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STMN2 stathmin 2 [ Homo sapiens (human) ]

Gene ID: 11075, updated on 13-Feb-2019

Summary

Official Symbol
STMN2provided by HGNC
Official Full Name
stathmin 2provided by HGNC
Primary source
HGNC:HGNC:10577
See related
Ensembl:ENSG00000104435 MIM:600621
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCG10; SCGN10
Summary
This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]
Expression
Biased expression in brain (RPKM 155.5) and adrenal (RPKM 33.4) See more
Orthologs

Genomic context

See STMN2 in Genome Data Viewer
Location:
8q21.13
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (79610814..79666175)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (80523049..80578410)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375915 Neighboring gene uncharacterized LOC105375916 Neighboring gene ribosomal protein L3 pseudogene 9 Neighboring gene uncharacterized LOC107986893 Neighboring gene hes related family bHLH transcription factor with YRPW motif 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34868, FLJ50995

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endosome IEA
Inferred from Electronic Annotation
more info
 
growth cone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
stathmin-2
Names
neuron-specific growth-associated protein
neuronal growth-associated protein (silencer element)
stathmin-like 2
superior cervical ganglia, neural specific 10
superior cervical ganglion-10 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199214.1NP_001186143.1  stathmin-2 isoform 1

    See identical proteins and their annotated locations for NP_001186143.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC016240, AI096716, BQ069488, DC319376
    Consensus CDS
    CCDS56542.1
    UniProtKB/Swiss-Prot
    Q93045
    Related
    ENSP00000429243.1, ENST00000518111.5
    Conserved Domains (1) summary
    pfam00836
    Location:39163
    Stathmin; Stathmin family
  2. NM_007029.3NP_008960.2  stathmin-2 isoform 2

    See identical proteins and their annotated locations for NP_008960.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, which results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC016240, AC025599, AI096716, DC319376
    Consensus CDS
    CCDS43748.1
    UniProtKB/Swiss-Prot
    Q93045
    Related
    ENSP00000220876.6, ENST00000220876.11
    Conserved Domains (1) summary
    pfam00836
    Location:39174
    Stathmin; Stathmin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    79610814..79666175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251142.2XP_005251199.1  stathmin-2 isoform X1

    See identical proteins and their annotated locations for XP_005251199.1

    Conserved Domains (1) summary
    pfam00836
    Location:34169
    Stathmin; Stathmin family
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