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DUS4L dihydrouridine synthase 4 like [ Homo sapiens (human) ]

Gene ID: 11062, updated on 5-Jan-2022

Summary

Official Symbol
DUS4Lprovided by HGNC
Official Full Name
dihydrouridine synthase 4 likeprovided by HGNC
Primary source
HGNC:HGNC:21517
See related
Ensembl:ENSG00000105865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUS4; PP35
Summary
Predicted to enable tRNA dihydrouridine synthase activity. Predicted to be involved in tRNA dihydrouridine synthesis. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in thyroid (RPKM 3.2), testis (RPKM 2.8) and 25 other tissues See more
Orthologs
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Genomic context

See DUS4L in Genome Data Viewer
Location:
7q22.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (107563971..107578523)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (107204416..107218968)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene component of oligomeric golgi complex 5 Neighboring gene ribosomal protein L37a pseudogene 6 Neighboring gene G protein-coupled receptor 22 Neighboring gene DUS4L-BCAP29 readthrough Neighboring gene B cell receptor associated protein 29 Neighboring gene WBP1L pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough DUS4L-BCAP29

Readthrough gene: DUS4L-BCAP29, Included gene: BCAP29

Homology

Clone Names

  • MGC133233

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in tRNA dihydrouridine synthesis IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like
Names
protein similar to E.coli yhdg and R. capsulatus nifR3
NP_001257348.1
NP_853559.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270419.2NP_001257348.1  tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like

    See identical proteins and their annotated locations for NP_001257348.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA157330, BC111774, BU621752, BX395100, CX787147, DB196544
    Consensus CDS
    CCDS5745.1
    UniProtKB/Swiss-Prot
    O95620
    UniProtKB/TrEMBL
    A4D0R5
    Conserved Domains (1) summary
    cd02801
    Location:28257
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
  2. NM_181581.3NP_853559.1  tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like

    See identical proteins and their annotated locations for NP_853559.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is protein-coding. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA157330, BU621752, BX357552, DA133130, U62767
    Consensus CDS
    CCDS5745.1
    UniProtKB/Swiss-Prot
    O95620
    UniProtKB/TrEMBL
    A4D0R5
    Related
    ENSP00000265720.3, ENST00000265720.8
    Conserved Domains (1) summary
    cd02801
    Location:28257
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

RNA

  1. NR_073002.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA157330, AK297195, BU621752, DB196544
  2. NR_073003.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA157330, AL523141, BC111774, BU621752, DA133130
  3. NR_073004.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an internal exon and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA157330, AK294095, BU621752
  4. NR_073005.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an internal exon and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA157330, AL529385, BC111774, BU621752, DA223301, DB196544

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    107563971..107578523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_017852930.1 Reference GRCh38.p13 PATCHES

    Range
    409626..424178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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