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B4GAT1 beta-1,4-glucuronyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 11041, updated on 13-Feb-2019

Summary

Official Symbol
B4GAT1provided by HGNC
Official Full Name
beta-1,4-glucuronyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:15685
See related
Ensembl:ENSG00000174684 MIM:605517
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
iGAT; iGNT; B3GNT1; B3GNT6; B3GN-T1; MDDGA13; BETA3GNTI
Summary
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It is essential for the synthesis of poly-N-acetyllactosamine, a determinant for the blood group i antigen. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 72.1), adrenal (RPKM 23.3) and 22 other tissues See more
Orthologs

Genomic context

See B4GAT1 in Genome Data Viewer
Location:
11q13.2
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (66345372..66347690, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66112843..66115161, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Ras and Rab interactor 1 Neighboring gene BRMS1 transcriptional repressor and anoikis regulator Neighboring gene uncharacterized LOC102724064 Neighboring gene transfer RNA-Ser (GCT) 3-1 Neighboring gene solute carrier family 29 member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef The yeast two-hybrid screen identifies the HIV-1 Nef interacting human protein UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) in cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Glycosaminoglycan metabolism, organism-specific biosystem (from REACTOME)
    Glycosaminoglycan metabolism, organism-specific biosystemGlycosaminoglycans (GAGs) are long, unbranched polysaccharides containing a repeating disaccharide unit composed of a hexosamine (either N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc)...
  • Keratan sulfate biosynthesis, organism-specific biosystem (from REACTOME)
    Keratan sulfate biosynthesis, organism-specific biosystemKeratan sulfate (KSI) is the best characterised keratan sulfate. It is 10 times more abundant in cornea than cartilage. KSI is attached to an asparagine (Asn) residue on the core protein via an N-lin...
  • Keratan sulfate/keratin metabolism, organism-specific biosystem (from REACTOME)
    Keratan sulfate/keratin metabolism, organism-specific biosystemKeratan sulfate (KS) (a glycosaminoglycan, GAG) is a linear polysaccharide that consists of the repeating disaccharide unit GlcNAc-Gal (N-acetylglucosamine-galactose). KS can perform a structural fun...
  • Mannose type O-glycan biosynthesis, organism-specific biosystem (from KEGG)
    Mannose type O-glycan biosynthesis, organism-specific biosystemBiosynthesis of mammalian O-mannosyl glycans is initiated by the transfer of mannose from mannose-P-Dol to serine or threonine residue, followed by extensions with N-acetylglucosamine (GlcNAc) and ga...
  • Mannose type O-glycan biosynthesis, conserved biosystem (from KEGG)
    Mannose type O-glycan biosynthesis, conserved biosystemBiosynthesis of mammalian O-mannosyl glycans is initiated by the transfer of mannose from mannose-P-Dol to serine or threonine residue, followed by extensions with N-acetylglucosamine (GlcNAc) and ga...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
    Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • O-linked glycosylation, organism-specific biosystem (from REACTOME)
    O-linked glycosylation, organism-specific biosystemO-glycosylation is an important post-translational modification (PTM) required for correct functioning of many proteins (Van den Steen et al. 1998, Moremen et al. 2012). The O-glycosylation of protei...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • terminal O-glycans residues modification, organism-specific biosystem (from BIOCYC)
    terminal O-glycans residues modification, organism-specific biosystemEnzymatic glycosylation of proteins and lipids is an abundant and important biological process. A great diversity of oligosaccharide structures and types of glycoconjugates is found in nature, and th...
  • terminal O-glycans residues modification, conserved biosystem (from BIOCYC)
    terminal O-glycans residues modification, conserved biosystemEnzymatic glycosylation of proteins and lipids is an abundant and important biological process. A great diversity of oligosaccharide structures and types of glycoconjugates is found in nature, and th...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
axon guidance IEA
Inferred from Electronic Annotation
more info
 
keratan sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
NOT poly-N-acetyllactosamine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
protein O-linked glycosylation TAS
Traceable Author Statement
more info
 
protein O-linked mannosylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
integral component of Golgi membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
beta-1,4-glucuronyltransferase 1
Names
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
beta-1,3-N-acetylglucosaminyltransferase bGnT-6
i-beta-1,3-N-acetylglucosaminyltransferase
poly-N-acetyllactosamine extension enzyme
NP_006867.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033202.1 RefSeqGene

    Range
    5001..7319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006876.3NP_006867.1  beta-1,4-glucuronyltransferase 1

    See identical proteins and their annotated locations for NP_006867.1

    Status: REVIEWED

    Source sequence(s)
    AF029893, DA169103
    Consensus CDS
    CCDS8136.1
    UniProtKB/Swiss-Prot
    O43505
    UniProtKB/TrEMBL
    A0A024R5F9
    Related
    ENSP00000309096.4, ENST00000311181.4
    Conserved Domains (1) summary
    pfam13896
    Location:94408
    Glyco_transf_49; Glycosyl-transferase for dystroglycan

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    66345372..66347690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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