Format

Send to:

Choose Destination

CHD3 chromodomain helicase DNA binding protein 3 [ Homo sapiens (human) ]

Gene ID: 1107, updated on 7-Oct-2018

Summary

Official Symbol
CHD3provided by HGNC
Official Full Name
chromodomain helicase DNA binding protein 3provided by HGNC
Primary source
HGNC:HGNC:1918
See related
Ensembl:ENSG00000170004 MIM:602120; Vega:OTTHUMG00000150427
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFH; Mi-2a; Mi2-ALPHA
Summary
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 26.5), brain (RPKM 24.4) and 24 other tissues See more
Orthologs

Genomic context

See CHD3 in Genome Data Viewer
Location:
17p13.1
Exon count:
44
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (7884764..7912757)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7788096..7816075)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 88 Neighboring gene N(alpha)-acetyltransferase 38, NatC auxiliary subunit Neighboring gene cytochrome b5 domain containing 1 Neighboring gene small Cajal body-specific RNA 21 Neighboring gene ring finger protein 227 Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 3 Neighboring gene trafficking protein particle complex 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with CHD3 as demonstrated by proximity dependent biotinylation proteomics PubMed
Tat tat Depletion of CHD3 results in derepression of latent HIV-1 LTR activity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression, organism-specific biosystem (from REACTOME)
    ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression, organism-specific biosystemAbout half of the rRNA genes in the genome are actively expressed, being transcribed by RNA polymerase I (reviewed in Nemeth and Langst 2008, Bartova et al. 2010, Goodfellow and Zomerdijk 2012, Grumm...
  • Epigenetic regulation of gene expression, organism-specific biosystem (from REACTOME)
    Epigenetic regulation of gene expression, organism-specific biosystemEpigenetic processes regulate gene expression by modulating the frequency, rate, or extent of gene expression in a mitotically or meiotically heritable way that does not entail a change in the DNA se...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • HDACs deacetylate histones, organism-specific biosystem (from REACTOME)
    HDACs deacetylate histones, organism-specific biosystemLysine deacetylases (KDACs), historically referred to as histone deacetylases (HDACs), are divided into the Rpd3/Hda1 metal-dependent 'classical HDAC family' (de Ruijter et al. 2003, Verdin et al. 2...
  • Positive epigenetic regulation of rRNA expression, organism-specific biosystem (from REACTOME)
    Positive epigenetic regulation of rRNA expression, organism-specific biosystemTranscription of rRNA genes is controlled by epigenetic activation and repression (reviewed in Percipalle and Farrants 2006, McStay and Grummt 2008, Goodfellow and Zomerdijk 2012, Grummt and Langst 2...
  • RNA Polymerase I Promoter Clearance, organism-specific biosystem (from REACTOME)
    RNA Polymerase I Promoter Clearance, organism-specific biosystemPromoter clearance is one of the rate-limiting steps in Polymerase I transcription. This step is composed of three phases, promoter opening, transcription initiation and promoter escape.
  • RNA Polymerase I Transcription, organism-specific biosystem (from REACTOME)
    RNA Polymerase I Transcription, organism-specific biosystemThe rRNA genes are transcribed by RNA polymerase I, one of three eukaryotic nuclear RNA polymerases. The polymerase is a multisubunit complex, composed of two large subunits (the most conserved porti...
  • RNA Polymerase I Transcription Initiation, organism-specific biosystem (from REACTOME)
    RNA Polymerase I Transcription Initiation, organism-specific biosystemDuring initiation the double-stranded DNA must be melted and transcription begins. SL1 forms and interacts with UBF-1 and the rDNA promoter. It is this platform that will recruit active RNA polymeras...
  • RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, organism-specific biosystem (from REACTOME)
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, organism-specific biosystemTranscription by RNA Polymerase I, RNA Polymerase III and transcription from mitochondrial promoters.
  • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
  • Regulation of TP53 Activity through Acetylation, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity through Acetylation, organism-specific biosystemTranscriptional activity of TP53 is positively regulated by acetylation of several of its lysine residues. BRD7 binds TP53 and promotes acetylation of TP53 lysine residue K382 by acetyltransferase EP...
  • Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by HDAC Class I, organism-specific biosystem
    Signaling events mediated by HDAC Class I
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent DNA helicase activity TAS
Traceable Author Statement
more info
PubMed 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
helicase activity NAS
Non-traceable Author Statement
more info
PubMed 
histone deacetylase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
centrosome cycle IDA
Inferred from Direct Assay
more info
PubMed 
chromatin assembly or disassembly IEA
Inferred from Electronic Annotation
more info
 
histone deacetylation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
spindle organization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
NuRD complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
microtubule organizing center IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
chromodomain-helicase-DNA-binding protein 3
Names
ATP-dependent helicase CHD3
CHD-3
hZFH
mi-2 autoantigen 240 kDa protein
zinc finger helicase
zinc-finger helicase (Snf2-like)
NP_001005271.2
NP_001005273.1
NP_005843.2
XP_005256484.1
XP_005256485.1
XP_005256486.1
XP_005256488.1
XP_006721486.1
XP_006721487.1
XP_006721491.1
XP_016879550.1
XP_016879551.1
XP_016879552.1
XP_016879553.1
XP_016879554.1
XP_016879555.1
XP_016879556.1
XP_016879557.1
XP_016879558.1
XP_016879559.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005271.2NP_001005271.2  chromodomain-helicase-DNA-binding protein 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and CDS, compared to variant 1, resulting in a longer protein (isoform 3) that has a distinct N-terminus, compared to isoform 1. The transcript is supported by ESTs and an mRNA but the predicted protein has not yet been confirmed experimentally.
    Source sequence(s)
    AF064844, AK125928, BC110648, BX283837, CB851648, U91543
    Consensus CDS
    CCDS32553.2
    UniProtKB/Swiss-Prot
    Q12873
    UniProtKB/TrEMBL
    B3KWV4, Q2TAZ1
    Related
    ENSP00000369716.4, OTTHUMP00000197337, ENST00000380358.8, OTTHUMT00000318052
    Conserved Domains (11) summary
    smart00298
    Location:692744
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:9381317
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:815973
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:440482
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:517559
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7981094
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:11181233
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:14371576
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13711415
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:207259
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17951966
    CHDCT2; CHDCT2 (NUC038) domain
  2. NM_001005273.2NP_001005273.1  chromodomain-helicase-DNA-binding protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001005273.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variant 1 encodes isoform 1.
    Source sequence(s)
    AK125928, BC110648, CB851648, U91543
    Consensus CDS
    CCDS32554.1
    UniProtKB/Swiss-Prot
    Q12873
    UniProtKB/TrEMBL
    B3KWV4, Q2TAZ1
    Related
    ENSP00000332628.7, OTTHUMP00000197335, ENST00000330494.11, OTTHUMT00000318050
    Conserved Domains (11) summary
    smart00298
    Location:633685
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:8791258
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:756914
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:381423
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:458500
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7391035
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:10591174
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:13781517
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13121356
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:148200
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17361907
    CHDCT2; CHDCT2 (NUC038) domain
  3. NM_005852.3NP_005843.2  chromodomain-helicase-DNA-binding protein 3 isoform 2

    See identical proteins and their annotated locations for NP_005843.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' CDS, compared to variant 1. The resulting protein (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK125928, BC110648, CB851648, U91543
    Consensus CDS
    CCDS32555.1
    UniProtKB/Swiss-Prot
    Q12873
    UniProtKB/TrEMBL
    B3KWV4, Q2TAZ1
    Related
    ENSP00000350907.4, OTTHUMP00000197336, ENST00000358181.8, OTTHUMT00000318051
    Conserved Domains (12) summary
    PHA03418
    Location:15191654
    PHA03418; hypothetical E4 protein; Provisional
    smart00298
    Location:633685
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:8791258
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:756914
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:381423
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:458500
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7391035
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:10591174
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:13781517
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13121356
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:148200
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17021873
    CHDCT2; CHDCT2 (NUC038) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    7884764..7912757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256427.4XP_005256484.1  chromodomain-helicase-DNA-binding protein 3 isoform X1

    Conserved Domains (11) summary
    smart00298
    Location:692744
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:9381317
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:815973
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:440482
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:517559
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7981094
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:11181233
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:14371576
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13711415
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:207259
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17961923
    CHDCT2; CHDCT2 (NUC038) domain
  2. XM_005256429.4XP_005256486.1  chromodomain-helicase-DNA-binding protein 3 isoform X7

    Conserved Domains (11) summary
    smart00298
    Location:692744
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:9381317
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:815973
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:440482
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:517559
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7981094
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:11181233
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:14371576
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13711415
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:207259
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17961967
    CHDCT2; CHDCT2 (NUC038) domain
  3. XM_006721423.3XP_006721486.1  chromodomain-helicase-DNA-binding protein 3 isoform X2

    Conserved Domains (11) summary
    smart00298
    Location:692744
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:9381317
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:815973
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:440482
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:517559
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7981094
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:11181233
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:14371576
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13711415
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:207259
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17951922
    CHDCT2; CHDCT2 (NUC038) domain
  4. XM_005256428.4XP_005256485.1  chromodomain-helicase-DNA-binding protein 3 isoform X6

    Conserved Domains (12) summary
    PHA03418
    Location:15781713
    PHA03418; hypothetical E4 protein; Provisional
    smart00298
    Location:692744
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:9381317
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:815973
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:440482
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:517559
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7981094
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:11181233
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:14371576
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13711415
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:207259
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17611888
    CHDCT2; CHDCT2 (NUC038) domain
  5. XM_006721428.3XP_006721491.1  chromodomain-helicase-DNA-binding protein 3 isoform X14

    Conserved Domains (12) summary
    PHA03418
    Location:15781713
    PHA03418; hypothetical E4 protein; Provisional
    smart00298
    Location:692744
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:9381317
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:815973
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:440482
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:517559
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7981094
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:11181233
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:14371576
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13711415
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:207259
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17611932
    CHDCT2; CHDCT2 (NUC038) domain
  6. XM_017024065.1XP_016879554.1  chromodomain-helicase-DNA-binding protein 3 isoform X10

  7. XM_017024061.1XP_016879550.1  chromodomain-helicase-DNA-binding protein 3 isoform X4

  8. XM_005256431.4XP_005256488.1  chromodomain-helicase-DNA-binding protein 3 isoform X16

    Conserved Domains (7) summary
    smart00298
    Location:692744
    CHROMO; Chromatin organization modifier domain
    cd00046
    Location:815973
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:440482
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:517559
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7981094
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:11181185
    Helicase_C; Helicase conserved C-terminal domain
    pfam08073
    Location:207259
    CHDNT; CHDNT (NUC034) domain
  9. XM_006721424.3XP_006721487.1  chromodomain-helicase-DNA-binding protein 3 isoform X3

    Conserved Domains (11) summary
    smart00298
    Location:688740
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:9341313
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:811969
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:436478
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:513555
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7941090
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:11141229
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:14331572
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13671411
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:207259
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17921919
    CHDCT2; CHDCT2 (NUC038) domain
  10. XM_017024062.1XP_016879551.1  chromodomain-helicase-DNA-binding protein 3 isoform X5

  11. XM_017024070.1XP_016879559.1  chromodomain-helicase-DNA-binding protein 3 isoform X17

  12. XM_017024064.1XP_016879553.1  chromodomain-helicase-DNA-binding protein 3 isoform X9

  13. XM_017024067.2XP_016879556.1  chromodomain-helicase-DNA-binding protein 3 isoform X12

    Conserved Domains (11) summary
    smart00298
    Location:622674
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:8681247
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:745903
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:370412
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:447489
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7281024
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:10481163
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:13671506
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:13011345
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:137189
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17261853
    CHDCT2; CHDCT2 (NUC038) domain
  14. XM_017024068.1XP_016879557.1  chromodomain-helicase-DNA-binding protein 3 isoform X13

    Conserved Domains (11) summary
    smart00298
    Location:613665
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:8591238
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:736894
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:361403
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:438480
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7191015
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:10391154
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:13581497
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12921336
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:128180
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17171844
    CHDCT2; CHDCT2 (NUC038) domain
  15. XM_017024069.1XP_016879558.1  chromodomain-helicase-DNA-binding protein 3 isoform X15

  16. XM_017024066.1XP_016879555.1  chromodomain-helicase-DNA-binding protein 3 isoform X11

  17. XM_017024063.1XP_016879552.1  chromodomain-helicase-DNA-binding protein 3 isoform X8

Support Center