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LILRA2 leukocyte immunoglobulin like receptor A2 [ Homo sapiens (human) ]

Gene ID: 11027, updated on 1-Jun-2020

Summary

Official Symbol
LILRA2provided by HGNC
Official Full Name
leukocyte immunoglobulin like receptor A2provided by HGNC
Primary source
HGNC:HGNC:6603
See related
Ensembl:ENSG00000239998 MIM:604812
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ILT1; LIR7; CD85H; LIR-7
Summary
This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. [provided by RefSeq, Mar 2014]
Expression
Biased expression in bone marrow (RPKM 15.6), spleen (RPKM 8.6) and 5 other tissues See more
Orthologs

Genomic context

See LILRA2 in Genome Data Viewer
Location:
19q13.42
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (54572988..54590287)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55084469..55099027)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, three Ig domains X1 (pseudogene) Neighboring gene uncharacterized LOC107985347 Neighboring gene uncharacterized LOC105372461 Neighboring gene leukocyte immunoglobulin like receptor A1 Neighboring gene leukocyte immunoglobulin like receptor B1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
IgM binding IDA
Inferred from Direct Assay
more info
PubMed 
antigen binding TAS
Traceable Author Statement
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
defense response TAS
Traceable Author Statement
more info
PubMed 
granulocyte colony-stimulating factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
granulocyte macrophage colony-stimulating factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
innate immune response activating cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-8 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of toll-like receptor 4 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil activation involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell activation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-1 beta secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor secretion IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
leukocyte immunoglobulin-like receptor subfamily A member 2
Names
CD85 antigen-like family member H
immunoglobulin-like transcript 1
leucocyte Ig-like receptor A2
leukocyte immunoglobulin-like receptor 7
leukocyte immunoglobulin-like receptor subfamily A member 2 soluble
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034038.1 RefSeqGene

    Range
    5001..19564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130917.3NP_001124389.2  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform a precursor

    See identical proteins and their annotated locations for NP_001124389.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AC245036, AK310088, CB046242, U82278
    Consensus CDS
    CCDS46179.1
    Related
    ENSP00000375618.3, ENST00000391738.8
    Conserved Domains (2) summary
    smart00410
    Location:35116
    IG_like; Immunoglobulin like
    cl11960
    Location:27117
    Ig; Immunoglobulin domain
  2. NM_001290270.1NP_001277199.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform c precursor

    See identical proteins and their annotated locations for NP_001277199.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks in-frame exons in the 5' and 3' coding regions, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC245036, AK310088, CB046242, U82276
    Consensus CDS
    CCDS74453.1
    UniProtKB/TrEMBL
    A8MZH0
    Related
    ENSP00000375617.1, ENST00000391737.3
    Conserved Domains (2) summary
    smart00410
    Location:23104
    IG_like; Immunoglobulin like
    cl11960
    Location:15105
    Ig; Immunoglobulin domain
  3. NM_001290271.2NP_001277200.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform d precursor

    See identical proteins and their annotated locations for NP_001277200.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, and lacks an exon and contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is longer than isoform a.
    Source sequence(s)
    AC245036, AK310088, CB046242, DA264697
    Conserved Domains (2) summary
    smart00410
    Location:35116
    IG_like; Immunoglobulin like
    cl11960
    Location:122217
    Ig; Immunoglobulin domain
  4. NM_006866.4NP_006857.2  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC245036, BC027916, CB046242, DA465773, DA931441
    Consensus CDS
    CCDS12900.1
    UniProtKB/Swiss-Prot
    Q8N149
    Related
    ENSP00000251376.3, ENST00000251376.7
    Conserved Domains (2) summary
    smart00410
    Location:35116
    IG_like; Immunoglobulin like
    cl11960
    Location:27117
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    54572988..54590287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722986.1XP_006723049.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X1

    See identical proteins and their annotated locations for XP_006723049.1

    Conserved Domains (2) summary
    smart00410
    Location:35116
    IG_like; Immunoglobulin like
    cl11960
    Location:122217
    Ig; Immunoglobulin domain
  2. XM_011526385.1XP_011524687.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X2

    See identical proteins and their annotated locations for XP_011524687.1

    Related
    ENSP00000251377.3, ENST00000251377.7
    Conserved Domains (2) summary
    smart00410
    Location:35116
    IG_like; Immunoglobulin like
    cl11960
    Location:27117
    Ig; Immunoglobulin domain
  3. XM_017026224.1XP_016881713.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X6

  4. XM_011526386.1XP_011524688.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X3

    Conserved Domains (2) summary
    smart00410
    Location:23104
    IG_like; Immunoglobulin like
    cl11960
    Location:110205
    Ig; Immunoglobulin domain
  5. XM_011526387.1XP_011524689.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X4

    See identical proteins and their annotated locations for XP_011524689.1

    UniProtKB/TrEMBL
    A8MZH0
    Conserved Domains (2) summary
    smart00410
    Location:23104
    IG_like; Immunoglobulin like
    cl11960
    Location:15105
    Ig; Immunoglobulin domain
  6. XM_011526389.1XP_011524691.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X7

    Conserved Domains (2) summary
    smart00410
    Location:128189
    IG_like; Immunoglobulin like
    cl11960
    Location:16111
    Ig; Immunoglobulin domain
  7. XM_011526388.1XP_011524690.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X5

    Conserved Domains (2) summary
    smart00410
    Location:23104
    IG_like; Immunoglobulin like
    cl11960
    Location:15105
    Ig; Immunoglobulin domain
  8. XM_011526390.1XP_011524692.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X8

    Related
    ENSP00000388131.1, ENST00000439534.5
    Conserved Domains (2) summary
    smart00410
    Location:35116
    IG_like; Immunoglobulin like
    cl11960
    Location:122217
    Ig; Immunoglobulin domain
  9. XM_011526391.1XP_011524693.1  leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X9

    Conserved Domains (2) summary
    smart00410
    Location:35116
    IG_like; Immunoglobulin like
    cl11960
    Location:122217
    Ig; Immunoglobulin domain

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    479378..496677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    477872..495171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p13 ALT_REF_LOCI_9

    Range
    555569..572866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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