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TPPP tubulin polymerization promoting protein [ Homo sapiens (human) ]

Gene ID: 11076, updated on 10-Dec-2024

Summary

Official Symbol
TPPPprovided by HGNC
Official Full Name
tubulin polymerization promoting proteinprovided by HGNC
Primary source
HGNC:HGNC:24164
See related
Ensembl:ENSG00000171368 MIM:608773; AllianceGenome:HGNC:24164
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p24; p25; TPPP1; TPPP/p25; p25alpha
Summary
Enables several functions, including magnesium ion binding activity; microtubule nucleator activity; and protein homodimerization activity. Involved in several processes, including microtubule cytoskeleton organization; negative regulation of tubulin deacetylation; and positive regulation of protein polymerization. Located in several cellular components, including cytoskeleton; mitochondrion; and perinuclear region of cytoplasm. Is active in Golgi apparatus. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in brain (RPKM 45.7), lung (RPKM 7.7) and 9 other tissues See more
Orthologs
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Genomic context

See TPPP in Genome Data Viewer
Location:
5p15.33
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (659862..700727, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (657955..690778, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (659977..693467, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374607 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:570939-571526 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86692/86693 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86701 Neighboring gene uncharacterized LOC105374608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:602876-603376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:603377-603877 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:611378-612308 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:612309-613238 Neighboring gene CEP72 divergent transcript Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:618691-619890 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86736 Neighboring gene centrosomal protein 72 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86741 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:643172-643672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:643673-644173 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86745 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86749/86750 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86753 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86779 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86783 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:669166-669920 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86803 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86807 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86811 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:673521-674090 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86819 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_86823 and experimental_86827 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86831 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86835 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86841/86842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:686929-687430 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:692893-693475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15876 Neighboring gene uncharacterized LOC101929898 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:694389-695267 Neighboring gene NANOG hESC enhancer GRCh37_chr5:708729-709282 Neighboring gene zinc finger DHHC-type containing 11B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:727349-727849 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:752062-752252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:753615-754114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22301 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:758511-759354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:759355-760198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:771879-772522 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:782879-783538 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:785123-785861 Neighboring gene bromodomain containing 9 pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:794321-795181 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:811555-811724 Neighboring gene zinc finger DHHC-type containing 11 Neighboring gene signal peptidase complex subunit 2 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of tubulin polymerization promoting protein (TPPP) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables membrane scission GTPase motor activity IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables microtubule nucleator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in astral microtubule organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule bundle formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule bundle formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microtubule bundle formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in microtubule nucleation by microtubule organizing center IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microtubule polymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microtubule polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in myelin assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of tubulin deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in oligodendrocyte development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein polymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of protein polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of microtubule cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
colocalizes_with microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with microtubule IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microtubule bundle IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
tubulin polymerization-promoting protein
Names
25 kDa brain-specific protein
brain specific protein p25 alpha
glycogen synthase kinase 3 (GSK3) inhibitor p24
p25-alpha

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007030.3NP_008961.1  tubulin polymerization-promoting protein

    See identical proteins and their annotated locations for NP_008961.1

    Status: VALIDATED

    Source sequence(s)
    AB017016, AI796918, AW955330, BQ066916, BU726600, DB478250, DB546894
    Consensus CDS
    CCDS3856.1
    UniProtKB/Swiss-Prot
    O94811
    UniProtKB/TrEMBL
    Q4L233
    Related
    ENSP00000353785.5, ENST00000360578.7
    Conserved Domains (1) summary
    pfam05517
    Location:52207
    p25-alpha; p25-alpha

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    659862..700727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454346.1XP_024310114.1  tubulin polymerization-promoting protein isoform X2

    UniProtKB/Swiss-Prot
    O94811
    UniProtKB/TrEMBL
    Q4L233
    Conserved Domains (1) summary
    pfam05517
    Location:52207
    p25-alpha; p25-alpha
  2. XM_047416674.1XP_047272630.1  tubulin polymerization-promoting protein isoform X2

    UniProtKB/Swiss-Prot
    O94811
    UniProtKB/TrEMBL
    Q4L233
  3. XM_017008993.2XP_016864482.1  tubulin polymerization-promoting protein isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    657955..690778 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351515.1XP_054207490.1  tubulin polymerization-promoting protein isoform X3

  2. XM_054351516.1XP_054207491.1  tubulin polymerization-promoting protein isoform X2

    UniProtKB/Swiss-Prot
    O94811
    UniProtKB/TrEMBL
    Q4L233
  3. XM_054351514.1XP_054207489.1  tubulin polymerization-promoting protein isoform X3

  4. XM_054351513.1XP_054207488.1  tubulin polymerization-promoting protein isoform X3

  5. XM_054351512.1XP_054207487.1  tubulin polymerization-promoting protein isoform X1