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Tcrg T cell receptor gamma chain [ Mus musculus (house mouse) ]

Gene ID: 110067, updated on 23-Jun-2021

Summary

Official Symbol
Tcrgprovided by MGI
Official Full Name
T cell receptor gamma chainprovided by MGI
Primary source
MGI:MGI:98623
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TCRGV1S1; TCRGV2S1; TCRGV3S1; TCRGV5S3
Summary
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor gamma locus. The gamma locus includes V (variable), J (joining), and C (constant) segments. During T cell development, the gamma chain is synthesized by a recombination event at the DNA level joining a V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random addition of nucleotides by terminal deoxynucleotidyltransferase. [provided by RefSeq, Jul 2008]
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Genomic context

See Tcrg in Genome Data Viewer
Location:
13 A2; 13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (19362212..19540646)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (19178042..19356476)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (19269911..19448345)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53776 Neighboring gene amphiphysin Neighboring gene ribosomal protein 10 pseudogene Neighboring gene predicted gene, 31887 Neighboring gene T cell receptor gamma, variable 7 Neighboring gene T cell receptor gamma, variable 4 Neighboring gene T cell receptor gamma, variable 6 Neighboring gene T cell receptor gamma, variable 5 Neighboring gene T cell receptor gamma joining 1 Neighboring gene T cell receptor gamma, constant 1 Neighboring gene T cell receptor gamma, variable 3 Neighboring gene T cell receptor gamma joining 3 Neighboring gene T cell receptor gamma, constant 3 Neighboring gene T cell receptor gamma, constant 2 Neighboring gene T cell receptor gamma joining 2 Neighboring gene T cell receptor gamma variable 2 Neighboring gene STARD3 N-terminal like Neighboring gene T cell receptor gamma, variable 1 Neighboring gene T cell receptor gamma joining 4 Neighboring gene T cell receptor gamma, constant 4 Neighboring gene predicted gene, 40827 Neighboring gene cofilin 1, non-muscle pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Other Names

  • TCR V gamma 1.3
  • TCR V gamma 2
  • TCR V gamma 3
  • TCR V gamma 4

General protein information

Names
T cell receptor gamma chain
TCR V gamma 1.3
TCR V gamma 2
TCR V gamma 3
TCR V gamma 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007033.1 

    Range
    501..178935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    19362212..19540646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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