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CYB561D2 cytochrome b561 family member D2 [ Homo sapiens (human) ]

Gene ID: 11068, updated on 23-Nov-2021

Summary

Official Symbol
CYB561D2provided by HGNC
Official Full Name
cytochrome b561 family member D2provided by HGNC
Primary source
HGNC:HGNC:30253
See related
Ensembl:ENSG00000114395 Ensembl:ENSG00000271858 MIM:607068
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
101F6; TSP10; XXcos-LUCA11.4
Expression
Ubiquitous expression in lung (RPKM 11.2), colon (RPKM 6.6) and 25 other tissues See more
Orthologs
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Genomic context

See CYB561D2 in Genome Data Viewer
Location:
3p21.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (50350862..50368197)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (50388293..50405628)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene zinc finger MYND-type containing 10 Neighboring gene NPR2 like, GATOR1 complex subunit Neighboring gene transmembrane protein 115 Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 2 Neighboring gene RNA, 5S ribosomal pseudogene 131 Neighboring gene uncharacterized LOC105377082

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane ascorbate ferrireductase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transmembrane monodehydroascorbate reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in ascorbate homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
transmembrane reductase CYB561D2
Names
cytochrome b561 domain-containing protein 2
putative tumor suppressor protein 101F6
transmembrane ascorbate ferrireductase
NP_001278213.1
NP_008953.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291284.2NP_001278213.1  transmembrane reductase CYB561D2

    See identical proteins and their annotated locations for NP_001278213.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the protein.
    Source sequence(s)
    AC002481, AF040704, BC047691
    Consensus CDS
    CCDS2827.1
    UniProtKB/Swiss-Prot
    O14569
    UniProtKB/TrEMBL
    A0A024R342
    Related
    ENSP00000400454.1, ENST00000425346.6
    Conserved Domains (1) summary
    cd08761
    Location:25205
    Cyt_b561_CYB561D2_like; Eukaryotic cytochrome b(561), including the CYB561D2 gene product
  2. NM_007022.5NP_008953.1  transmembrane reductase CYB561D2

    See identical proteins and their annotated locations for NP_008953.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the protein.
    Source sequence(s)
    AC002481, BC047691
    Consensus CDS
    CCDS2827.1
    UniProtKB/Swiss-Prot
    O14569
    UniProtKB/TrEMBL
    A0A024R342
    Related
    ENSP00000232508.5, ENST00000232508.9
    Conserved Domains (1) summary
    cd08761
    Location:25205
    Cyt_b561_CYB561D2_like; Eukaryotic cytochrome b(561), including the CYB561D2 gene product

RNA

  1. NR_111912.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), uses an alternate splice site, lacks two exons, and contains two alternate 3' terminal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AC002481, Z84492
  2. NR_111913.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate promoter and contains a distinct exon structure, compared to variant 1, but includes two exons found in variant 3. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    Z84492
    Related
    ENST00000606665.5
  3. NR_111914.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate promoter and contains a distinct exon structure, compared to variant 1, but includes two exons found in variant 3. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    Z84492

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    50350862..50368197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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