Cox6b1 cytochrome c oxidase, subunit 6B1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cox6b1provided by MGI
Official Full Name: cytochrome c oxidase, subunit 6B1provided by MGI
Primary source: MGI:MGI:107460
See related: Ensembl:ENSMUSG00000036751 AllianceGenome:MGI:107460
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cox6b; COX VIb-1; 2010000G05Rik
Summary: Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; heart; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX6B1 (cytochrome c oxidase subunit 6B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in heart adult (RPKM 546.5), kidney adult (RPKM 430.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 18.84 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (30316396..30325539, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30616971..30626114, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

gene expression of the Cox subunits, Cox5a, 5b, and 6b1 is not required for embryo developmental events up to the blastocyst stage
Title: Gene expression of cox5a, 5b, or 6b1 and their roles in preimplantation mouse embryos.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cox6b1 (e-PCR), detects polymorphism
- UniSTS:531501

Homology

Homologs of the Cox6b1 gene: The Cox6b1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog.
Orthologs from Annotation Pipeline: 418 organisms have orthologs with human gene Cox6b1
Orthologs

Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	HDA more info	PubMed
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of mitochondrial respiratory chain complex IV	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex IV	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: cytochrome c oxidase subunit 6B1

Names: cytochrome c oxidase, subunit VIb polypeptide 1

NP_079904.1

EC 7.1.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025628.3 → NP_079904.1 cytochrome c oxidase subunit 6B1

See identical proteins and their annotated locations for NP_079904.1

Status: VALIDATED

Source sequence(s)

AK007996, AW047421

Consensus CDS

CCDS39887.1

UniProtKB/Swiss-Prot

P56391, Q545A3

UniProtKB/TrEMBL

A0A6P5Q1F7, A0A8C6GKW0

Related

ENSMUSP00000075150.5, ENSMUST00000075738.6

Conserved Domains (1) summary

cd00926
Location:8 → 85

Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...