U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Prps2 phosphoribosyl pyrophosphate synthetase 2 [ Mus musculus (house mouse) ]

Gene ID: 110639, updated on 8-Feb-2024

Summary

Official Symbol
Prps2provided by MGI
Official Full Name
phosphoribosyl pyrophosphate synthetase 2provided by MGI
Primary source
MGI:MGI:97776
See related
Ensembl:ENSMUSG00000025742 AllianceGenome:MGI:97776
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prps-2; 2610101M19Rik
Summary
Predicted to enable several functions, including magnesium ion binding activity; purine ribonucleotide binding activity; and ribose phosphate diphosphokinase activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and AMP biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Is expressed in alimentary system; central nervous system; and retina. Orthologous to human PRPS2 (phosphoribosyl pyrophosphate synthetase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 12.7), genital fat pad adult (RPKM 6.4) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Prps2 in Genome Data Viewer
Location:
X F5; X 78.32 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (166129316..166165887, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (167346320..167382872, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chrX:163766615-163766916 Neighboring gene STARR-seq mESC enhancer starr_48272 Neighboring gene STARR-seq mESC enhancer starr_48273 Neighboring gene STARR-seq mESC enhancer starr_48274 Neighboring gene toll-like receptor 8 Neighboring gene toll-like receptor 7 Neighboring gene predicted gene 15239 Neighboring gene predicted gene, 26368 Neighboring gene predicted gene 6744 Neighboring gene FERM and PDZ domain containing 4 Neighboring gene BTB (POZ) domain containing 10 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC28388

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP binding ISO
Inferred from Sequence Orthology
more info
 
enables AMP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables ribose phosphate diphosphokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ribose phosphate diphosphokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ribose phosphate diphosphokinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ribose phosphate diphosphokinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of ribose phosphate diphosphokinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ribose phosphate diphosphokinase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ribose-phosphate pyrophosphokinase 2
Names
PRS-II
phosphoribosyl pyrophosphate synthase II
phosphoribosyl pyrophosphate synthetase II
NP_001300687.1
NP_080938.1
XP_017173840.1
XP_017173841.1
XP_036017671.1
XP_036017672.1
XP_036017673.1
XP_036017674.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313758.1NP_001300687.1  ribose-phosphate pyrophosphokinase 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK029690, AL731735, AV467400, BY127801, CF733337
    UniProtKB/TrEMBL
    Q3TI27, Q3UPD5
    Conserved Domains (3) summary
    COG0462
    Location:1316
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
    pfam13793
    Location:4123
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    cl00309
    Location:164316
    PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain
  2. NM_026662.5NP_080938.1  ribose-phosphate pyrophosphokinase 2 isoform 2

    See identical proteins and their annotated locations for NP_080938.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 5' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK029690, AL731735, AV467400, BY127801
    Consensus CDS
    CCDS30532.1
    UniProtKB/Swiss-Prot
    Q9CS42, Q9CZA9
    UniProtKB/TrEMBL
    Q3TI27, Q3UPD5
    Related
    ENSMUSP00000026839.5, ENSMUST00000026839.5
    Conserved Domains (3) summary
    COG0462
    Location:1313
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
    pfam13793
    Location:4120
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    cl00309
    Location:161313
    PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    166129316..166165887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161779.1XP_036017672.1  ribose-phosphate pyrophosphokinase 2 isoform X2

    Conserved Domains (1) summary
    COG0462
    Location:189461
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
  2. XM_036161778.1XP_036017671.1  ribose-phosphate pyrophosphokinase 2 isoform X1

    Conserved Domains (1) summary
    COG0462
    Location:189464
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
  3. XM_036161781.1XP_036017674.1  ribose-phosphate pyrophosphokinase 2 isoform X4

    Conserved Domains (1) summary
    pfam13793
    Location:189251
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
  4. XM_036161780.1XP_036017673.1  ribose-phosphate pyrophosphokinase 2 isoform X3

    Conserved Domains (1) summary
    pfam13793
    Location:189250
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
  5. XM_017318352.3XP_017173841.1  ribose-phosphate pyrophosphokinase 2 isoform X6

    Conserved Domains (1) summary
    pfam13793
    Location:85184
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
  6. XM_017318351.3XP_017173840.1  ribose-phosphate pyrophosphokinase 2 isoform X5

    Conserved Domains (1) summary
    pfam13793
    Location:85183
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase