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LILRA3 leukocyte immunoglobulin like receptor A3 [ Homo sapiens (human) ]

Gene ID: 11026, updated on 23-Nov-2021

Summary

Official Symbol
LILRA3provided by HGNC
Official Full Name
leukocyte immunoglobulin like receptor A3provided by HGNC
Primary source
HGNC:HGNC:6604
See related
MIM:604818
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HM31; HM43; ILT6; LIR4; CD85E; ILT-6; LIR-4
Summary
This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. [provided by RefSeq, Mar 2014]
Annotation information
Annotation category: only annotated on alternate loci in reference assembly
Orthologs
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Genomic context

See LILRA3 in Genome Data Viewer
Location:
19q13.4
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 (ALT_REF_LOCI_9) NT_187693.1 (270964..275379, complement)
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 (ALT_REF_LOCI_1) NW_003571054.1 (270735..275150, complement)
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 (ALT_REF_LOCI_2) NW_003571055.2 (270616..275031, complement)
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 (ALT_REF_LOCI_8) NW_003571061.2 (270991..275406, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 (PATCHES) NW_003571054.1 (270735..275150, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 (PATCHES) NW_003571055.1 (270615..275030, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 (PATCHES) NW_003571061.1 (270990..275405, complement)

NW_003571054.1Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor B2 Neighboring gene microRNA 4752 Neighboring gene leukocyte immunoglobulin like receptor A5 Neighboring gene vomeronasal 1 receptor 104 pseudogene

NW_003571055.2Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin-like receptor subfamily B member 3 Neighboring gene microRNA 4752 Neighboring gene leukocyte immunoglobulin like receptor A5 Neighboring gene vomeronasal 1 receptor 104 pseudogene

NW_003571061.2Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor B2 Neighboring gene microRNA 4752 Neighboring gene leukocyte immunoglobulin like receptor A5 Neighboring gene vomeronasal 1 receptor 104 pseudogene

NT_187693.1Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor B2 Neighboring gene microRNA 4752 Neighboring gene leukocyte immunoglobulin like receptor A5 Neighboring gene vomeronasal 1 receptor 104 pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables inhibitory MHC class I receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in specific granule membrane TAS
Traceable Author Statement
more info
 
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
leukocyte immunoglobulin-like receptor subfamily A member 3
Names
CD85 antigen-like family member E
immunoglobulin-like transcript 6
leucocyte Ig-like receptor A3
leukocyte immunoglobulin-like receptor 4
leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
monocyte inhibitory receptor HM43/HM31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034046.1 RefSeqGene

    Range
    5001..9416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001172654.2NP_001166125.1  leukocyte immunoglobulin-like receptor subfamily A member 3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001166125.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AF014924, AI655471, BX280714
    UniProtKB/Swiss-Prot
    Q8N6C8
    Conserved Domains (3) summary
    cd05751
    Location:27119
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:271333
    IG_like; Immunoglobulin like
    cl11960
    Location:261355
    Ig; Immunoglobulin domain
  2. NM_006865.4NP_006856.3  leukocyte immunoglobulin-like receptor subfamily A member 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006856.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF014923, AF025527, AI655471
    UniProtKB/Swiss-Prot
    Q8N6C8
    Conserved Domains (3) summary
    cd05751
    Location:27119
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:335397
    IG_like; Immunoglobulin like
    cl11960
    Location:124219
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    270735..275150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NW_003571055.2 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    270616..275031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_8

Genomic

  1. NW_003571061.2 Reference GRCh38.p13 ALT_REF_LOCI_8

    Range
    270991..275406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p13 ALT_REF_LOCI_9

    Range
    270964..275379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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