic, audiogenic seizure susceptibility 1
neurepin
protein rueda
very large G protein-coupled receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_054053.4NP_473394.3  adhesion G-protein coupled receptor V1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC154583, AC154771, AC154824, CT010447
    Consensus CDS
    CCDS36737.1
    UniProtKB/TrEMBL
    B8JJE0
    Related
    ENSMUSP00000093245.5, ENSMUST00000095585.11
    Conserved Domains (6) summary
    smart00237
    Location:42634351
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    pfam03736
    Location:33923434
    EPTP; EPTP domain
    pfam13385
    Location:13421491
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl02522
    Location:17241804
    Calx-beta; Calx-beta domain
    cl02559
    Location:58455891
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:59086141
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    81243187..81781504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315363.1XP_017170852.1  adhesion G-protein coupled receptor V1 isoform X1

    Conserved Domains (8) summary
    smart00237
    Location:42914379
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:42754511
    caca; sodium/calcium exchanger 1
    cd14964
    Location:59595983
    7tm_GPCRs; TM helix 2 [structural motif]
    pfam03736
    Location:34193460
    EPTP; EPTP domain
    pfam13385
    Location:13691518
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl02522
    Location:50255117
    Calx-beta; Calx-beta domain
    cl02559
    Location:58735919
    GPS; GPCR proteolysis site, GPS, motif
    cl28897
    Location:59406180
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_017315364.2XP_017170853.1  adhesion G-protein coupled receptor V1 isoform X2

    Conserved Domains (8) summary
    smart00237
    Location:42904378
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:42744510
    caca; sodium/calcium exchanger 1
    cd14964
    Location:59585982
    7tm_GPCRs; TM helix 2 [structural motif]
    pfam03736
    Location:34193460
    EPTP; EPTP domain
    pfam13385
    Location:13691518
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl02522
    Location:50245116
    Calx-beta; Calx-beta domain
    cl02559
    Location:58725918
    GPS; GPCR proteolysis site, GPS, motif
    cl28897
    Location:59396179
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. XM_017315365.2XP_017170854.1  adhesion G-protein coupled receptor V1 isoform X3

    Conserved Domains (8) summary
    smart00237
    Location:42644352
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:42484484
    caca; sodium/calcium exchanger 1
    cd14964
    Location:59325956
    7tm_GPCRs; TM helix 2 [structural motif]
    pfam03736
    Location:33923433
    EPTP; EPTP domain
    pfam13385
    Location:13421491
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl02522
    Location:49985090
    Calx-beta; Calx-beta domain
    cl02559
    Location:58465892
    GPS; GPCR proteolysis site, GPS, motif
    cl28897
    Location:59136153
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  4. XM_017315367.3XP_017170856.1  adhesion G-protein coupled receptor V1 isoform X5

    Conserved Domains (8) summary
    smart00237
    Location:35443632
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:35283764
    caca; sodium/calcium exchanger 1
    cd14964
    Location:52125236
    7tm_GPCRs; TM helix 2 [structural motif]
    pfam03736
    Location:26722713
    EPTP; EPTP domain
    pfam13385
    Location:622771
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl02522
    Location:42784370
    Calx-beta; Calx-beta domain
    cl02559
    Location:51265172
    GPS; GPCR proteolysis site, GPS, motif
    cl28897
    Location:51935433
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  5. XM_017315368.2XP_017170857.1  adhesion G-protein coupled receptor V1 isoform X6

    Conserved Domains (8) summary
    smart00237
    Location:32703358
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:32543490
    caca; sodium/calcium exchanger 1
    cd14964
    Location:49384962
    7tm_GPCRs; TM helix 2 [structural motif]
    pfam03736
    Location:23982439
    EPTP; EPTP domain
    pfam13385
    Location:348497
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl02522
    Location:40044096
    Calx-beta; Calx-beta domain
    cl02559
    Location:48524898
    GPS; GPCR proteolysis site, GPS, motif
    cl28897
    Location:49195159
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  6. XM_017315372.2XP_017170861.1  adhesion G-protein coupled receptor V1 isoform X9

    Conserved Domains (7) summary
    smart00237
    Location:19742062
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:19582189
    caca; sodium/calcium exchanger 1
    cd14964
    Location:36423666
    7tm_GPCRs; TM helix 2 [structural motif]
    pfam03736
    Location:11021143
    EPTP; EPTP domain
    cl02522
    Location:27082800
    Calx-beta; Calx-beta domain
    cl02559
    Location:35563602
    GPS; GPCR proteolysis site, GPS, motif
    cl28897
    Location:36233863
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  7. XM_017315366.3XP_017170855.1  adhesion G-protein coupled receptor V1 isoform X4

    Conserved Domains (5) summary
    smart00237
    Location:42914379
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:42754511
    caca; sodium/calcium exchanger 1
    pfam03736
    Location:34193460
    EPTP; EPTP domain
    pfam13385
    Location:13691518
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl02522
    Location:50255117
    Calx-beta; Calx-beta domain
  8. XM_017315370.3XP_017170859.1  adhesion G-protein coupled receptor V1 isoform X7

    Conserved Domains (5) summary
    smart00237
    Location:42914379
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:42754506
    caca; sodium/calcium exchanger 1
    pfam03736
    Location:34193460
    EPTP; EPTP domain
    pfam13385
    Location:13691518
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl02522
    Location:15961688
    Calx-beta; Calx-beta domain
  9. XM_017315371.3XP_017170860.1  adhesion G-protein coupled receptor V1 isoform X8

    Conserved Domains (5) summary
    smart00237
    Location:42914379
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:42754511
    caca; sodium/calcium exchanger 1
    pfam03736
    Location:34193460
    EPTP; EPTP domain
    pfam13385
    Location:13691518
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl02522
    Location:15961688
    Calx-beta; Calx-beta domain

RNA

  1. XR_001780748.3 RNA Sequence

  2. XR_004937933.1 RNA Sequence