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TRIOBP TRIO and F-actin binding protein [ Homo sapiens (human) ]

Gene ID: 11078, updated on 13-Feb-2019

Summary

Official Symbol
TRIOBPprovided by HGNC
Official Full Name
TRIO and F-actin binding proteinprovided by HGNC
Primary source
HGNC:HGNC:17009
See related
Ensembl:ENSG00000100106 MIM:609761
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TARA; TAP68; DFNB28; dJ37E16.4; HRIHFB2122
Summary
This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008]
Expression
Ubiquitous expression in spleen (RPKM 8.0), placenta (RPKM 7.0) and 25 other tissues See more
Orthologs

Genomic context

See TRIOBP in Genome Data Viewer
Location:
22q13.1
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (37696988..37776556)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38092995..38172563)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene galectin 1 Neighboring gene nucleolar protein 12 Neighboring gene uncharacterized LOC102724378 Neighboring gene H1 histone family member 0 Neighboring gene glycine C-acetyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: NOL12

Homology

Clone Names

  • FLJ39315, KIAA1662

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP-Rho binding NAS
Non-traceable Author Statement
more info
PubMed 
actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
myosin II binding NAS
Non-traceable Author Statement
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin modification NAS
Non-traceable Author Statement
more info
PubMed 
auditory receptor cell stereocilium organization IEA
Inferred from Electronic Annotation
more info
 
barbed-end actin filament capping NAS
Non-traceable Author Statement
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
sensory perception of sound IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
focal adhesion HDA PubMed 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
midbody IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TRIO and F-actin-binding protein
Names
protein Tara
tara-like protein
trio-associated repeat on actin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012857.1 RefSeqGene

    Range
    5001..84569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039141.3NP_001034230.1  TRIO and F-actin-binding protein isoform 6

    See identical proteins and their annotated locations for NP_001034230.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents the longest transcript and encodes the longest protein (isoform 6).
    Source sequence(s)
    AW444985, DA790674, DQ228005, Z83844
    Consensus CDS
    CCDS43015.1
    UniProtKB/Swiss-Prot
    Q9H2D6
    Related
    ENSP00000384312.3, ENST00000406386.8
    Conserved Domains (7) summary
    cd13275
    Location:17811895
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:17811887
    PH; PH domain
    pfam09727
    Location:20682203
    CortBP2; Cortactin-binding protein-2
    cd16269
    Location:21732186
    GBP_C; coiled coil [structural motif]
    cl12013
    Location:20652145
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl20817
    Location:21072205
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23748
    Location:21592309
    DUF3585; Protein of unknown function (DUF3585)
  2. NM_007032.5NP_008963.3  TRIO and F-actin-binding protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 6. The resulting isoform (1) has a shorter N-terminus when compared to isoform 6.
    Source sequence(s)
    AW444985, BC003618, BQ880866, DQ228003, Z83844
    Consensus CDS
    CCDS43016.1
    UniProtKB/Swiss-Prot
    Q9H2D6
    Related
    ENSP00000386026.2, ENST00000403663.6
    Conserved Domains (4) summary
    cd13275
    Location:68182
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:68174
    PH; PH domain
    cd16269
    Location:456467
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:394492
    GBP_C; Guanylate-binding protein, C-terminal domain
  3. NM_138632.2NP_619538.2  TRIO and F-actin-binding protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region (compared to variant 6), resulting in a protein that has shorter and distinct N- and C-termini when it is compared to isoform 6.
    Source sequence(s)
    BC003618, BC022200, BQ880866, BU621193
    Consensus CDS
    CCDS33644.1
    UniProtKB/Swiss-Prot
    Q9H2D6
    Related
    ENSP00000495322.1, ENST00000646328.1
    Conserved Domains (2) summary
    cd13275
    Location:68182
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:68174
    PH; PH domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    37696988..37776556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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