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RIPK3 receptor interacting serine/threonine kinase 3 [ Homo sapiens (human) ]

Gene ID: 11035, updated on 13-Jan-2020

Summary

Official Symbol
RIPK3provided by HGNC
Official Full Name
receptor interacting serine/threonine kinase 3provided by HGNC
Primary source
HGNC:HGNC:10021
See related
Ensembl:ENSG00000129465 MIM:605817
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIP3
Summary
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]
Expression
Broad expression in small intestine (RPKM 12.2), duodenum (RPKM 10.4) and 21 other tissues See more
Orthologs

Genomic context

See RIPK3 in Genome Data Viewer
Location:
14q12
Exon count:
10
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (24336025..24339991, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24805227..24809242, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene leukotriene B4 receptor 2 Neighboring gene leukotriene B4 receptor Neighboring gene adenylate cyclase 4 Neighboring gene nuclear factor of activated T cells 4 Neighboring gene NYN domain and retroviral integrase containing

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ADCY4

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NF-kappaB-inducing kinase activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
protein-containing complex binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
NIK/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
T cell differentiation in thymus ISS
Inferred from Sequence or Structural Similarity
more info
 
T cell homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
amyloid fibril formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
cellular response to hydrogen peroxide ISS
Inferred from Sequence or Structural Similarity
more info
 
lymph node development ISS
Inferred from Sequence or Structural Similarity
more info
 
necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
necroptotic process TAS
Traceable Author Statement
more info
 
positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ligase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of necroptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
positive regulation of oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
programmed necrotic cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein heterooligomerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of T cell mediated cytotoxicity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of activated T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of activation-induced cell death of T cells ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of adaptive immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of interferon-gamma production ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
spleen development ISS
Inferred from Sequence or Structural Similarity
more info
 
thymus development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
receptor-interacting serine/threonine-protein kinase 3
Names
RIP-3
RIP-like protein kinase 3
receptor interacting protein 3
NP_006862.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046975.1 RefSeqGene

    Range
    5046..9012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006871.4NP_006862.2  receptor-interacting serine/threonine-protein kinase 3

    See identical proteins and their annotated locations for NP_006862.2

    Status: REVIEWED

    Source sequence(s)
    BC062584, BE676675, DB274842
    Consensus CDS
    CCDS9628.1
    UniProtKB/Swiss-Prot
    Q9Y572
    Related
    ENSP00000216274.5, ENST00000216274.10
    Conserved Domains (3) summary
    smart00220
    Location:22280
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12721
    Location:419468
    RHIM; RIP homotypic interaction motif
    cl21453
    Location:27280
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    24336025..24339991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p13 PATCHES

    Range
    637003..640969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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