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Amhr2 anti-Mullerian hormone type 2 receptor [ Mus musculus (house mouse) ]

Gene ID: 110542, updated on 14-May-2024

Summary

Official Symbol
Amhr2provided by MGI
Official Full Name
anti-Mullerian hormone type 2 receptorprovided by MGI
Primary source
MGI:MGI:105062
See related
Ensembl:ENSMUSG00000023047 AllianceGenome:MGI:105062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C14; Mrii; Misiir; Misrii
Summary
Enables anti-Mullerian hormone receptor activity. Acts upstream of or within anti-Mullerian hormone signaling pathway; negative regulation of anti-Mullerian hormone signaling pathway; and sex differentiation. Predicted to be integral component of plasma membrane. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including early embryo; forebrain; genitourinary system; and nose. Used to study persistent Mullerian duct syndrome. Human ortholog(s) of this gene implicated in persistent Mullerian duct syndrome. Orthologous to human AMHR2 (anti-Mullerian hormone receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 55.6) and ovary adult (RPKM 49.5) See more
Orthologs
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Genomic context

See Amhr2 in Genome Data Viewer
Location:
15 F3; 15 57.58 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (102353437..102363075)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102445002..102454640)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Sp7 transcription factor 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:102212079-102212188 Neighboring gene STARR-seq mESC enhancer starr_39837 Neighboring gene STARR-seq mESC enhancer starr_39838 Neighboring gene STARR-seq mESC enhancer starr_39839 Neighboring gene STARR-seq mESC enhancer starr_39841 Neighboring gene trans-acting transcription factor 1 Neighboring gene STARR-seq mESC enhancer starr_39842 Neighboring gene STARR-positive B cell enhancer ABC_E7423 Neighboring gene STARR-positive B cell enhancer ABC_E1179 Neighboring gene STARR-seq mESC enhancer starr_39843 Neighboring gene predicted gene, 24128 Neighboring gene proline rich 13

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC141312

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables anti-Mullerian hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transforming growth factor beta receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transforming growth factor beta receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables transforming growth factor beta receptor activity, type II ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
anti-Muellerian hormone type-2 receptor
Names
AMH type II receptor
MIS type II receptor
anti-Muellerian hormone type II receptor
anti-Mullerian hormone type 2 receptor delta 2
anti-Mullerian hormone type 2 receptor delta 9/10
NP_001343504.1
NP_653130.2
XP_006520357.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356575.1NP_001343504.1  anti-Muellerian hormone type-2 receptor precursor

    Status: VALIDATED

    Source sequence(s)
    AC137156
    Consensus CDS
    CCDS27882.1
    UniProtKB/Swiss-Prot
    Q0VDQ4, Q8K592
    Conserved Domains (2) summary
    pfam01064
    Location:61119
    Activin_recp; Activin types I and II receptor domain
    cl21453
    Location:203504
    PKc_like; Protein Kinases, catalytic domain
  2. NM_144547.2NP_653130.2  anti-Muellerian hormone type-2 receptor precursor

    See identical proteins and their annotated locations for NP_653130.2

    Status: VALIDATED

    Source sequence(s)
    BB052908, BB868995, BC119571, CJ194934
    Consensus CDS
    CCDS27882.1
    UniProtKB/Swiss-Prot
    Q0VDQ4, Q8K592
    Related
    ENSMUSP00000023809.5, ENSMUST00000023809.11
    Conserved Domains (2) summary
    pfam01064
    Location:61119
    Activin_recp; Activin types I and II receptor domain
    cl21453
    Location:203504
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    102353437..102363075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520294.5XP_006520357.1  anti-Muellerian hormone type-2 receptor isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:203409
    PKc_like; Protein Kinases, catalytic domain