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Triobp TRIO and F-actin binding protein [ Mus musculus (house mouse) ]

Gene ID: 110253, updated on 18-Apr-2024

Summary

Official Symbol
Triobpprovided by MGI
Official Full Name
TRIO and F-actin binding proteinprovided by MGI
Primary source
MGI:MGI:1349410
See related
Ensembl:ENSMUSG00000033088 AllianceGenome:MGI:1349410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tara; EST478828; mKIAA1662
Summary
This gene encodes a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility, and cell growth. The encoded protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in the human gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants have been described [provided by RefSeq, Sep 2012]
Expression
Ubiquitous expression in adrenal adult (RPKM 14.9), ovary adult (RPKM 12.4) and 28 other tissues See more
Orthologs
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Genomic context

Location:
15 E1; 15 37.7 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78831924..78890069)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78947724..79005869)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30368 Neighboring gene STARR-positive B cell enhancer ABC_E10867 Neighboring gene lectin, galactose binding, soluble 1 Neighboring gene nucleolar protein 12 Neighboring gene STARR-positive B cell enhancer ABC_E8975 Neighboring gene predicted gene 10865 Neighboring gene microRNA 6956 Neighboring gene predicted gene, 17753 Neighboring gene H1.0 linker histone

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (2) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in stereocilium base IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
TRIO and F-actin-binding protein
Names
protein Tara
trio-associated repeat on actin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024716.1NP_001019887.1  TRIO and F-actin-binding protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains a distinct 5' UTR and 5' coding region, which causes translation initiation to occur at a downstream start codon, compared to variant 3. The encoded protein (isoform 1) has a shorter N-terminus when compared to isoform 3.
    Source sequence(s)
    AK085512, BX528408, BY199415, BY761337
    Consensus CDS
    CCDS37138.1
    UniProtKB/TrEMBL
    A0A2U3TZ82
    Related
    ENSMUSP00000105309.3, ENSMUST00000109687.9
    Conserved Domains (3) summary
    cd13275
    Location:56157
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:56149
    PH; PH domain
    cl12013
    Location:380519
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. NM_001039155.1NP_001034244.1  TRIO and F-actin-binding protein isoform 4

    See identical proteins and their annotated locations for NP_001034244.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains a distinct 3' UTR and lacks a portion of the 3' coding region, compared to variant 3. The resulting isoform (4) has a shorter C-terminus when compared to isoform 3.
    Source sequence(s)
    DQ228002
    Consensus CDS
    CCDS88802.1
    UniProtKB/Swiss-Prot
    Q99KW3
    Related
    ENSMUSP00000155397.2, ENSMUST00000140228.8
    Conserved Domains (2) summary
    PHA03247
    Location:378895
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:145515
    PHA03307; transcriptional regulator ICP4; Provisional
  3. NM_001039156.1NP_001034245.1  TRIO and F-actin-binding protein isoform 3

    See identical proteins and their annotated locations for NP_001034245.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest protein (isoform 3).
    Source sequence(s)
    BP768417, CX223548, DQ228000
    Consensus CDS
    CCDS37136.1
    UniProtKB/Swiss-Prot
    Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90, Q99KW3
    Related
    ENSMUSP00000105312.4, ENSMUST00000109690.11
    Conserved Domains (4) summary
    PHA03247
    Location:378899
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:145515
    PHA03307; transcriptional regulator ICP4; Provisional
    COG0419
    Location:16672014
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd13275
    Location:14431544
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
  4. NM_138579.4NP_613045.3  TRIO and F-actin-binding protein isoform 5

    See identical proteins and their annotated locations for NP_613045.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon, compared to variant 3, resulting in a shorter protein (isoform 5) when compared to isoform 3.
    Source sequence(s)
    BP768417, BU058377, CA322031, CA751843, CF531000, CF532339, CF533172, CN528900, CX223548, DQ278602
    Consensus CDS
    CCDS37137.1
    UniProtKB/Swiss-Prot
    Q99KW3
    Related
    ENSMUSP00000105311.3, ENSMUST00000109689.9
    Conserved Domains (5) summary
    cd13275
    Location:13971498
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:13971490
    PH; PH domain
    pfam15665
    Location:17261943
    FAM184; Family with sequence similarity 184, A and B
    cl12013
    Location:17211860
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl23720
    Location:18341950
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78831924..78890069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520284.1XP_006520347.1  TRIO and F-actin-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006520347.1

    Conserved Domains (4) summary
    PHA03247
    Location:379900
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:150516
    PHA03307; transcriptional regulator ICP4; Provisional
    COG0419
    Location:16682015
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd13275
    Location:14441545
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
  2. XM_006520286.1XP_006520349.1  TRIO and F-actin-binding protein isoform X3

    Conserved Domains (4) summary
    PHA03247
    Location:379900
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:150516
    PHA03307; transcriptional regulator ICP4; Provisional
    COG0419
    Location:16221969
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd13275
    Location:13981499
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
  3. XM_006520287.1XP_006520350.1  TRIO and F-actin-binding protein isoform X4

    Conserved Domains (4) summary
    PHA03247
    Location:379900
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:150516
    PHA03307; transcriptional regulator ICP4; Provisional
    COG0419
    Location:15961943
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd13275
    Location:13721473
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
  4. XM_036159070.1XP_036014963.1  TRIO and F-actin-binding protein isoform X5

    Conserved Domains (4) summary
    PHA03247
    Location:378899
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:145515
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:15831942
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13275
    Location:13711472
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
  5. XM_036159071.1XP_036014964.1  TRIO and F-actin-binding protein isoform X6

    Conserved Domains (3) summary
    PHA03247
    Location:378899
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:145515
    PHA03307; transcriptional regulator ICP4; Provisional
    cd13275
    Location:13971498
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
  6. XM_006520285.3XP_006520348.1  TRIO and F-actin-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006520348.1

    Conserved Domains (4) summary
    PHA03247
    Location:379900
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:150516
    PHA03307; transcriptional regulator ICP4; Provisional
    COG0419
    Location:16682015
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd13275
    Location:14441545
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
  7. XM_017316365.3XP_017171854.1  TRIO and F-actin-binding protein isoform X2

    UniProtKB/Swiss-Prot
    Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90, Q99KW3
    Conserved Domains (4) summary
    PHA03247
    Location:378899
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:145515
    PHA03307; transcriptional regulator ICP4; Provisional
    COG0419
    Location:16672014
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd13275
    Location:14431544
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
  8. XM_006520289.2XP_006520352.1  TRIO and F-actin-binding protein isoform X7

    Conserved Domains (2) summary
    cd13275
    Location:93194
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02168
    Location:366664
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  9. XM_006520291.4XP_006520354.1  TRIO and F-actin-binding protein isoform X9

    UniProtKB/TrEMBL
    G5E8W1
    Related
    ENSMUSP00000122988.4, ENSMUST00000130663.10
    Conserved Domains (1) summary
    cd13275
    Location:56157
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
  10. XM_036159072.1XP_036014965.1  TRIO and F-actin-binding protein isoform X8

    Conserved Domains (2) summary
    cd13275
    Location:27128
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02168
    Location:300598
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type