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TMEM115 transmembrane protein 115 [ Homo sapiens (human) ]

Gene ID: 11070, updated on 18-Aug-2020

Summary

Official Symbol
TMEM115provided by HGNC
Official Full Name
transmembrane protein 115provided by HGNC
Primary source
HGNC:HGNC:30055
See related
Ensembl:ENSG00000126062 MIM:607069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PL6
Expression
Ubiquitous expression in placenta (RPKM 15.3), kidney (RPKM 14.6) and 25 other tissues See more
Orthologs

Genomic context

See TMEM115 in Genome Data Viewer
Location:
3p21.31
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (50354750..50359521, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (50392180..50396939, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene zinc finger MYND-type containing 10 Neighboring gene cytochrome b561 family member D2 Neighboring gene NPR2 like, GATOR1 complex subunit Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 2 Neighboring gene RNA, 5S ribosomal pseudogene 131 Neighboring gene uncharacterized LOC105377082

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
negative regulation of cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
retrograde vesicle-mediated transport, Golgi to ER IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi cisterna membrane IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
colocalizes_with Golgi transport complex IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transmembrane protein 115
Names
PP6
placental protein 6
testicular tissue protein Li 201

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007024.5NP_008955.1  transmembrane protein 115

    See identical proteins and their annotated locations for NP_008955.1

    Status: VALIDATED

    Source sequence(s)
    BC011948, BF305563, Z84492
    Consensus CDS
    CCDS2828.1
    UniProtKB/Swiss-Prot
    Q12893
    UniProtKB/TrEMBL
    A0A024R2Y2
    Related
    ENSP00000266025.3, ENST00000266025.4
    Conserved Domains (1) summary
    pfam08551
    Location:49151
    DUF1751; Eukaryotic integral membrane protein (DUF1751)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    50354750..50359521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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