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Shroom2 shroom family member 2 [ Mus musculus (house mouse) ]

Gene ID: 110380, updated on 8-Feb-2024

Summary

Official Symbol
Shroom2provided by MGI
Official Full Name
shroom family member 2provided by MGI
Primary source
MGI:MGI:107194
See related
Ensembl:ENSMUSG00000045180 AllianceGenome:MGI:107194
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Apxl; Shrm2; 4832440C16; C630003H05Rik
Summary
Enables actin filament binding activity; beta-catenin binding activity; and protein domain specific binding activity. Involved in cell migration and melanosome organization. Acts upstream of or within cell-cell junction maintenance and negative regulation of actin filament depolymerization. Located in several cellular components, including adherens junction; apical plasma membrane; and bicellular tight junction. Colocalizes with cortical actin cytoskeleton. Is expressed in several structures, including blood vessel; central nervous system; epithelium; inner ear; and retina inner plexiform layer. Orthologous to human SHROOM2 (shroom family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 10.6), frontal lobe adult (RPKM 7.9) and 22 other tissues See more
Orthologs
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Genomic context

See Shroom2 in Genome Data Viewer
Location:
X F3; X 68.46 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (151392505..151553784, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (152609509..152770788, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_48098 Neighboring gene claudin 34A Neighboring gene STARR-seq mESC enhancer starr_48099 Neighboring gene cell division protein kinase 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48100 Neighboring gene RAB7, member RAS oncogene family pseudogene Neighboring gene STARR-seq mESC enhancer starr_48101 Neighboring gene STARR-seq mESC enhancer starr_48103 Neighboring gene STARR-seq mESC enhancer starr_48104 Neighboring gene phosphoglycerate mutase 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48107 Neighboring gene G protein-coupled receptor 143 Neighboring gene ribosomal protein L7A, pseudogene 12 Neighboring gene ribosomal protein S7, pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
NOT involved_in actin filament bundle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in apical protein localization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in brain development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in camera-type eye development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in camera-type eye morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in cell morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell-cell junction maintenance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular pigment accumulation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in ear development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in establishment of melanosome localization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in eye pigment granule organization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in lens morphogenesis in camera-type eye ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in melanosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of actin filament depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in apical junction complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in apical junction complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290684.1NP_001277613.1  protein Shroom2 isoform 2

    See identical proteins and their annotated locations for NP_001277613.1

    Status: VALIDATED

    Source sequence(s)
    AL805960, AL807777
    Consensus CDS
    CCDS72455.1
    UniProtKB/Swiss-Prot
    A2ALU4, Q2EY23, Q8C7N1, Q8CCR2, Q8CDZ0
    Related
    ENSMUSP00000057500.5, ENSMUST00000062317.5
    Conserved Domains (3) summary
    cd00992
    Location:24105
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam08687
    Location:11861474
    ASD2; Apx/Shroom domain ASD2
    pfam08688
    Location:662836
    ASD1; Apx/Shroom domain ASD1
  2. NM_001290685.1NP_001277614.1  protein Shroom2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AK049833, AK049850, AL805960, BC092373, BY125315
    UniProtKB/Swiss-Prot
    A2ALU4
    UniProtKB/TrEMBL
    Q8C7N5
    Related
    ENSMUST00000137217.8
    Conserved Domains (1) summary
    pfam08687
    Location:166455
    ASD2; Apx/Shroom domain ASD2
  3. NM_001290686.1NP_001277615.1  protein Shroom2 isoform 4

    See identical proteins and their annotated locations for NP_001277615.1

    Status: VALIDATED

    Source sequence(s)
    AK029338, AK049833, BY125315
    UniProtKB/Swiss-Prot
    A2ALU4
    UniProtKB/TrEMBL
    Q8C7N5
    Conserved Domains (1) summary
    pfam08687
    Location:151439
    ASD2; Apx/Shroom domain ASD2
  4. NM_001290687.2NP_001277616.1  protein Shroom2 isoform 4

    See identical proteins and their annotated locations for NP_001277616.1

    Status: VALIDATED

    Source sequence(s)
    AK049833, AK049850, AL805960, CF534250, CO431718
    UniProtKB/Swiss-Prot
    A2ALU4
    UniProtKB/TrEMBL
    Q8C7N5
    Conserved Domains (1) summary
    pfam08687
    Location:151439
    ASD2; Apx/Shroom domain ASD2
  5. NM_001359158.1NP_001346087.1  protein Shroom2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL805960
    Conserved Domains (1) summary
    pfam08687
    Location:151439
    ASD2; Apx/Shroom domain ASD2
  6. NM_001359161.1NP_001346090.1  protein Shroom2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL805960
    Conserved Domains (1) summary
    pfam08687
    Location:151439
    ASD2; Apx/Shroom domain ASD2
  7. NM_001359163.1NP_001346092.1  protein Shroom2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL805960
    Conserved Domains (1) summary
    pfam08687
    Location:151439
    ASD2; Apx/Shroom domain ASD2
  8. NM_172441.3NP_766029.2  protein Shroom2 isoform 1

    See identical proteins and their annotated locations for NP_766029.2

    Status: VALIDATED

    Source sequence(s)
    AK049833, AK049850, AL805960, AL807777, BF463332, CK635066
    Consensus CDS
    CCDS41179.1
    UniProtKB/TrEMBL
    A7TU71
    Related
    ENSMUSP00000098701.3, ENSMUST00000101141.9
    Conserved Domains (3) summary
    cd00992
    Location:24105
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam08687
    Location:11921480
    ASD2; Apx/Shroom domain ASD2
    pfam08688
    Location:662836
    ASD1; Apx/Shroom domain ASD1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    151392505..151553784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528683.4XP_006528746.1  protein Shroom2 isoform X1

    Conserved Domains (3) summary
    cd00992
    Location:24105
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam08687
    Location:11871475
    ASD2; Apx/Shroom domain ASD2
    pfam08688
    Location:662836
    ASD1; Apx/Shroom domain ASD1
  2. XM_011247774.4XP_011246076.1  protein Shroom2 isoform X2

    See identical proteins and their annotated locations for XP_011246076.1

    UniProtKB/Swiss-Prot
    A2ALU4
    Conserved Domains (1) summary
    pfam08687
    Location:151439
    ASD2; Apx/Shroom domain ASD2
  3. XM_011247775.4XP_011246077.1  protein Shroom2 isoform X2

    See identical proteins and their annotated locations for XP_011246077.1

    UniProtKB/Swiss-Prot
    A2ALU4
    Conserved Domains (1) summary
    pfam08687
    Location:151439
    ASD2; Apx/Shroom domain ASD2
  4. XM_011247777.4XP_011246079.1  protein Shroom2 isoform X2

    See identical proteins and their annotated locations for XP_011246079.1

    UniProtKB/Swiss-Prot
    A2ALU4
    Conserved Domains (1) summary
    pfam08687
    Location:151439
    ASD2; Apx/Shroom domain ASD2