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SLC38A3 solute carrier family 38 member 3 [ Homo sapiens (human) ]

Gene ID: 10991, updated on 18-Aug-2020

Summary

Official Symbol
SLC38A3provided by HGNC
Official Full Name
solute carrier family 38 member 3provided by HGNC
Primary source
HGNC:HGNC:18044
See related
Ensembl:ENSG00000188338 MIM:604437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G17; SN1; NAT1; SNAT3
Expression
Biased expression in liver (RPKM 98.6) and brain (RPKM 9.7) See more
Orthologs

Genomic context

See SLC38A3 in Genome Data Viewer
Location:
3p21.31
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (50205268..50221486)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (50242692..50258406)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SEMA3F antisense RNA 1 Neighboring gene basic proline-rich protein-like Neighboring gene semaphorin 3F Neighboring gene G protein subunit alpha transducin 1 Neighboring gene microRNA 5787 Neighboring gene G protein subunit alpha i2 Neighboring gene SEMA3B antisense RNA 1 (head to head)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-alanine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
L-asparagine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-asparagine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
L-glutamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-glutamine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
L-histidine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-histidine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amino acid transmembrane transporter activity TAS
Traceable Author Statement
more info
 
antiporter activity IEA
Inferred from Electronic Annotation
more info
 
symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
L-alanine transport IDA
Inferred from Direct Assay
more info
PubMed 
L-histidine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amino acid transport TAS
Traceable Author Statement
more info
 
asparagine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
asparagine transport IDA
Inferred from Direct Assay
more info
PubMed 
brain development IEA
Inferred from Electronic Annotation
more info
 
cellular response to potassium ion starvation IEA
Inferred from Electronic Annotation
more info
 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
glutamine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamine transport IDA
Inferred from Direct Assay
more info
PubMed 
histidine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histidine transport IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of glutamine transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter in response to acidic pH IEA
Inferred from Electronic Annotation
more info
 
sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sodium-coupled neutral amino acid transporter 3
Names
N-system amino acid transporter 1
Na(+)-coupled neutral amino acid transporter 3
system N amino acid transporter 1
system N1 Na+ and H+-coupled glutamine transporter

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006841.6NP_006832.1  sodium-coupled neutral amino acid transporter 3

    See identical proteins and their annotated locations for NP_006832.1

    Status: VALIDATED

    Source sequence(s)
    AC002077, BM662099, BP362985, BX537382
    Consensus CDS
    CCDS74940.1
    UniProtKB/Swiss-Prot
    Q99624
    Related
    ENSP00000481301.1, ENST00000614032.5
    Conserved Domains (2) summary
    COG0814
    Location:64486
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    pfam01490
    Location:64491
    Aa_trans; Transmembrane amino acid transporter protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    50205268..50221486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712954.3XP_006713017.1  sodium-coupled neutral amino acid transporter 3 isoform X1

    See identical proteins and their annotated locations for XP_006713017.1

    UniProtKB/Swiss-Prot
    Q99624
    Conserved Domains (2) summary
    COG0814
    Location:64486
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    pfam01490
    Location:64491
    Aa_trans; Transmembrane amino acid transporter protein

RNA

  1. XR_001739987.2 RNA Sequence

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