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Dync2h1 dynein cytoplasmic 2 heavy chain 1 [ Mus musculus (house mouse) ]

Gene ID: 110350, updated on 10-Oct-2019

Summary

Official Symbol
Dync2h1provided by MGI
Official Full Name
dynein cytoplasmic 2 heavy chain 1provided by MGI
Primary source
MGI:MGI:107736
See related
Ensembl:ENSMUSG00000047193
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DHC2; DHC11; DHC1b; Dnchc2; mDHC11; m152Asp; m407Asp; AI448217; b2b414Clo; 4432416O06Rik; D030010H02Rik; D330044F14Rik
Expression
Broad expression in testis adult (RPKM 4.9), CNS E11.5 (RPKM 2.2) and 18 other tissues See more
Orthologs

Genomic context

See Dync2h1 in Genome Data Viewer
Location:
9 A1; 9
Exon count:
93
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (6928550..7178306, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (6928503..7177046, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 21089 Neighboring gene U6 spliceosomal RNA Neighboring gene DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae) Neighboring gene predicted gene, 31639 Neighboring gene matrix metallopeptidase 13

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Gene trapped (1)  1 citation
  • Chemically induced (ENU) (6)  1 citation
  • Endonuclease-mediated (1) 

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • KIAA1997

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent microtubule motor activity, minus-end-directed IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to ATP-dependent microtubule motor activity, minus-end-directed ISO
Inferred from Sequence Orthology
more info
 
dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein light intermediate chain binding ISO
Inferred from Sequence Orthology
more info
 
microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
motor activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Golgi organization ISO
Inferred from Sequence Orthology
more info
 
cell projection organization IEA
Inferred from Electronic Annotation
more info
 
cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
intraciliary retrograde transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intraciliary retrograde transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to cilium IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
spinal cord motor neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
axoneme IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axoneme IDA
Inferred from Direct Assay
more info
PubMed 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cilium IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic dynein complex ISM
Inferred from Sequence Model
more info
PubMed 
cytoplasmic dynein complex ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
microtubule ISO
Inferred from Sequence Orthology
more info
 
motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytoplasmic dynein 2 heavy chain 1
Names
cytoplasmic dynein heavy chain 2
dynein heavy chain 11
dynein heavy chain isotype 1B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364519.1NP_001351448.1  cytoplasmic dynein 2 heavy chain 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC155908, BC088991, DQ104402
    Related
    ENSMUSP00000120322.1, ENSMUST00000139115.1
    Conserved Domains (1) summary
    pfam08385
    Location:161639
    DHC_N1; Dynein heavy chain, N-terminal region 1
  2. NM_029851.3NP_084127.2  cytoplasmic dynein 2 heavy chain 1 isoform 1

    See identical proteins and their annotated locations for NP_084127.2

    Status: VALIDATED

    Source sequence(s)
    AC155908, DQ104402
    Consensus CDS
    CCDS40528.1
    UniProtKB/Swiss-Prot
    Q45VK7
    Related
    ENSMUSP00000046733.6, ENSMUST00000048417.12
    Conserved Domains (7) summary
    pfam03028
    Location:36144295
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam07728
    Location:19742110
    AAA_5; AAA domain (dynein-related subfamily)
    pfam08385
    Location:161639
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:11201519
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:28963228
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:32523466
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:16511881
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p6 C57BL/6J

    Range
    6928550..7178306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509827.4XP_006509890.1  cytoplasmic dynein 2 heavy chain 1 isoform X3

    Conserved Domains (7) summary
    pfam03028
    Location:36144295
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam07728
    Location:19742110
    AAA_5; AAA domain (dynein-related subfamily)
    pfam08385
    Location:161639
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:11201519
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:28893221
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:32453466
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:16511881
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_030244008.1XP_030099868.1  cytoplasmic dynein 2 heavy chain 1 isoform X1

  3. XM_030244009.1XP_030099869.1  cytoplasmic dynein 2 heavy chain 1 isoform X2

  4. XM_006509826.4XP_006509889.1  cytoplasmic dynein 2 heavy chain 1 isoform X1

    UniProtKB/Swiss-Prot
    Q45VK7
    Related
    ENSMUSP00000116679.1, ENSMUST00000147193.7
    Conserved Domains (7) summary
    pfam03028
    Location:36214302
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam07728
    Location:19742110
    AAA_5; AAA domain (dynein-related subfamily)
    pfam08385
    Location:161639
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:11201519
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:28963228
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:32523473
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:16511881
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_017313101.1XP_017168590.1  cytoplasmic dynein 2 heavy chain 1 isoform X4

  6. XM_030244010.1XP_030099870.1  cytoplasmic dynein 2 heavy chain 1 isoform X5

RNA

  1. XR_003947762.1 RNA Sequence

  2. XR_001778791.2 RNA Sequence

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