RIPK3 receptor interacting serine/threonine kinase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RIPK3provided by HGNC
Official Full Name: receptor interacting serine/threonine kinase 3provided by HGNC
Primary source: HGNC:HGNC:10021
See related: Ensembl:ENSG00000129465 MIM:605817; AllianceGenome:HGNC:10021
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RIP3
Summary: The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]
Expression: Broad expression in small intestine (RPKM 12.2), duodenum (RPKM 10.4) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (24336025..24339991, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (18534370..18538336, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (24805231..24809197, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bladder-cancer-derived exosomal circRNA_0013936 promotes suppressive immunity by up-regulating fatty acid transporter protein 2 and down-regulating receptor-interacting protein kinase 3 in PMN-MDSCs.
Title: Bladder-cancer-derived exosomal circRNA_0013936 promotes suppressive immunity by up-regulating fatty acid transporter protein 2 and down-regulating receptor-interacting protein kinase 3 in PMN-MDSCs.
RIP3 in Necroptosis: Underlying Contributions to Traumatic Brain Injury.
Title: RIP3 in Necroptosis: Underlying Contributions to Traumatic Brain Injury.
Neutrophil extracellular traps aggravate intestinal epithelial necroptosis in ischaemia-reperfusion by regulating TLR4/RIPK3/FUNDC1-required mitophagy.
Title: Neutrophil extracellular traps aggravate intestinal epithelial necroptosis in ischaemia-reperfusion by regulating TLR4/RIPK3/FUNDC1-required mitophagy.
Dichotomous roles of RIPK3 in regulating the IFN response and NLRP3 inflammasome in human monocytes.
Title: Dichotomous roles of RIPK3 in regulating the IFN response and NLRP3 inflammasome in human monocytes.
Inhibition of Urban Particulate Matter-Induced Airway Inflammation by RIPK3 through the Regulation of Tight Junction Protein Production.
Title: Inhibition of Urban Particulate Matter-Induced Airway Inflammation by RIPK3 through the Regulation of Tight Junction Protein Production.
PRMT1 reverts the immune escape of necroptotic colon cancer through RIP3 methylation.
Title: PRMT1 reverts the immune escape of necroptotic colon cancer through RIP3 methylation.
Upregulation of necroptosis markers RIPK3/MLKL and their crosstalk with autophagy-related protein Beclin-1 in primary immune thrombocytopenia.
Title: Upregulation of necroptosis markers RIPK3/MLKL and their crosstalk with autophagy-related protein Beclin-1 in primary immune thrombocytopenia.
RIPK3 promoter hypermethylation in hepatocytes protects from bile acid-induced inflammation and necroptosis.
Title: RIPK3 promoter hypermethylation in hepatocytes protects from bile acid-induced inflammation and necroptosis.
Encephalitis and poor neuronal death-mediated control of herpes simplex virus in human inherited RIPK3 deficiency.
Title: Encephalitis and poor neuronal death-mediated control of herpes simplex virus in human inherited RIPK3 deficiency.
[Inhibition of receptor-interacting protein 3 improves experimental autoimmune hepatitis].
Title: [Inhibition of receptor-interacting protein 3 improves experimental autoimmune hepatitis].

Submit: New GeneRIF Correction See all GeneRIFs (151)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables protein-containing complex binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coactivator activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell differentiation in thymus	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in activation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amyloid fibril formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to hydrogen peroxide	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in execution phase of necroptosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lymph node development	ISS Inferred from Sequence or Structural Similarity more info
involved_in necroptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in necroptotic process	TAS Traceable Author Statement more info
involved_in necroptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in necroptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of necroptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of necroptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in programmed necrotic cell death	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein modification process	TAS Traceable Author Statement more info	PubMed
involved_in reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of T cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of activated T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of activation-induced cell death of T cells	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of adaptive immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in spleen development	ISS Inferred from Sequence or Structural Similarity more info
involved_in thymus development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: receptor-interacting serine/threonine-protein kinase 3

Names: RIP-3; RIP-like protein kinase 3; receptor interacting protein 3

NP_006862.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_046975.1 RefSeqGene

Range

5046..9012

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_006871.4 → NP_006862.2 receptor-interacting serine/threonine-protein kinase 3

See identical proteins and their annotated locations for NP_006862.2

Status: REVIEWED

Source sequence(s)

BC062584, BE676675, DB274842

Consensus CDS

CCDS9628.1

UniProtKB/Swiss-Prot

B4DJL9, C4AM87, Q5J795, Q5J796, Q6P5Y1, Q9Y572

Related

ENSP00000216274.5, ENST00000216274.10

Conserved Domains (3) summary

smart00220
Location:22 → 280

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam12721
Location:419 → 468

RHIM; RIP homotypic interaction motif

cl21453
Location:27 → 280

PKc_like; Protein Kinases, catalytic domain