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Glra3 glycine receptor, alpha 3 subunit [ Mus musculus (house mouse) ]

Gene ID: 110304, updated on 9-Mar-2023

Summary

Official Symbol
Glra3provided by MGI
Official Full Name
glycine receptor, alpha 3 subunitprovided by MGI
Primary source
MGI:MGI:95749
See related
Ensembl:ENSMUSG00000038257 AllianceGenome:MGI:95749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable glycine-gated chloride ion channel activity. Predicted to contribute to extracellularly glycine-gated chloride channel activity and glycine binding activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within glutamate receptor clustering. Located in GABA-ergic synapse and glutamatergic synapse. Is active in glycinergic synapse. Is expressed in central nervous system and eye. Orthologous to human GLRA3 (glycine receptor alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Glra3 in Genome Data Viewer
Location:
8 B2; 8 29.69 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (56393453..56583105)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (55940418..56130070)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene methyltransferase like 13 pseudogene Neighboring gene a disintegrin and metallopeptidase domain 29 Neighboring gene ribosomal protein S7 pseudogene Neighboring gene hydroxyprostaglandin dehydrogenase 15 (NAD) Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables extracellularly glycine-gated chloride channel activity ISO
Inferred from Sequence Orthology
more info
 
enables glycine binding IEA
Inferred from Electronic Annotation
more info
 
enables glycine-gated chloride ion channel activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmitter-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to zinc ion ISO
Inferred from Sequence Orthology
more info
 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chloride transport IEA
Inferred from Electronic Annotation
more info
 
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to amino acid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
part_of glycine-gated chloride channel complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in glycinergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glycinergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glycinergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glycine receptor subunit alpha-3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368774.2NP_001355703.1  glycine receptor subunit alpha-3 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC117729, AC119900
    Conserved Domains (1) summary
    TIGR00860
    Location:12436
    LIC; Cation transporter family protein
  2. NM_080438.4NP_536686.3  glycine receptor subunit alpha-3 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC117729, AC119900
    Consensus CDS
    CCDS40340.1
    UniProtKB/Swiss-Prot
    Q7TSQ2
    Related
    ENSMUSP00000000275.9, ENSMUST00000000275.10
    Conserved Domains (1) summary
    TIGR00860
    Location:12451
    LIC; Cation transporter family protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    56393453..56583105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)