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SLC27A4 solute carrier family 27 member 4 [ Homo sapiens (human) ]

Gene ID: 10999, updated on 7-Oct-2018

Summary

Official Symbol
SLC27A4provided by HGNC
Official Full Name
solute carrier family 27 member 4provided by HGNC
Primary source
HGNC:HGNC:10998
See related
Ensembl:ENSG00000167114 MIM:604194; Vega:OTTHUMG00000020746
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IPS; FATP4; ACSVL4
Summary
This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010]
Expression
Broad expression in duodenum (RPKM 32.2), small intestine (RPKM 21.2) and 24 other tissues See more
Orthologs

Genomic context

See SLC27A4 in Genome Data Viewer
Location:
9q34.11
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (128340516..128361470)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131102839..131123749)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene TruB pseudouridine synthase family member 2 Neighboring gene coenzyme Q4 Neighboring gene transfer RNA-Arg (TCT) 3-1 Neighboring gene TMSB4X pseudogene 4 Neighboring gene ubiquitin related modifier 1 Neighboring gene microRNA 219a-2 Neighboring gene microRNA 219b

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with solute carrier family 27 (fatty acid transporter), member 4 (SLC27A4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Fat digestion and absorption, organism-specific biosystem (from KEGG)
    Fat digestion and absorption, organism-specific biosystemFat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, die...
  • Fat digestion and absorption, conserved biosystem (from KEGG)
    Fat digestion and absorption, conserved biosystemFat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, die...
  • Insulin resistance, organism-specific biosystem (from KEGG)
    Insulin resistance, organism-specific biosystemInsulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic...
  • PPAR signaling pathway, organism-specific biosystem (from KEGG)
    PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPAR signaling pathway, conserved biosystem (from KEGG)
    PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
    SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
  • Transport of fatty acids, organism-specific biosystem (from REACTOME)
    Transport of fatty acids, organism-specific biosystemLong chain fatty acids (LCFAs) are involved in many cellular functions. They can be used as an important source of energy by skeletal muscle and heart tissues. Also, they are used in the production o...
  • Transport of vitamins, nucleosides, and related molecules, organism-specific biosystem (from REACTOME)
    Transport of vitamins, nucleosides, and related molecules, organism-specific biosystemThis pathway groups the processes mediated by SLC transporters, by which vitamins and cofactors, as well as nucleosides, nucleotides, nucleobases, and related molecules cross lipid bilayer membranes.

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
fatty acid transmembrane transporter activity TAS
Traceable Author Statement
more info
 
long-chain fatty acid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
very long-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
fatty acid transport TAS
Traceable Author Statement
more info
PubMed 
lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
long-chain fatty acid import IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty acid import IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty acid transport TAS
Traceable Author Statement
more info
 
medium-chain fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to nutrient IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
skin development IEA
Inferred from Electronic Annotation
more info
 
very long-chain fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
brush border membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
microvillus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
long-chain fatty acid transport protein 4
Names
solute carrier family 27 (fatty acid transporter), member 4
NP_005085.2
XP_016869711.1
XP_024303159.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017057.1 RefSeqGene

    Range
    5001..25911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005094.3NP_005085.2  long-chain fatty acid transport protein 4

    See identical proteins and their annotated locations for NP_005085.2

    Status: REVIEWED

    Source sequence(s)
    AA350218, AI478495, AK290222, BC065003, H16504
    Consensus CDS
    CCDS6899.1
    UniProtKB/Swiss-Prot
    Q6P1M0
    UniProtKB/TrEMBL
    A0A024R8D2
    Related
    ENSP00000300456.3, OTTHUMP00000022264, ENST00000300456.4, OTTHUMT00000054432
    Conserved Domains (1) summary
    cd05939
    Location:99608
    hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    128340516..128361470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447391.1XP_024303159.1  long-chain fatty acid transport protein 4 isoform X1

    Conserved Domains (1) summary
    cd05939
    Location:99608
    hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
  2. XM_017014222.1XP_016869711.1  long-chain fatty acid transport protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q6P1M0
    UniProtKB/TrEMBL
    A0A024R8D2
    Conserved Domains (1) summary
    cd05939
    Location:99608
    hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
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