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SLC27A4 solute carrier family 27 member 4 [ Homo sapiens (human) ]

Gene ID: 10999, updated on 6-May-2021

Summary

Official Symbol
SLC27A4provided by HGNC
Official Full Name
solute carrier family 27 member 4provided by HGNC
Primary source
HGNC:HGNC:10998
See related
Ensembl:ENSG00000167114 MIM:604194
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IPS; FATP4; ACSVL4
Summary
This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010]
Expression
Broad expression in duodenum (RPKM 32.2), small intestine (RPKM 21.2) and 24 other tissues See more
Orthologs
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Genomic context

See SLC27A4 in Genome Data Viewer
Location:
9q34.11
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (128340516..128361470)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131102806..131123749)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene coenzyme Q4 Neighboring gene tRNA-Arg (anticodon TCT) 3-1 Neighboring gene TMSB4X pseudogene 4 Neighboring gene ubiquitin related modifier 1 Neighboring gene microRNA 219a-2 Neighboring gene microRNA 219b

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with solute carrier family 27 (fatty acid transporter), member 4 (SLC27A4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables arachidonate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables long-chain fatty acid transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables oleate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables oleoyl-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables oleoyl-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables palmitoyl-CoA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables very long-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within activation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fatty acid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose import in response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lipid transport across blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-chain fatty acid import into cell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in long-chain fatty acid import into cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-chain fatty acid import into cell ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-chain fatty acid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-chain fatty acid transport TAS
Traceable Author Statement
more info
 
involved_in medium-chain fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to nutrient IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in skin development IEA
Inferred from Electronic Annotation
more info
 
involved_in transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
involved_in very long-chain fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in brush border membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
long-chain fatty acid transport protein 4
Names
arachidonate--CoA ligase
long-chain-fatty-acid--CoA ligase
solute carrier family 27 (fatty acid transporter), member 4
very long-chain acyl-CoA synthetase 4
NP_005085.2
XP_016869711.1
XP_024303159.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017057.1 RefSeqGene

    Range
    4968..25911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005094.4NP_005085.2  long-chain fatty acid transport protein 4

    See identical proteins and their annotated locations for NP_005085.2

    Status: REVIEWED

    Source sequence(s)
    AA350218, AI478495, AK290222, AL359091, BC065003, H16504
    Consensus CDS
    CCDS6899.1
    UniProtKB/Swiss-Prot
    Q6P1M0
    UniProtKB/TrEMBL
    A0A024R8D2
    Related
    ENSP00000300456.3, ENST00000300456.5
    Conserved Domains (1) summary
    cd05939
    Location:99608
    hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    128340516..128361470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447391.1XP_024303159.1  long-chain fatty acid transport protein 4 isoform X1

    Conserved Domains (1) summary
    cd05939
    Location:99608
    hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
  2. XM_017014222.1XP_016869711.1  long-chain fatty acid transport protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q6P1M0
    UniProtKB/TrEMBL
    A0A024R8D2
    Conserved Domains (1) summary
    cd05939
    Location:99608
    hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
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