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SCO4159 transcriptional regulator [ Streptomyces coelicolor A3(2) ]

Gene ID: 1099599, discontinued on 9-Sep-2022
  • This record was discontinued.

Summary

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Gene symbol
SCO4159
Gene description
transcriptional regulator
Locus tag
SCO4159
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Streptomyces coelicolor A3(2) (serovar: A3(2))
Lineage
Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group
Also known as
glnR; SCD84.26c
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Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003888.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Global nitrogen regulator GlnR interacts with the promoter regions of the gene encoding lysine deacetylase and activates its transcription. Signal transduction mechanism of regulating protein deacetylation in response to extracellular nitrogen availability is mediated by the nutrient-sensing pleiotropic regulator GlnR.
    Title: Nitrogen regulator GlnR directly controls transcription of genes encoding lysine deacetylases in Actinobacteria.
  2. data show AfsQ1/Q2 can function as a repressor for nitrogen assimilation and AfsQ1 can compete with GlnR for the promoter regions of glnA and nirB, suggesting cross-regulation between AfsQ1/Q2 and GlnR in nitrogen metabolism
    Title: Identification of two-component system AfsQ1/Q2 regulon and its cross-regulation with GlnR in Streptomyces coelicolor.
  3. Both PhoP and AfsR proteins are able to bind to overlapping regions within the glnR promoter producing different effects.
    Title: Overlapping binding of PhoP and AfsR to the promoter region of glnR in Streptomyces coelicolor.
  4. 10 new GlnR targets were identified, including enzymes for ammonium assimilation, nitrite reduction, urea cleavage & a number of biochemically uncharacterized proteins; for the GlnR regulon, a GlnR binding site was found
    Title: The Streptomyces coelicolor GlnR regulon: identification of new GlnR targets and evidence for a central role of GlnR in nitrogen metabolism in actinomycetes.
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General gene information

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Homology

Miscellaneous features

  • Loc: c4576545-4576333 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal, score 132.50, E-value 2.4e-38

General protein information

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Names
transcriptional regulator
NP_628336.1
  • SCD84.26c, glnR, transcriptional regulatory protein, len: 267 aa; identical to previously sequenced SW:GLNR_STRCO (EMBL:L03213) Streptomyces coelicolor transcriptional regulatory protein GlnR. Contains Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003888.3 Reference assembly

    Range
    4576177..4576980 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_628336.1 transcriptional regulator [Streptomyces coelicolor A3(2)]

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05943.1

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