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B4GAT1 beta-1,4-glucuronyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 11041, updated on 8-Jul-2021

Summary

Official Symbol
B4GAT1provided by HGNC
Official Full Name
beta-1,4-glucuronyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:15685
See related
Ensembl:ENSG00000174684 MIM:605517
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
iGAT; iGNT; B3GNT1; B3GNT6; B3GN-T1; MDDGA13; BETA3GNTI
Summary
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It is essential for the synthesis of poly-N-acetyllactosamine, a determinant for the blood group i antigen. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 72.1), adrenal (RPKM 23.3) and 22 other tissues See more
Orthologs
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Genomic context

See B4GAT1 in Genome Data Viewer
Location:
11q13.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (66345374..66347629, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66112845..66115100, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Ras and Rab interactor 1 Neighboring gene BRMS1 transcriptional repressor and anoikis regulator Neighboring gene uncharacterized LOC102724064 Neighboring gene tRNA-Ser (anticodon GCT) 3-1 Neighboring gene solute carrier family 29 member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef The yeast two-hybrid screen identifies the HIV-1 Nef interacting human protein UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) in cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
beta-1,4-glucuronyltransferase 1
Names
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
beta-1,3-N-acetylglucosaminyltransferase bGnT-6
i-beta-1,3-N-acetylglucosaminyltransferase
poly-N-acetyllactosamine extension enzyme
NP_006867.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033202.1 RefSeqGene

    Range
    5062..7317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006876.3NP_006867.1  beta-1,4-glucuronyltransferase 1

    See identical proteins and their annotated locations for NP_006867.1

    Status: REVIEWED

    Source sequence(s)
    AF029893, DA169103
    Consensus CDS
    CCDS8136.1
    UniProtKB/Swiss-Prot
    O43505
    UniProtKB/TrEMBL
    A0A024R5F9
    Related
    ENSP00000309096.4, ENST00000311181.5
    Conserved Domains (1) summary
    pfam13896
    Location:94408
    Glyco_transf_49; Glycosyl-transferase for dystroglycan

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    66345374..66347629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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