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Qdpr quinoid dihydropteridine reductase [ Mus musculus (house mouse) ]

Gene ID: 110391, updated on 1-Mar-2024

Summary

Official Symbol
Qdprprovided by MGI
Official Full Name
quinoid dihydropteridine reductaseprovided by MGI
Primary source
MGI:MGI:97836
See related
Ensembl:ENSMUSG00000015806 AllianceGenome:MGI:97836
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dhpr; PKU2; D5Ertd371e; 2610008L04Rik
Summary
Predicted to enable 6,7-dihydropteridine reductase activity; identical protein binding activity; and nucleotide binding activity. Predicted to be involved in L-phenylalanine catabolic process and tetrahydrobiopterin biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Human ortholog(s) of this gene implicated in phenylketonuria. Orthologous to human QDPR (quinoid dihydropteridine reductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 202.3), cerebellum adult (RPKM 120.9) and 27 other tissues See more
Orthologs
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Genomic context

See Qdpr in Genome Data Viewer
Location:
5 B3; 5 24.9 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (45591374..45607571, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (45434032..45450229, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930431F12 gene Neighboring gene DNA segment, Chr 5, ERATO Doi 615, expressed Neighboring gene predicted gene, 46912 Neighboring gene STARR-seq mESC enhancer starr_12993 Neighboring gene STARR-seq mESC enhancer starr_12994 Neighboring gene STARR-seq mESC enhancer starr_12995 Neighboring gene STARR-seq mESC enhancer starr_12996 Neighboring gene STARR-positive B cell enhancer ABC_E669 Neighboring gene STARR-positive B cell enhancer ABC_E6329 Neighboring gene STARR-seq mESC enhancer starr_12997 Neighboring gene clarin 2 Neighboring gene leucine aminopeptidase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 6,7-dihydropteridine reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 6,7-dihydropteridine reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables NADH binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NADH binding ISO
Inferred from Sequence Orthology
more info
 
enables NADPH binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NADPH binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in L-phenylalanine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tetrahydrobiopterin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tetrahydrobiopterin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
dihydropteridine reductase
Names
HDHPR
NP_077198.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024236.2NP_077198.1  dihydropteridine reductase

    See identical proteins and their annotated locations for NP_077198.1

    Status: VALIDATED

    Source sequence(s)
    AC092711, AK166694
    Consensus CDS
    CCDS19272.1
    UniProtKB/Swiss-Prot
    Q3TT09, Q8BVI4, Q9D0K4
    UniProtKB/TrEMBL
    A0A0G2JGJ1
    Related
    ENSMUSP00000015950.6, ENSMUST00000015950.12
    Conserved Domains (1) summary
    cd05334
    Location:7229
    DHPR_SDR_c_like; dihydropteridine reductase (DHPR), classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    45591374..45607571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)