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Manba mannosidase, beta A, lysosomal [ Mus musculus (house mouse) ]

Gene ID: 110173, updated on 5-Mar-2024

Summary

Official Symbol
Manbaprovided by MGI
Official Full Name
mannosidase, beta A, lysosomalprovided by MGI
Primary source
MGI:MGI:88175
See related
Ensembl:ENSMUSG00000028164 AllianceGenome:MGI:88175
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bmn; 2410030O07Rik; B930014J03Rik
Summary
Enables beta-mannosidase activity. Involved in glycoprotein catabolic process. Located in extracellular space. Is expressed in several structures, including alimentary system; ear; genitourinary system; heart; and nervous system. Used to study beta-mannosidosis. Human ortholog(s) of this gene implicated in beta-mannosidosis. Orthologous to human MANBA (mannosidase beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 10.2), kidney adult (RPKM 8.8) and 28 other tissues See more
Orthologs
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Genomic context

See Manba in Genome Data Viewer
Location:
3 G3; 3 62.65 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (135191367..135277165)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (135485611..135571404)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930539J05 gene Neighboring gene STARR-positive B cell enhancer ABC_E1026 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:135101299-135101408 Neighboring gene STARR-positive B cell enhancer ABC_E6132 Neighboring gene ubiquitin-conjugating enzyme E2D 3 Neighboring gene predicted gene, 30992 Neighboring gene STARR-seq mESC enhancer starr_09062 Neighboring gene ornithine decarboxylase antizyme 2, pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:135244702-135244889 Neighboring gene STARR-positive B cell enhancer ABC_E10216 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Neighboring gene STARR-positive B cell enhancer ABC_E829 Neighboring gene STARR-positive B cell enhancer ABC_E4597 Neighboring gene STARR-positive B cell enhancer ABC_E11220 Neighboring gene STARR-positive B cell enhancer ABC_E1267 Neighboring gene STARR-seq mESC enhancer starr_09070 Neighboring gene STARR-positive B cell enhancer ABC_E8806 Neighboring gene RIKEN cDNA 4933401H06 gene Neighboring gene solute carrier family 39 (metal ion transporter), member 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables beta-mannosidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables beta-mannosidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables beta-mannosidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
 
enables mannose binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within glycoprotein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glycoprotein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in oligosaccharide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in lysosomal lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
beta-mannosidase
Names
lysosomal beta A mannosidase
mannanase
mannase
NP_081564.3
XP_006500971.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027288.3NP_081564.3  beta-mannosidase precursor

    See identical proteins and their annotated locations for NP_081564.3

    Status: VALIDATED

    Source sequence(s)
    AF306557, BB782198, BU757579
    Consensus CDS
    CCDS17857.1
    UniProtKB/Swiss-Prot
    Q3TDB3, Q3TLS7, Q3UQT5, Q8K2I4, Q99MS1, Q9CRH3
    UniProtKB/TrEMBL
    A0A0R4J092
    Related
    ENSMUSP00000029814.10, ENSMUST00000029814.10
    Conserved Domains (3) summary
    COG3250
    Location:24694
    LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]
    pfam02837
    Location:80136
    Glyco_hydro_2_N; Glycosyl hydrolases family 2, sugar binding domain
    cl23725
    Location:343457
    Glyco_hydro_1; Glycosyl hydrolase family 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    135191367..135277165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500908.3XP_006500971.1  beta-mannosidase isoform X1

    Conserved Domains (3) summary
    cl30613
    Location:8392
    LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]
    pfam17753
    Location:499575
    Ig_mannosidase; Ig-fold domain
    pfam17786
    Location:398493
    Mannosidase_ig; Mannosidase Ig/CBM-like domain

RNA

  1. XR_867210.4 RNA Sequence