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Akr7a5 aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase) [ Mus musculus (house mouse) ]

Gene ID: 110198, updated on 5-Feb-2023

Summary

Official Symbol
Akr7a5provided by MGI
Official Full Name
aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase)provided by MGI
Primary source
MGI:MGI:107796
See related
Ensembl:ENSMUSG00000028743 AllianceGenome:MGI:107796
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Afar; Afar1; Akr7a2; 0610025K21Rik
Summary
Predicted to enable alditol:NADP+ 1-oxidoreductase activity; identical protein binding activity; and phenanthrene-9,10-epoxide hydrolase activity. Located in mitochondrion. Orthologous to several human genes including AKR7A2 (aldo-keto reductase family 7 member A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 97.0), kidney adult (RPKM 73.4) and 19 other tissues See more
Orthologs
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Genomic context

See Akr7a5 in Genome Data Viewer
Location:
4 D3; 4 70.64 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (139038005..139046097)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (139310720..139318786)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16287 Neighboring gene capping actin protein of muscle Z-line subunit beta Neighboring gene solute carrier family 66 member 1 Neighboring gene cyclin D3, pseudogene Neighboring gene mRNA turnover 4, ribosome maturation factor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alditol:NADP+ 1-oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
enables aldo-keto reductase (NADP) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables phenanthrene-9,10-epoxide hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
aflatoxin B1 aldehyde reductase member 2
Names
SSA reductase
succinic semialdehyde reductase
NP_079613.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025337.3NP_079613.3  aflatoxin B1 aldehyde reductase member 2

    See identical proteins and their annotated locations for NP_079613.3

    Status: VALIDATED

    Source sequence(s)
    AK143203, BE652423
    Consensus CDS
    CCDS18844.1
    UniProtKB/Swiss-Prot
    Q8CG76, Q9D157
    Related
    ENSMUSP00000073459.7, ENSMUST00000073787.7
    Conserved Domains (2) summary
    cd06660
    Location:46354
    Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...
    COG0667
    Location:46363
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    139038005..139046097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_390721.5 RNA Sequence