LY6G6F-LY6G6D LY6G6F-LY6G6D readthrough [Homo sapiens (human)] - Gene

Summary

Official Symbol: LY6G6F-LY6G6Dprovided by HGNC
Official Full Name: LY6G6F-LY6G6D readthroughprovided by HGNC
Primary source: HGNC:HGNC:38821
See related: Ensembl:ENSG00000250641 AllianceGenome:HGNC:38821
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MEGT1; MEGT-1; G6F-LY6G6D
Summary: This locus represents naturally occurring readthrough transcription between the neighboring LY6G6F (lymphocyte antigen 6 family member G6F) and LY6G6D (lymphocyte antigen 6 family member G6D) genes on chromosome 6. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jul 2017]
Orthologs: all
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Genomic context

Location:: 6p21.33

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (31706866..31717919)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (31559901..31570952)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (31674643..31685696)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

General gene information

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Homology

Orthologs from Annotation Pipeline: 4 organisms have orthologs with human gene LY6G6F-LY6G6D
Orthologs

General protein information

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Preferred Names: LY6G6F-LY6G6D protein

Names: megakaryocyte-enhanced gene transcript 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001353334.2 → NP_001340263.1 LY6G6F-LY6G6D protein precursor

Status: VALIDATED

Source sequence(s)

AL662899, KU253636

Consensus CDS

CCDS87383.1

UniProtKB/TrEMBL

A0A1L6ZA96

Related

ENSP00000421232.1, ENST00000503322.1

Conserved Domains (1) summary

cl11960
Location:25 → 126

Ig; Immunoglobulin domain