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Dut deoxyuridine triphosphatase [ Mus musculus (house mouse) ]

Gene ID: 110074, updated on 26-Sep-2022

Summary

Official Symbol
Dutprovided by MGI
Official Full Name
deoxyuridine triphosphataseprovided by MGI
Primary source
MGI:MGI:1346051
See related
Ensembl:ENSMUSG00000027203 AllianceGenome:MGI:1346051
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dutp; dUTPase; D2Bwg0749e; 5031412I06Rik; 5133400F09Rik
Summary
Predicted to enable several functions, including dUTP diphosphatase activity; magnesium ion binding activity; and peroxisome proliferator activated receptor binding activity. Predicted to be involved in pyrimidine deoxyribonucleotide metabolic process and regulation of protein-containing complex assembly. Located in mitochondrion. Is expressed in central nervous system and retina. Orthologous to human DUT (deoxyuridine triphosphatase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 32.2), liver E14 (RPKM 31.2) and 28 other tissues See more
Orthologs
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Genomic context

See Dut in Genome Data Viewer
Location:
2 F1; 2 61.33 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (125089168..125100969)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (125247248..125259049)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 12, member 1 Neighboring gene predicted gene, 46760 Neighboring gene predicted gene 14002 Neighboring gene fibrillin 1 Neighboring gene centrosomal protein 152 Neighboring gene 60S ribosomal protein L27 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dUTP diphosphatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peroxisome proliferator activated receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables pyrimidine deoxyribonucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in dTMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in dUMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in dUTP catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
deoxyuridine 5'-triphosphate nucleotidohydrolase
Names
deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
NP_001153118.1
NP_076084.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159646.1NP_001153118.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 1

    See identical proteins and their annotated locations for NP_001153118.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK135438, AK153285
    Consensus CDS
    CCDS50695.1
    UniProtKB/TrEMBL
    Q8VCG1, Q9CQ43
    Related
    ENSMUSP00000080767.8, ENSMUST00000082122.14
    Conserved Domains (1) summary
    cl00493
    Location:61198
    trimeric_dUTPase; Trimeric dUTP diphosphatases
  2. NM_023595.6NP_076084.2  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 2

    See identical proteins and their annotated locations for NP_076084.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK077244, AK153285
    Consensus CDS
    CCDS16675.1
    UniProtKB/Swiss-Prot
    Q9JJ44
    UniProtKB/TrEMBL
    Q9CQ43
    Related
    ENSMUSP00000057854.9, ENSMUST00000051605.9
    Conserved Domains (1) summary
    cl00493
    Location:23160
    trimeric_dUTPase; Trimeric dUTP diphosphatases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    125089168..125100969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)