Hdlbp high density lipoprotein (HDL) binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hdlbpprovided by MGI
Official Full Name: high density lipoprotein (HDL) binding proteinprovided by MGI
Primary source: MGI:MGI:99256
See related: Ensembl:ENSMUSG00000034088 AllianceGenome:MGI:99256
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D1Ertd101e; 1110005P14Rik
Summary: Predicted to enable mRNA binding activity. Predicted to act upstream of or within cholesterol metabolic process and lipid transport. Predicted to be located in cytosol. Predicted to be part of polysome. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; female reproductive system; male reproductive system; ovary; and testis. Orthologous to human HDLBP (high density lipoprotein binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 70.8), limb E14.5 (RPKM 50.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 47.24 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (93333662..93406639, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (93405940..93478917, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.
Title: HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Ertd101e (e-PCR), detects polymorphism
- UniSTS:167260

BB136667 (e-PCR)
- UniSTS:185447

AA960365 (e-PCR)
- UniSTS:158832

AI118566 (e-PCR)
- UniSTS:158833

03.MMHAP94FRA9.seq (e-PCR)
- UniSTS:122757

Hdlbp (e-PCR), detects polymorphism
- UniSTS:479117

AI009079 (e-PCR)
- UniSTS:243391

RH101 (e-PCR)
- UniSTS:1002

Homology

Orthologs from Annotation Pipeline: 500 organisms have orthologs with human gene Hdlbp
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of polysome	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: vigilin

Names: HDL-binding protein; high density lipoprotein-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.