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SLC38A3 solute carrier family 38 member 3 [ Homo sapiens (human) ]

Gene ID: 10991, updated on 22-Sep-2022

Summary

Official Symbol
SLC38A3provided by HGNC
Official Full Name
solute carrier family 38 member 3provided by HGNC
Primary source
HGNC:HGNC:18044
See related
Ensembl:ENSG00000188338 MIM:604437; AllianceGenome:HGNC:18044
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G17; SN1; NAT1; SNAT3; DEE102
Summary
Enables L-amino acid transmembrane transporter activity. Involved in amino acid transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver (RPKM 98.6) and brain (RPKM 9.7) See more
Orthologs
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Genomic context

See SLC38A3 in Genome Data Viewer
Location:
3p21.31
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (50205271..50221486)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (50234602..50250823)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (50242704..50258918)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene semaphorin 3F Neighboring gene Sharpr-MPRA regulatory region 10077 Neighboring gene G protein subunit alpha transducin 1 Neighboring gene microRNA 5787 Neighboring gene G protein subunit alpha i2 Neighboring gene Sharpr-MPRA regulatory region 8430

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-alanine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-asparagine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-asparagine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-asparagine, sodium:proton antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables L-glutamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-glutamine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-glutamine, sodium:proton antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables L-histidine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-histidine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-histidine, sodium:proton antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables amino acid transmembrane transporter activity TAS
Traceable Author Statement
more info
 
enables neutral amino acid:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in L-alanine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in L-asparagine import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in L-glutamine import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in L-histidine import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in L-histidine transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in amino acid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in amino acid transport TAS
Traceable Author Statement
more info
 
involved_in asparagine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in asparagine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to potassium ion starvation IEA
Inferred from Electronic Annotation
more info
 
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
involved_in glutamine secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glutamine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glutamine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histidine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histidine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of glutamine transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter in response to acidic pH IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sodium-coupled neutral amino acid transporter 3
Names
N-system amino acid transporter 1
Na(+)-coupled neutral amino acid transporter 3
system N amino acid transporter 1
system N1 Na+ and H+-coupled glutamine transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006841.6NP_006832.1  sodium-coupled neutral amino acid transporter 3

    See identical proteins and their annotated locations for NP_006832.1

    Status: VALIDATED

    Source sequence(s)
    AC002077, BM662099, BP362985, BX537382
    Consensus CDS
    CCDS74940.1
    UniProtKB/Swiss-Prot
    Q6IB34, Q99624
    Related
    ENSP00000481301.1, ENST00000614032.5
    Conserved Domains (2) summary
    COG0814
    Location:64486
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    pfam01490
    Location:64491
    Aa_trans; Transmembrane amino acid transporter protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    50205271..50221486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712954.4XP_006713017.1  sodium-coupled neutral amino acid transporter 3 isoform X1

    See identical proteins and their annotated locations for XP_006713017.1

    UniProtKB/Swiss-Prot
    Q6IB34, Q99624
    Conserved Domains (2) summary
    COG0814
    Location:64486
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    pfam01490
    Location:64491
    Aa_trans; Transmembrane amino acid transporter protein

RNA

  1. XR_001739987.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    50234602..50250823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)