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TPPP tubulin polymerization promoting protein [ Homo sapiens (human) ]

Gene ID: 11076, updated on 21-Oct-2018

Summary

Official Symbol
TPPPprovided by HGNC
Official Full Name
tubulin polymerization promoting proteinprovided by HGNC
Primary source
HGNC:HGNC:24164
See related
Ensembl:ENSG00000171368 MIM:608773; Vega:OTTHUMG00000131011
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p24; p25; TPPP1; TPPP/p25; p25alpha
Expression
Biased expression in brain (RPKM 45.7), lung (RPKM 7.7) and 9 other tissues See more
Orthologs

Genomic context

See TPPP in Genome Data Viewer
Location:
5p15.33
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (659862..700727, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (659977..693510, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374607 Neighboring gene uncharacterized LOC105374608 Neighboring gene uncharacterized LOC100996325 Neighboring gene centrosomal protein 72 Neighboring gene uncharacterized LOC101929895 Neighboring gene uncharacterized LOC101929898 Neighboring gene zinc finger DHHC-type containing 11B Neighboring gene uncharacterized LOC101928768

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of tubulin polymerization promoting protein (TPPP) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
microtubule bundle formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule bundle formation IDA
Inferred from Direct Assay
more info
PubMed 
microtubule bundle formation ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule polymerization IDA
Inferred from Direct Assay
more info
PubMed 
microtubule polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein polymerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
colocalizes_with microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with microtubule IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microtubule bundle IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
myelin sheath IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tubulin polymerization-promoting protein
Names
25 kDa brain-specific protein
brain specific protein p25 alpha
glycogen synthase kinase 3 (GSK3) inhibitor p24
p25-alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007030.2NP_008961.1  tubulin polymerization-promoting protein

    See identical proteins and their annotated locations for NP_008961.1

    Status: VALIDATED

    Source sequence(s)
    AB017016, AI796918, AW955330, BQ066916, BU726600, DB478250, DB546894
    Consensus CDS
    CCDS3856.1
    UniProtKB/Swiss-Prot
    O94811
    UniProtKB/TrEMBL
    Q4L233
    Related
    ENSP00000353785.5, OTTHUMP00000161630, ENST00000360578.6, OTTHUMT00000253645
    Conserved Domains (1) summary
    pfam05517
    Location:52207
    p25-alpha; p25-alpha

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    659862..700727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454346.1XP_024310114.1  tubulin polymerization-promoting protein isoform X2

    Conserved Domains (1) summary
    pfam05517
    Location:52207
    p25-alpha; p25-alpha
  2. XM_005248237.3XP_005248294.2  tubulin polymerization-promoting protein isoform X2

    See identical proteins and their annotated locations for XP_005248294.2

    UniProtKB/Swiss-Prot
    O94811
    UniProtKB/TrEMBL
    Q4L233
    Conserved Domains (1) summary
    pfam05517
    Location:52207
    p25-alpha; p25-alpha
  3. XM_017008993.1XP_016864482.1  tubulin polymerization-promoting protein isoform X1

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