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SDS serine dehydratase [ Homo sapiens (human) ]

Gene ID: 10993, updated on 7-Jun-2020

Summary

Official Symbol
SDSprovided by HGNC
Official Full Name
serine dehydrataseprovided by HGNC
Primary source
HGNC:HGNC:10691
See related
Ensembl:ENSG00000135094 MIM:182128
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDH
Summary
This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 130.0) and brain (RPKM 4.0) See more
Orthologs

Genomic context

See SDS in Genome Data Viewer
Location:
12q24.13
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (113392445..113403887, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (113830250..113841692, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 8 member B1 Neighboring gene uncharacterized LOC105369989 Neighboring gene phospholipase B domain containing 2 Neighboring gene serine dehydratase like Neighboring gene LIM homeobox 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-serine ammonia-lyase activity IDA
Inferred from Direct Assay
more info
PubMed 
L-threonine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
L-serine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
L-threonine catabolic process to glycine TAS
Traceable Author Statement
more info
 
gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
isoleucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pyruvate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
threonine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
threonine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
L-serine dehydratase/L-threonine deaminase
Names
L-serine ammonia-lyase
L-serine deaminase
L-serine dehydratase
L-threonine dehydratase
TDH
NP_006834.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006843.3NP_006834.2  L-serine dehydratase/L-threonine deaminase

    See identical proteins and their annotated locations for NP_006834.2

    Status: REVIEWED

    Source sequence(s)
    BC020750, BG534053, BG566257, BU740747, J05037
    Consensus CDS
    CCDS9169.1
    UniProtKB/Swiss-Prot
    P20132
    UniProtKB/TrEMBL
    Q8WW81
    Related
    ENSP00000257549.4, ENST00000257549.9
    Conserved Domains (2) summary
    cd06448
    Location:10320
    L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.
    pfam00291
    Location:5304
    PALP; Pyridoxal-phosphate dependent enzyme

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    113392445..113403887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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