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SLC27A5 solute carrier family 27 member 5 [ Homo sapiens (human) ]

Gene ID: 10998, updated on 11-Apr-2024

Summary

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Official Symbol
SLC27A5provided by HGNC
Official Full Name
solute carrier family 27 member 5provided by HGNC
Primary source
HGNC:HGNC:10999
See related
Ensembl:ENSG00000083807 MIM:603314; AllianceGenome:HGNC:10999
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAL; ACSB; BACS; FATP5; ACSVL6; FACVL3; FATP-5; VLACSR; VLCSH2; VLCS-H2
Summary
The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 126.6) and testis (RPKM 2.0) See more
Orthologs
mouse all
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Genomic context

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Location:
19q13.43
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58498333..58511992, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61594402..61607985, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (59009700..59023359, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268251 Neighboring gene zinc finger protein 446 Neighboring gene RNA, U6 small nuclear 1337, pseudogene Neighboring gene Sharpr-MPRA regulatory region 4347 Neighboring gene RNA, 7SL, cytoplasmic 693, pseudogene Neighboring gene uncharacterized LOC105372485 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15206 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:59017967-59018180 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59023062-59023576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11087 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11088 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59029424-59030084 Neighboring gene zinc finger and BTB domain containing 45 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15207 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:59049840-59050470 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:59050471-59051099 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:59054606-59055110 Neighboring gene RNA, 7SL, cytoplasmic 525, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SLC27A5 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by downregulating glutathione reductase. Xu FL, et al. Cell Death Dis, 2023 Jan 12. PMID 36635256, Free PMC Article
  2. Hepatic FATP5 expression is associated with histological progression and loss of hepatic fat in NAFLD patients. Enooku K, et al. J Gastroenterol, 2020 Feb. PMID 31602526
  3. Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiency. Setchell KD, et al. Gastroenterology, 2013 May. PMID 23415802, Free PMC Article
  4. Bile acid-CoA ligase deficiency--a new inborn error of bile acid metabolism. Chong CP, et al. J Inherit Metab Dis, 2012 May. PMID 22089923
  5. A promoter polymorphism in the liver-specific fatty acid transport protein 5 is associated with features of the metabolic syndrome and steatosis. Auinger A, et al. Horm Metab Res, 2010 Nov. PMID 20945272

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Metabolic Enzyme SLC27A5 Regulates PIP4K2A pre-mRNA Splicing as a Noncanonical Mechanism to Suppress Hepatocellular Carcinoma Metastasis.
    Title: Metabolic Enzyme SLC27A5 Regulates PIP4K2A pre-mRNA Splicing as a Noncanonical Mechanism to Suppress Hepatocellular Carcinoma Metastasis.
  2. Copper metabolism-related risk score identifies hepatocellular carcinoma subtypes and SLC27A5 as a potential regulator of cuproptosis.
    Title: Copper metabolism-related risk score identifies hepatocellular carcinoma subtypes and SLC27A5 as a potential regulator of cuproptosis.
  3. Loss of SLC27A5 Activates Hepatic Stellate Cells and Promotes Liver Fibrosis via Unconjugated Cholic Acid.
    Title: Loss of SLC27A5 Activates Hepatic Stellate Cells and Promotes Liver Fibrosis via Unconjugated Cholic Acid.
  4. SLC27A5 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by downregulating glutathione reductase.
    Title: SLC27A5 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by downregulating glutathione reductase.
  5. SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC.
    Title: SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC.
  6. Hepatic FATP5 expression is associated with histological progression and loss of hepatic fat in NAFLD patients.
    Title: Hepatic FATP5 expression is associated with histological progression and loss of hepatic fat in NAFLD patients.
  7. Based on a study of 10 pediatric patients, genetic defects that disrupt bile acid amidation cause fat-soluble vitamin deficiency and growth failure, indicating the importance of bile acid conjugation in lipid absorption.
    Title: Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiency.
  8. Bile acid-CoA ligase deficiency is a new inborn error of bile acid metabolism [case report]
    Title: Bile acid-CoA ligase deficiency--a new inborn error of bile acid metabolism.
  9. A promoter polymorphism in the FATP5 is associated with the metabolic syndrome and steatosis.
    Title: A promoter polymorphism in the liver-specific fatty acid transport protein 5 is associated with features of the metabolic syndrome and steatosis.
  10. Observational study of gene-disease association. (HuGE Navigator)
    Title: A promoter polymorphism in the liver-specific fatty acid transport protein 5 is associated with features of the metabolic syndrome and steatosis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22987

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cholate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fatty acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid-CoA ligase activity TAS
Traceable Author Statement
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables very long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in bile acid and bile salt transport TAS
Traceable Author Statement
more info
  
involved_in bile acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in bile acid biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in bile acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of localization in cell IEA
Inferred from Electronic Annotation
more info
  
involved_in ketone body biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid import across plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid import into cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride mobilization IEA
Inferred from Electronic Annotation
more info
  
involved_in very long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
long-chain fatty acid transport protein 5
Names
BA-CoA ligase
VLACS-related
bile acid-CoA ligase
bile acyl-CoA synthetase
cholate--CoA ligase
fatty acid transport protein 5
fatty-acid-Coenzyme A ligase, very long-chain 3
long-chain-fatty-acid--CoA ligase
solute carrier family 27 (fatty acid transporter), member 5
very long-chain acyl-CoA synthetase homolog 2
very long-chain acyl-CoA synthetase-related protein
NP_001308125.1
NP_036386.1
XP_011524666.1
XP_016881703.1
XP_054175600.1
XP_054175601.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047124.1 RefSeqGene

    Range
    5074..18733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321196.2 → NP_001308125.1  long-chain fatty acid transport protein 5 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AF064255, AK298446, BU688212
    Consensus CDS
    CCDS82415.1
    UniProtKB/Swiss-Prot
    Q9Y2P5
    Related
    ENSP00000470368.1, ENST00000601355.1
    Conserved Domains (1) summary
    cl17068
    Location:146 → 596
    AFD_class_I; Adenylate forming domain, Class I superfamily

  2. NM_012254.3 → NP_036386.1  long-chain fatty acid transport protein 5 isoform 1

    See identical proteins and their annotated locations for NP_036386.1

    Status: REVIEWED

    Source sequence(s)
    AK123036, BX103174
    Consensus CDS
    CCDS12983.1
    UniProtKB/Swiss-Prot
    B3KVP6, B4DPQ1, Q9Y2P5
    Related
    ENSP00000263093.2, ENST00000263093.7
    Conserved Domains (2) summary
    cd05938
    Location:140 → 680
    hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins
    PRK08279
    Location:87 → 690
    PRK08279; long-chain-acyl-CoA synthetase; Validated

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    58498333..58511992 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526364.3 → XP_011524666.1  long-chain fatty acid transport protein 5 isoform X1

    Conserved Domains (2) summary
    pfam00501
    Location:120 → 558
    AMP-binding; AMP-binding enzyme
    cl17068
    Location:140 → 592
    AFD_class_I; Adenylate forming domain, Class I superfamily

  2. XM_017026214.3 → XP_016881703.1  long-chain fatty acid transport protein 5 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    61594402..61607985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319625.1 → XP_054175600.1  long-chain fatty acid transport protein 5 isoform X1

  2. XM_054319626.1 → XP_054175601.1  long-chain fatty acid transport protein 5 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2P5.1 GenPept UniProtKB/Swiss-Prot:Q9Y2P5

Gene LinkOut

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