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Fdps farnesyl diphosphate synthetase [ Mus musculus (house mouse) ]

Gene ID: 110196, updated on 8-Jan-2023

Summary

Official Symbol
Fdpsprovided by MGI
Official Full Name
farnesyl diphosphate synthetaseprovided by MGI
Primary source
MGI:MGI:104888
See related
Ensembl:ENSMUSG00000059743 AllianceGenome:MGI:104888
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fdpsl1; mKIAA1293; 6030492I17Rik
Summary
Predicted to enable dimethylallyltranstransferase activity and geranyltranstransferase activity. Predicted to be involved in farnesyl diphosphate biosynthetic process; positive regulation of cell growth involved in cardiac muscle cell development; and positive regulation of cholesterol biosynthetic process. Predicted to act upstream of or within cholesterol biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human FDPS (farnesyl diphosphate synthase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 129.0), liver adult (RPKM 110.9) and 27 other tissues See more
Orthologs
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Genomic context

See Fdps in Genome Data Viewer
Location:
3 F1; 3 39.01 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89000895..89009274, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89093588..89101967, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ASH1 like histone lysine methyltransferase Neighboring gene predicted gene, 24403 Neighboring gene RUN and SH3 domain containing 1 Neighboring gene predicted gene, 22935 Neighboring gene predicted gene, 29704 Neighboring gene pyruvate kinase liver and red blood cell Neighboring gene hyperpolarization-activated, cyclic nucleotide-gated K+ 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC107162

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dimethylallyltranstransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables geranyltranstransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables geranyltranstransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
farnesyl pyrophosphate synthase
Names
(2E,6E)-farnesyl diphosphate synthase
CR 39
FPP synthase
FPP synthetase
FPS
cholesterol-regulated 39 kDa protein
dimethylallyltranstransferase
farnesyl diphosphate synthase
farnesyl pyrophosphate synthetase
geranyltranstransferase
NP_001240680.1
NP_608219.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253751.1NP_001240680.1  farnesyl pyrophosphate synthase isoform 1 precursor

    See identical proteins and their annotated locations for NP_001240680.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC140468, BC048497, BE994006, BY144580, CJ082322
    UniProtKB/Swiss-Prot
    Q920E5
    Conserved Domains (2) summary
    pfam00348
    Location:117378
    polyprenyl_synt; Polyprenyl synthetase
    pfam07462
    Location:72144
    MSP1_C; Merozoite surface protein 1 (MSP1) C-terminus
  2. NM_134469.4NP_608219.1  farnesyl pyrophosphate synthase isoform 2

    See identical proteins and their annotated locations for NP_608219.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    BC048497, BE994006, CJ082244
    Consensus CDS
    CCDS17488.1
    UniProtKB/Swiss-Prot
    Q920E5
    UniProtKB/TrEMBL
    Q4FJN9
    Related
    ENSMUSP00000080531.9, ENSMUST00000081848.13
    Conserved Domains (1) summary
    pfam00348
    Location:50311
    polyprenyl_synt; Polyprenyl synthetase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89000895..89009274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_180985.1: Suppressed sequence

    Description
    NM_180985.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.