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RAB35 RAB35, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 11021, updated on 5-Mar-2024

Summary

Official Symbol
RAB35provided by HGNC
Official Full Name
RAB35, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9774
See related
Ensembl:ENSG00000111737 MIM:604199; AllianceGenome:HGNC:9774
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAY; H-ray; RAB1C
Summary
Enables GTPase activity; guanyl ribonucleotide binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including endosomal transport; plasma membrane to endosome transport; and protein localization to endosome. Located in several cellular components, including clathrin-coated endocytic vesicle; clathrin-coated pit; and intercellular bridge. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 16.4), appendix (RPKM 14.7) and 25 other tissues See more
Orthologs
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Genomic context

See RAB35 in Genome Data Viewer
Location:
12q24.23
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (120095099..120116753, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (120082260..120103928, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120532903..120554557, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7119 Neighboring gene ribosomal protein L35a pseudogene 30 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120423527-120423708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4932 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120426711-120427684 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120427685-120428656 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120431757-120431860 Neighboring gene BICD family like cargo adaptor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7120 Neighboring gene small nucleolar RNA U13 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120490668-120490841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7121 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120528583-120529175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120530601-120531244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120531245-120531888 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120540395-120540996 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120540997-120541598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120541599-120542200 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120542201-120542802 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120547217-120547736 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120547737-120548254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120548255-120548774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7124 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:120553748-120554540 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:120554541-120555332 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4941 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120555445-120555623 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120556125-120556916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7129 Neighboring gene RAB35 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7131 Neighboring gene GCN1 activator of EIF2AK4 Neighboring gene microRNA 4498

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of RAB35, member RAS oncogene family by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Rab protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in antigen processing and presentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to nerve growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endosomal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in plasma membrane to endosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to endosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular exosome HDA PubMed 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
PubMed 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ras-related protein Rab-35
Names
GTP-binding protein RAY
ras-related protein rab-1c (GTP-binding protein ray)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167606.2NP_001161078.1  ras-related protein Rab-35 isoform 2

    See identical proteins and their annotated locations for NP_001161078.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, as compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, as compared to isoform 2.
    Source sequence(s)
    AK001309, AK304620, BP303346, DC370610
    Consensus CDS
    CCDS53836.1
    UniProtKB/Swiss-Prot
    Q15286
    Related
    ENSP00000441883.1, ENST00000534951.5
    Conserved Domains (1) summary
    cl38936
    Location:3117
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_006861.7NP_006852.1  ras-related protein Rab-35 isoform 1

    See identical proteins and their annotated locations for NP_006852.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC004812, AI042456, BC015931
    Consensus CDS
    CCDS41846.1
    UniProtKB/Swiss-Prot
    B2R6E0, B4E390, Q15286
    Related
    ENSP00000229340.5, ENST00000229340.10
    Conserved Domains (1) summary
    cd04110
    Location:3201
    Rab35; Rab GTPase family 35 (Rab35)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    120095099..120116753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    120082260..120103928 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)