Format

Send to:

Choose Destination

HSF2BP heat shock transcription factor 2 binding protein [ Homo sapiens (human) ]

Gene ID: 11077, updated on 6-Sep-2021

Summary

Official Symbol
HSF2BPprovided by HGNC
Official Full Name
heat shock transcription factor 2 binding proteinprovided by HGNC
Primary source
HGNC:HGNC:5226
See related
Ensembl:ENSG00000160207 MIM:604554
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POF19; MEILB2
Summary
HSF2 binding protein (HSF2BP) associates with HSF2. The interaction occurs between the trimerization domain of HSF2 and the amino terminal hydrophilic region of HSF2BP that comprises two leucine zipper motifs. HSF2BP may therefore be involved in modulating HSF2 activation. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 2.8), brain (RPKM 0.5) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See HSF2BP in Genome Data Viewer
Location:
21q22.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (43453987..43659499, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (44949066..45079369, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987302 Neighboring gene SIK1-LINC00319 intergenic CAGE-defined high expression enhancer Neighboring gene long intergenic non-protein coding RNA 319 Neighboring gene uncharacterized LOC102723380 Neighboring gene long intergenic non-protein coding RNA 313 Neighboring gene Sharpr-MPRA regulatory region 13752 Neighboring gene ribosomal protein L31 pseudogene 1 Neighboring gene H2B.S histone 1 Neighboring gene microRNA 6070 Neighboring gene ribosomal RNA processing 1B Neighboring gene RRP1B-PDXK intergenic CAGE-defined mid-level expression enhancer

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.
GeneReviews: Not available
Premature ovarian failure 19
MedGen: CN295867 OMIM: 619245 GeneReviews: Not available
not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair involved in meiotic recombination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in female meiosis I ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in male meiosis I ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol HDA PubMed 

General protein information

Preferred Names
heat shock factor 2-binding protein
Names
meiotic localizer of BRCA2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011491.1 RefSeqGene

    Range
    5006..135309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007031.2NP_008962.1  heat shock factor 2-binding protein

    See identical proteins and their annotated locations for NP_008962.1

    Status: REVIEWED

    Source sequence(s)
    AB007131, AP001050
    Consensus CDS
    CCDS13697.1
    UniProtKB/Swiss-Prot
    O75031
    UniProtKB/TrEMBL
    Q6IAT7
    Related
    ENSP00000291560.2, ENST00000291560.7
    Conserved Domains (1) summary
    cl19764
    Location:47106
    COG6; Conserved oligomeric complex COG6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    43453987..43659499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028269.1XP_016883758.1  heat shock factor 2-binding protein isoform X4

  2. XM_017028268.1XP_016883757.1  heat shock factor 2-binding protein isoform X3

  3. XM_017028270.1XP_016883759.1  heat shock factor 2-binding protein isoform X5

  4. XM_011529445.2XP_011527747.2  heat shock factor 2-binding protein isoform X6

  5. XM_011529443.2XP_011527745.2  heat shock factor 2-binding protein isoform X1

  6. XM_017028271.1XP_016883760.1  heat shock factor 2-binding protein isoform X7

  7. XM_017028267.1XP_016883756.1  heat shock factor 2-binding protein isoform X2

  8. XM_017028272.1XP_016883761.1  heat shock factor 2-binding protein isoform X10

    Conserved Domains (1) summary
    cl19764
    Location:47118
    COG6; Conserved oligomeric complex COG6
  9. XM_011529447.2XP_011527749.1  heat shock factor 2-binding protein isoform X9

    Related
    ENSP00000409585.1, ENST00000443485.1
    Conserved Domains (1) summary
    cl19764
    Location:47118
    COG6; Conserved oligomeric complex COG6
  10. XM_011529446.2XP_011527748.1  heat shock factor 2-binding protein isoform X8

    See identical proteins and their annotated locations for XP_011527748.1

    UniProtKB/Swiss-Prot
    O75031

RNA

  1. XR_937435.1 RNA Sequence

Support Center