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CCDC85B coiled-coil domain containing 85B [ Homo sapiens (human) ]

Gene ID: 11007, updated on 5-Aug-2022

Summary

Official Symbol
CCDC85Bprovided by HGNC
Official Full Name
coiled-coil domain containing 85Bprovided by HGNC
Primary source
HGNC:HGNC:24926
See related
Ensembl:ENSG00000175602 MIM:605360; AllianceGenome:HGNC:24926
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIPA
Summary
Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to hepatitis delta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication in vitro. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See CCDC85B in Genome Data Viewer
Location:
11q13.1
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (65890673..65891635)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (65883735..65884697)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65658144..65659106)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MUS81 structure-specific endonuclease subunit Neighboring gene EGF containing fibulin extracellular matrix protein 2 Neighboring gene cathepsin W Neighboring gene FGF1 intracellular binding protein Neighboring gene FOS like 1, AP-1 transcription factor subunit Neighboring gene CRISPRi-validated cis-regulatory element chr11.3338

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables delta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
coiled-coil domain-containing protein 85B
Names
delta-interacting protein A
hepatitis delta antigen-interacting protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006848.3NP_006839.2  coiled-coil domain-containing protein 85B

    See identical proteins and their annotated locations for NP_006839.2

    Status: VALIDATED

    Source sequence(s)
    AI583181, BC008796
    Consensus CDS
    CCDS8120.1
    UniProtKB/Swiss-Prot
    Q15834, Q96HA0
    Related
    ENSP00000311695.2, ENST00000312579.4
    Conserved Domains (1) summary
    pfam10226
    Location:5178
    DUF2216; Uncharacterized conserved proteins (DUF2216)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    65890673..65891635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    65883735..65884697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)