U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RAPGEF4 Rap guanine nucleotide exchange factor 4 [ Homo sapiens (human) ]

Gene ID: 11069, updated on 3-Dec-2024

Summary

Official Symbol
RAPGEF4provided by HGNC
Official Full Name
Rap guanine nucleotide exchange factor 4provided by HGNC
Primary source
HGNC:HGNC:16626
See related
Ensembl:ENSG00000091428 MIM:606058; AllianceGenome:HGNC:16626
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EPAC; CGEF2; EPAC2; EPAC 2; Nbla00496; CAMP-GEFII
Summary
Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; and regulation of postsynapse organization. Predicted to act upstream of or within with a positive effect on hormone secretion. Predicted to act upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of exocytosis; and secretion by cell. Predicted to be located in membrane. Predicted to be active in several cellular components, including glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density. Implicated in autistic disorder. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in brain (RPKM 37.0), adrenal (RPKM 17.3) and 12 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See RAPGEF4 in Genome Data Viewer
Location:
2q31.1
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (172735318..173052893)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (173221758..173539439)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (173600573..173917621)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56072 Neighboring gene integrin subunit alpha 6 Neighboring gene PDK1 and ITGA6 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 994 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:173399678-173400178 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:173413559-173414301 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:173414302-173415043 Neighboring gene Sharpr-MPRA regulatory region 4236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16763 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12111 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:173456666-173456873 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56189 Neighboring gene pyruvate dehydrogenase kinase 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56221 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56231 Neighboring gene Sharpr-MPRA regulatory region 7042 Neighboring gene small nucleolar RNA U13 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56260 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56279 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56293 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:173577807-173578364 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:173590766-173591266 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:173591267-173591767 Neighboring gene RAPGEF4 antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:173607526-173608725 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:173668092-173668282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:173770903-173771408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:173771409-173771912 Neighboring gene aldehyde dehydrogenase 7 family member A1 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12113 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56377 Neighboring gene mitogen-activated protein kinase kinase kinase 20 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56397 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:174056283-174056864 Neighboring gene MAP3K20 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16764 Neighboring gene VISTA enhancer hs242 Neighboring gene NANOG hESC enhancer GRCh37_chr2:174129200-174129707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16765 Neighboring gene uncharacterized LOC105373743

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag Prostaglandin E2-mediated HIV-1 inhibition requires the EPAC/RAP/RhoA signaling pathway by downregulation of HIV-1 CA production PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cAMP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cAMP binding TAS
Traceable Author Statement
more info
 
enables guanyl-nucleotide exchange factor activity EXP
Inferred from Experiment
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
 
enables small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adaptive immune response TAS
Traceable Author Statement
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium-ion regulated exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of insulin secretion TAS
Traceable Author Statement
more info
 
involved_in regulation of synaptic vesicle cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rap guanine nucleotide exchange factor 4
Names
RAP guanine-nucleotide-exchange factor (GEF) 4
Rap guanine nucleotide exchange factor (GEF) 4
cAMP-regulated guanine nucleotide exchange factor II
exchange factor directly activated by cAMP 2
exchange protein directly activated by cAMP 2
putative protein product of Nbla00496

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100397.2NP_001093867.1  rap guanine nucleotide exchange factor 4 isoform b

    See identical proteins and their annotated locations for NP_001093867.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR, lacks several exons in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC009484, AC019046, AC104086
    Consensus CDS
    CCDS42776.1
    UniProtKB/TrEMBL
    B7Z9P9
    Related
    ENSP00000380276.3, ENST00000397087.7
    Conserved Domains (4) summary
    smart00147
    Location:624865
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:212323
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:62190
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:355461
    RasGEF_N; RasGEF N-terminal motif
  2. NM_001282899.2NP_001269828.1  rap guanine nucleotide exchange factor 4 isoform c

    See identical proteins and their annotated locations for NP_001269828.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR, lacks several exons in the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC009484, AC019046, AC104086
    Consensus CDS
    CCDS63060.1
    UniProtKB/TrEMBL
    B7Z9P9
    Related
    ENSP00000440250.1, ENST00000540783.5
    Conserved Domains (4) summary
    smart00147
    Location:615856
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:203314
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:53181
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:346452
    RasGEF_N; RasGEF N-terminal motif
  3. NM_001282900.2NP_001269829.1  rap guanine nucleotide exchange factor 4 isoform d

    See identical proteins and their annotated locations for NP_001269829.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, lacks several exons in the 5' coding region, initiates translation at a downstream in-frame start codon, and lacks an additional in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC009484, AC019046, AC104086
    Consensus CDS
    CCDS63061.1
    UniProtKB/TrEMBL
    B7Z9P9
    Related
    ENSP00000440135.1, ENST00000538974.5
    Conserved Domains (4) summary
    smart00147
    Location:597838
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:185296
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:35163
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:328434
    RasGEF_N; RasGEF N-terminal motif
  4. NM_001282901.2NP_001269830.1  rap guanine nucleotide exchange factor 4 isoform e

    See identical proteins and their annotated locations for NP_001269830.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR, lacks several exons in the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (e) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC009484, AC019046, AC104086
    Consensus CDS
    CCDS74604.1
    UniProtKB/TrEMBL
    B7Z278, B7Z9P9
    Related
    ENSP00000438011.1, ENST00000535187.5
    Conserved Domains (4) summary
    smart00147
    Location:548789
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:136247
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:1114
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:279385
    RasGEF_N; RasGEF N-terminal motif
  5. NM_001375864.1NP_001362793.1  rap guanine nucleotide exchange factor 4 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC009484, AC018712, AC019046, AC104086
    UniProtKB/TrEMBL
    X5D9F4
    Conserved Domains (4) summary
    cd06224
    Location:494619
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:758999
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:33148
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:196324
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
  6. NM_001375865.1NP_001362794.1  rap guanine nucleotide exchange factor 4 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC009484, AC018712, AC019046, AC104086
    UniProtKB/TrEMBL
    X5D9F4
    Conserved Domains (4) summary
    smart00147
    Location:757998
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:206334
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:499605
    RasGEF_N; RasGEF N-terminal motif
  7. NM_001375866.1NP_001362795.1  rap guanine nucleotide exchange factor 4 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC009484, AC018712, AC019046, AC104086
    UniProtKB/TrEMBL
    X5D7N4, X5D9F4
    Conserved Domains (4) summary
    smart00147
    Location:750991
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:188316
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:481587
    RasGEF_N; RasGEF N-terminal motif
  8. NM_001375867.1NP_001362796.1  rap guanine nucleotide exchange factor 4 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC009484, AC018712, AC019046, AC104086
    UniProtKB/TrEMBL
    X5D9F4
    Conserved Domains (4) summary
    smart00147
    Location:737978
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:325436
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:175303
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:468574
    RasGEF_N; RasGEF N-terminal motif
  9. NM_001375868.1NP_001362797.1  rap guanine nucleotide exchange factor 4 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC009484, AC018712, AC019046, AC104086
    UniProtKB/TrEMBL
    X5D9F4
    Conserved Domains (4) summary
    smart00147
    Location:719960
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:206334
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:499605
    RasGEF_N; RasGEF N-terminal motif
  10. NM_001375869.1NP_001362798.1  rap guanine nucleotide exchange factor 4 isoform k

    Status: VALIDATED

    Source sequence(s)
    AC009484, AC018712, AC019046, AC104086
    UniProtKB/TrEMBL
    X5D9F4
    Conserved Domains (4) summary
    smart00147
    Location:768958
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:206334
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:499605
    RasGEF_N; RasGEF N-terminal motif
  11. NM_001375870.1NP_001362799.1  rap guanine nucleotide exchange factor 4 isoform l

    Status: VALIDATED

    Source sequence(s)
    AC009484, AC018712, AC019046, AC104086
    UniProtKB/TrEMBL
    X5D9F4
    Conserved Domains (4) summary
    smart00147
    Location:768929
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:206334
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:499605
    RasGEF_N; RasGEF N-terminal motif
  12. NM_001375871.1NP_001362800.1  rap guanine nucleotide exchange factor 4 isoform m

    Status: VALIDATED

    Source sequence(s)
    AC009484, AC018712, AC019046, AC104086
    UniProtKB/TrEMBL
    X5D9F4
    Conserved Domains (4) summary
    smart00147
    Location:701942
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:188316
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:481587
    RasGEF_N; RasGEF N-terminal motif
  13. NM_001375872.1NP_001362801.1  rap guanine nucleotide exchange factor 4 isoform n

    Status: VALIDATED

    Source sequence(s)
    AC009484, AC018712, AC019046, AC104086
    Consensus CDS
    CCDS92899.1
    UniProtKB/TrEMBL
    E9PB94, X5D9F4
    Related
    ENSP00000387104.1, ENST00000409036.5
    Conserved Domains (4) summary
    smart00147
    Location:768941
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:206334
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:499605
    RasGEF_N; RasGEF N-terminal motif
  14. NM_001375873.1NP_001362802.1  rap guanine nucleotide exchange factor 4 isoform o

    Status: VALIDATED

    Source sequence(s)
    AC009484, AC018712, AC019046, AC104086
    UniProtKB/TrEMBL
    X5D9F4
    Conserved Domains (4) summary
    smart00147
    Location:750940
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:188316
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:481587
    RasGEF_N; RasGEF N-terminal motif
  15. NM_001375874.1NP_001362803.1  rap guanine nucleotide exchange factor 4 isoform p

    Status: VALIDATED

    Source sequence(s)
    AC009484, AC018712, AC019046, AC104086
    UniProtKB/TrEMBL
    X5D9F4
    Conserved Domains (4) summary
    smart00147
    Location:750911
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:188316
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:481587
    RasGEF_N; RasGEF N-terminal motif
  16. NM_001375875.1NP_001362804.1  rap guanine nucleotide exchange factor 4 isoform q

    Status: VALIDATED

    Source sequence(s)
    AC009484, AC018712, AC104086
    UniProtKB/TrEMBL
    B7Z2Q8
    Conserved Domains (2) summary
    cd00038
    Location:43158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:206334
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
  17. NM_001375876.1NP_001362805.1  rap guanine nucleotide exchange factor 4 isoform r

    Status: VALIDATED

    Source sequence(s)
    AC009484, AC018712, AC104086
    Conserved Domains (2) summary
    cd00038
    Location:43158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:188316
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
  18. NM_007023.4NP_008954.2  rap guanine nucleotide exchange factor 4 isoform a

    See identical proteins and their annotated locations for NP_008954.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC009484, AC018712, AC019046, AC104086
    Consensus CDS
    CCDS42775.1
    UniProtKB/Swiss-Prot
    B2R7R3, B7Z283, B7Z3T6, B7Z912, O95636, Q8IXK6, Q8TAA4, Q8WZA2
    UniProtKB/TrEMBL
    X5D9F4
    Related
    ENSP00000380271.3, ENST00000397081.8
    Conserved Domains (4) summary
    smart00147
    Location:7681009
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:206334
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:499605
    RasGEF_N; RasGEF N-terminal motif

RNA

  1. NR_164739.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009484, AC018712, AC019046, AC104086
  2. NR_164740.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009484, AC018712, AC019046, AC104086
  3. NR_164741.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009484, AC018712, AC019046, AC104086

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    172735318..173052893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443030.1XP_047298986.1  rap guanine nucleotide exchange factor 4 isoform X4

    UniProtKB/TrEMBL
    B7Z9P9
  2. XM_006712205.4XP_006712268.1  rap guanine nucleotide exchange factor 4 isoform X6

    See identical proteins and their annotated locations for XP_006712268.1

    UniProtKB/TrEMBL
    B7Z9P9
    Conserved Domains (4) summary
    smart00147
    Location:597838
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:185296
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:35163
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:328434
    RasGEF_N; RasGEF N-terminal motif
  3. XM_017003196.3XP_016858685.1  rap guanine nucleotide exchange factor 4 isoform X1

    UniProtKB/TrEMBL
    X5D9F4
  4. XM_047443028.1XP_047298984.1  rap guanine nucleotide exchange factor 4 isoform X2

    UniProtKB/TrEMBL
    B7Z9P9
  5. XM_017003197.2XP_016858686.1  rap guanine nucleotide exchange factor 4 isoform X5

    UniProtKB/TrEMBL
    B7Z9P9
  6. XM_047443029.1XP_047298985.1  rap guanine nucleotide exchange factor 4 isoform X3

    UniProtKB/TrEMBL
    B7Z9P9
  7. XM_047443032.1XP_047298988.1  rap guanine nucleotide exchange factor 4 isoform X8

    UniProtKB/TrEMBL
    B7Z9P9
  8. XM_047443033.1XP_047298989.1  rap guanine nucleotide exchange factor 4 isoform X9

    UniProtKB/TrEMBL
    B7Z278, B7Z9P9
  9. XM_047443031.1XP_047298987.1  rap guanine nucleotide exchange factor 4 isoform X7

    UniProtKB/TrEMBL
    B7Z9P9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    173221758..173539439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340254.1XP_054196229.1  rap guanine nucleotide exchange factor 4 isoform X4

    UniProtKB/TrEMBL
    B7Z9P9
  2. XM_054340256.1XP_054196231.1  rap guanine nucleotide exchange factor 4 isoform X6

    UniProtKB/TrEMBL
    B7Z9P9
  3. XM_054340251.1XP_054196226.1  rap guanine nucleotide exchange factor 4 isoform X1

    UniProtKB/TrEMBL
    X5D9F4
  4. XM_054340252.1XP_054196227.1  rap guanine nucleotide exchange factor 4 isoform X2

    UniProtKB/TrEMBL
    B7Z9P9
  5. XM_054340255.1XP_054196230.1  rap guanine nucleotide exchange factor 4 isoform X5

    UniProtKB/TrEMBL
    B7Z9P9
  6. XM_054340253.1XP_054196228.1  rap guanine nucleotide exchange factor 4 isoform X3

    UniProtKB/TrEMBL
    B7Z9P9
  7. XM_054340258.1XP_054196233.1  rap guanine nucleotide exchange factor 4 isoform X8

    UniProtKB/TrEMBL
    B7Z9P9
  8. XM_054340257.1XP_054196232.1  rap guanine nucleotide exchange factor 4 isoform X7

    UniProtKB/TrEMBL
    B7Z9P9
  9. XM_054340259.1XP_054196234.1  rap guanine nucleotide exchange factor 4 isoform X9

    UniProtKB/TrEMBL
    B7Z278, B7Z9P9