Dek DEK proto-oncogene (DNA binding) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dekprovided by MGI
Official Full Name: DEK proto-oncogene (DNA binding)provided by MGI
Primary source: MGI:MGI:1926209
See related: Ensembl:ENSMUSG00000021377 AllianceGenome:MGI:1926209
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D13H6S231E; 1810019E15Rik
Summary: Predicted to enable histone binding activity. Acts upstream of or within regulation of double-strand break repair via nonhomologous end joining. Located in contractile fiber and nucleus. Is expressed in several structures, including early conceptus; limb; liver; oocyte; and retina. Orthologous to human DEK (DEK proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14 (RPKM 94.0), liver E14.5 (RPKM 74.8) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A5; 13 24.5 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (47238243..47261134, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (47084767..47107530, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-181-5p attenuates neutrophilic inflammation in asthma by targeting DEK.
Title: miR-181-5p attenuates neutrophilic inflammation in asthma by targeting DEK.
Novel DEK-Targeting Aptamer Delivered by a Hydrogel Microneedle Attenuates Collagen-Induced Arthritis.
Title: Novel DEK-Targeting Aptamer Delivered by a Hydrogel Microneedle Attenuates Collagen-Induced Arthritis.
Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis.
Title: Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis.
Dek Modulates Global Intron Retention during Muscle Stem Cells Quiescence Exit.
Title: Dek Modulates Global Intron Retention during Muscle Stem Cells Quiescence Exit.
Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling.
Title: Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling.
These findings define DEK as an important and multifunctional mediator of homologous recombination.
Title: DEK is required for homologous recombination repair of DNA breaks.
DEK is crucial to the development of arthritis in mouse models, thus making it an appropriate target for aptamer-based therapy.
Title: DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis.
DEK was expressed throughout the brain in both sexes, including the medial prefrontal cortex (prelimbic, infralimbic and dorsal peduncular). DEK was also abundant in all amygdalar subdivisions (basolateral, central and medial) and in the hippocampus including the CA1, CA2, CA3, dentate gyrus (DG), ventral subiculum and entorhinal cortex.
Title: Neuroanatomical Distribution of DEK Protein in Corticolimbic Circuits Associated with Learning and Memory in Adult Male and Female Mice.
Dek contributes to esophageal squamous cell carcinoma tumorigenesis at least partially through keratinocyte intrinsic pathways which promote cellular and tumor growth.
Title: Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence.
Data suggests that DEK participates in the process of embryo implantation and might play a role in influencing stromal cell decidualization through mediating cell proliferation, apoptosis and DNA damage.
Title: Roles of DEK in the endometrium of mice in early pregnancy.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Dek gene: The Dek gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 481 organisms have orthologs with human gene Dek
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables histone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell quiescence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of histone acetylation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase I	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
involved_in regulation of double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within regulation of double-strand break repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of double-strand break repair via nonhomologous end joining	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of B-WICH complex	ISO Inferred from Sequence Orthology more info
located_in contractile fiber	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein DEK

Names: DEK oncogene (DNA binding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025900.2 → NP_080176.2 protein DEK

See identical proteins and their annotated locations for NP_080176.2

Status: VALIDATED

Source sequence(s)

AK033451, AK141790, AV449751, BU920290, BY429959

Consensus CDS

CCDS26490.1

UniProtKB/Swiss-Prot

Q7TNV0, Q8BZV6

UniProtKB/TrEMBL

Q3UR53

Related

ENSMUSP00000021807.7, ENSMUST00000021807.13

Conserved Domains (2) summary

smart00513
Location:153 → 187

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

pfam08766
Location:325 → 379

DEK_C; DEK C terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

47238243..47261134 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157833.1 → XP_036013726.1 protein DEK isoform X1

UniProtKB/Swiss-Prot

Q8BZV6

Conserved Domains (2) summary

smart00513
Location:153 → 187

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

pfam08766
Location:325 → 379

DEK_C; DEK C terminal domain