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DDX52 DExD-box helicase 52 [ Homo sapiens (human) ]

Gene ID: 11056, updated on 5-Jan-2022

Summary

Official Symbol
DDX52provided by HGNC
Official Full Name
DExD-box helicase 52provided by HGNC
Primary source
HGNC:HGNC:20038
See related
Ensembl:ENSG00000278053 MIM:612500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ROK1; HUSSY19
Summary
Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA. Located in membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in testis (RPKM 4.2), endometrium (RPKM 4.1) and 25 other tissues See more
Orthologs
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Genomic context

See DDX52 in Genome Data Viewer
Location:
17q12
Exon count:
16
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (37609739..37643448, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (35969787..36003475, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 14 Neighboring gene synergin gamma Neighboring gene uncharacterized LOC105371755 Neighboring gene microRNA 378j Neighboring gene uncharacterized LOC105371756 Neighboring gene uncharacterized LOC107985009 Neighboring gene HNF1 homeobox B Neighboring gene uncharacterized LOC105371754

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
siRNA knockdown of DDX52 decreases intra- and extra-cellular HIV CA(p24) from HeLa cells transfected with env-deleted HIV-1 plasmid, a vesicular stomatitis virus glycoprotein plasmid and specific siRNA. Resulting HIV demonstrates decreased infectivity. PubMed

Protein interactions

Protein Gene Interaction Pubs
capsid gag siRNA knockdown of DDX52 decreases intra- and extra-cellular HIV CA(p24) from HeLa cells transfected with env-deleted HIV-1 plasmid, a vesicular stomatitis virus glycoprotein plasmid and specific siRNA. Resulting HIV demonstrates decreased infectivity. PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in membrane HDA PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DDX52
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DEAD box protein 52
DEAD-box helicase 52
NP_001278405.1
NP_008941.3
XP_011522534.1
XP_011522535.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291476.2NP_001278405.1  probable ATP-dependent RNA helicase DDX52 isoform 2

    See identical proteins and their annotated locations for NP_001278405.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC243585, AK001245, AK001652, AK025721, BX492013
    UniProtKB/Swiss-Prot
    Q9Y2R4
    UniProtKB/TrEMBL
    B3KM65
    Conserved Domains (3) summary
    PRK11192
    Location:54491
    PRK11192; ATP-dependent RNA helicase SrmB; Provisional
    cd00079
    Location:278407
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:61267
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_007010.5NP_008941.3  probable ATP-dependent RNA helicase DDX52 isoform 1

    See identical proteins and their annotated locations for NP_008941.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC243585, AK001245, AK025721, BC041785
    Consensus CDS
    CCDS11323.1
    UniProtKB/Swiss-Prot
    Q9Y2R4
    UniProtKB/TrEMBL
    B3KM65
    Related
    ENSP00000479504.1, ENST00000617633.5
    Conserved Domains (1) summary
    COG0513
    Location:136599
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    37609739..37643448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524232.2XP_011522534.1  probable ATP-dependent RNA helicase DDX52 isoform X1

    Conserved Domains (3) summary
    smart00487
    Location:180389
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:386515
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:169375
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_011524233.3XP_011522535.1  probable ATP-dependent RNA helicase DDX52 isoform X2

    Conserved Domains (3) summary
    COG0513
    Location:10293
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00079
    Location:146275
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:6135
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    1848852..1882540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152300.2: Suppressed sequence

    Description
    NM_152300.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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