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Rps6ka3 ribosomal protein S6 kinase polypeptide 3 [ Mus musculus (house mouse) ]

Gene ID: 110651, updated on 8-Feb-2024

Summary

Official Symbol
Rps6ka3provided by MGI
Official Full Name
ribosomal protein S6 kinase polypeptide 3provided by MGI
Primary source
MGI:MGI:104557
See related
Ensembl:ENSMUSG00000031309 AllianceGenome:MGI:104557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rsk2; MPK-9; p90RSK3; pp90RSK2; MAPKAPK-1b; S6K-alpha3
Summary
Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in response to lipopolysaccharide and toll-like receptor signaling pathway. Predicted to be located in cytosol and nucleolus. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including alimentary system; blastocyst; branchial arch; central nervous system; and eye. Used to study Coffin-Lowry syndrome. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability 19. Orthologous to human RPS6KA3 (ribosomal protein S6 kinase A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 6.8), genital fat pad adult (RPKM 5.9) and 26 other tissues See more
Orthologs
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Genomic context

See Rps6ka3 in Genome Data Viewer
Location:
X F4; X 73.27 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (158038652..158151240)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (159255665..159368244)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_48166 Neighboring gene ribosomal protein SA pseudogene Neighboring gene STARR-seq mESC enhancer starr_48167 Neighboring gene heat shock protein 90 alpha (cytosolic), class B member 1 pseudogene Neighboring gene eukaryotic translation initiation factor 1A, X-linked Neighboring gene predicted gene 15187

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribosomal protein S6 kinase alpha-3
Names
90 kDa ribosomal protein S6 kinase 3
MAP kinase-activated protein kinase 1b
MAPK-activated protein kinase 1b
MAPKAP kinase 1b
ribosomal protein S6 kinase 2
NP_001333604.1
NP_683747.1
XP_006528750.1
XP_006528751.1
XP_017173843.1
XP_017173844.1
XP_030107056.1
XP_030107058.1
XP_036017675.1
XP_036017676.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346675.1NP_001333604.1  ribosomal protein S6 kinase alpha-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL808146
    Consensus CDS
    CCDS85822.1
    UniProtKB/TrEMBL
    A7E215, B1AXN9
    Conserved Domains (2) summary
    cd05582
    Location:44360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374712
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
  2. NM_148945.2NP_683747.1  ribosomal protein S6 kinase alpha-3 isoform 1

    See identical proteins and their annotated locations for NP_683747.1

    Status: VALIDATED

    Source sequence(s)
    AL808146, AY083469, BC038683, CJ123041
    Consensus CDS
    CCDS30502.1
    UniProtKB/Swiss-Prot
    B1AXN4, P18654, Q03140, Q8K3J8
    UniProtKB/TrEMBL
    A7E215
    Related
    ENSMUSP00000033671.7, ENSMUST00000033671.13
    Conserved Domains (2) summary
    cd05582
    Location:72388
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:402740
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    158038652..158151240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318355.3XP_017173844.1  ribosomal protein S6 kinase alpha-3 isoform X2

    UniProtKB/TrEMBL
    A7E215, B1AXN9
    Conserved Domains (2) summary
    cd05582
    Location:44360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374712
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
  2. XM_030251196.2XP_030107056.1  ribosomal protein S6 kinase alpha-3 isoform X2

    UniProtKB/TrEMBL
    A7E215, B1AXN9
    Related
    ENSMUSP00000108112.2, ENSMUST00000112493.8
    Conserved Domains (2) summary
    cd05582
    Location:44360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374712
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
  3. XM_030251198.2XP_030107058.1  ribosomal protein S6 kinase alpha-3 isoform X2

    UniProtKB/TrEMBL
    A7E215, B1AXN9
    Conserved Domains (2) summary
    cd05582
    Location:44360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374712
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
  4. XM_036161782.1XP_036017675.1  ribosomal protein S6 kinase alpha-3 isoform X1

    UniProtKB/TrEMBL
    A7E215
    Conserved Domains (2) summary
    cd05582
    Location:51367
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:381719
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
  5. XM_006528687.3XP_006528750.1  ribosomal protein S6 kinase alpha-3 isoform X2

    See identical proteins and their annotated locations for XP_006528750.1

    UniProtKB/TrEMBL
    A7E215, B1AXN9
    Conserved Domains (2) summary
    cd05582
    Location:44360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374712
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
  6. XM_017318354.3XP_017173843.1  ribosomal protein S6 kinase alpha-3 isoform X2

    UniProtKB/TrEMBL
    A7E215, B1AXN9
    Conserved Domains (2) summary
    cd05582
    Location:44360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374712
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
  7. XM_036161783.1XP_036017676.1  ribosomal protein S6 kinase alpha-3 isoform X2

    UniProtKB/TrEMBL
    A7E215, B1AXN9
    Conserved Domains (2) summary
    cd05582
    Location:44360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374712
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
  8. XM_006528688.4XP_006528751.1  ribosomal protein S6 kinase alpha-3 isoform X3

    See identical proteins and their annotated locations for XP_006528751.1

    UniProtKB/TrEMBL
    A7E215
    Conserved Domains (2) summary
    cd05582
    Location:43359
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:373711
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)