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Acat1 acetyl-Coenzyme A acetyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 110446, updated on 7-Apr-2019

Summary

Official Symbol
Acat1provided by MGI
Official Full Name
acetyl-Coenzyme A acetyltransferase 1provided by MGI
Primary source
MGI:MGI:87870
See related
Ensembl:ENSMUSG00000032047
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acat; 6330585C21Rik
Expression
Broad expression in liver E18 (RPKM 193.6), heart adult (RPKM 69.0) and 20 other tissues See more
Orthologs

Genomic context

See Acat1 in Genome Data Viewer
Location:
9 A5.3; 9 29.12 cM
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (53580522..53610350, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (53388627..53418455, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene ataxia telangiectasia mutated Neighboring gene nuclear protein in the AT region Neighboring gene cullin 5 Neighboring gene predicted gene 16124 Neighboring gene ribosomal protein S6, pseudogene 3 Neighboring gene RAB39, member RAS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
C-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
acetyl-CoA C-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acetyl-CoA C-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
acetyl-CoA C-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
acetyl-CoA C-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
coenzyme binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acetyl-CoA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acetyl-CoA catabolic process ISO
Inferred from Sequence Orthology
more info
 
coenzyme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
coenzyme A metabolic process ISO
Inferred from Sequence Orthology
more info
 
fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
isoleucine catabolic process ISO
Inferred from Sequence Orthology
more info
 
ketone body catabolic process ISO
Inferred from Sequence Orthology
more info
 
propionyl-CoA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane HDA PubMed 
mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
acetyl-CoA acetyltransferase, mitochondrial
Names
acetoacetyl-CoA thiolase
NP_659033.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144784.3NP_659033.1  acetyl-CoA acetyltransferase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_659033.1

    Status: VALIDATED

    Source sequence(s)
    AC156640
    Consensus CDS
    CCDS23184.1
    UniProtKB/Swiss-Prot
    Q8QZT1
    Related
    ENSMUSP00000034547.5, ENSMUST00000034547.5
    Conserved Domains (2) summary
    PLN02644
    Location:38424
    PLN02644; acetyl-CoA C-acetyltransferase
    cd00751
    Location:40423
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    53580522..53610350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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