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METAP2 methionyl aminopeptidase 2 [ Homo sapiens (human) ]

Gene ID: 10988, updated on 9-Dec-2018

Summary

Official Symbol
METAP2provided by HGNC
Official Full Name
methionyl aminopeptidase 2provided by HGNC
Primary source
HGNC:HGNC:16672
See related
Ensembl:ENSG00000111142 MIM:601870
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAP2; MNPEP; p67eIF2
Summary
The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in testis (RPKM 26.5), lymph node (RPKM 23.7) and 25 other tissues See more
Orthologs

Genomic context

See METAP2 in Genome Data Viewer
Location:
12q22
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (95474046..95515839)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (95867822..95909615)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984545 Neighboring gene RNA, U6 small nuclear 735, pseudogene Neighboring gene ribosomal protein L29 pseudogene 26 Neighboring gene ubiquitin specific peptidase 44 Neighboring gene phosphoglycerate mutase 1 pseudogene 5 Neighboring gene netrin 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Inactivation, recovery and regulation of the phototransduction cascade, organism-specific biosystem (from REACTOME)
    Inactivation, recovery and regulation of the phototransduction cascade, organism-specific biosystemTo terminate the single photon response and restore the system to its basal state, the three activated intermediates in phototransduction, rhodopsin (MII), transducin alpha subunit with GTP bound (GN...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • The phototransduction cascade, organism-specific biosystem (from REACTOME)
    The phototransduction cascade, organism-specific biosystemThe visual pigment (rhodopsin in rods) consists of an 11-cis-retinal (11cRAL) chromophore covalently attached to a GPCR opsin family member via a Schiff base linkage. Upon photon absorption, 11cRAL i...
  • Visual phototransduction, organism-specific biosystem (from REACTOME)
    Visual phototransduction, organism-specific biosystemVisual phototransduction is the process by which photon absorption by visual pigment molecules in photoreceptor cells is converted to an electrical cellular response. The events in this process are p...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
aminopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
aminopeptidase activity TAS
Traceable Author Statement
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
metalloexopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
N-terminal protein amino acid modification IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-methionine modification IDA
Inferred from Direct Assay
more info
PubMed 
protein initiator methionine removal IEA
Inferred from Electronic Annotation
more info
 
protein processing IDA
Inferred from Direct Assay
more info
PubMed 
regulation of rhodopsin mediated signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
methionine aminopeptidase 2
Names
eIF-2-associated p67 homolog
initiation factor 2-associated 67 kDa glycoprotein
peptidase M 2
testicular tissue protein Li 17
NP_001304111.1
NP_001304112.1
NP_001317175.1
NP_006829.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317182.1NP_001304111.1  methionine aminopeptidase 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC018475, AK300836, DW409106
    Consensus CDS
    CCDS81723.1
    UniProtKB/Swiss-Prot
    P50579
    Related
    ENSP00000448169.1, ENST00000546753.5
    Conserved Domains (1) summary
    PTZ00053
    Location:110455
    PTZ00053; methionine aminopeptidase 2; Provisional
  2. NM_001317183.1NP_001304112.1  methionine aminopeptidase 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC018475, AK091730, DW409106
    Consensus CDS
    CCDS81725.1
    UniProtKB/Swiss-Prot
    P50579
    Related
    ENSP00000261220.9, ENST00000261220.13
    Conserved Domains (1) summary
    PTZ00053
    Location:89455
    PTZ00053; methionine aminopeptidase 2; Provisional
  3. NM_001330246.1NP_001317175.1  methionine aminopeptidase 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice junction in the 5' coding region compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is one amino acid shorter compared to isoform 1.
    Source sequence(s)
    AC018475, AK091730, CA450598, DW409106, U13261
    Consensus CDS
    CCDS81724.1
    UniProtKB/Swiss-Prot
    P50579
    UniProtKB/TrEMBL
    F8VQZ7
    Related
    ENSP00000450063.1, ENST00000551840.5
    Conserved Domains (1) summary
    PTZ00053
    Location:106477
    PTZ00053; methionine aminopeptidase 2; Provisional
  4. NM_006838.4NP_006829.1  methionine aminopeptidase 2 isoform 1

    See identical proteins and their annotated locations for NP_006829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC018475, U13261
    Consensus CDS
    CCDS9052.1
    UniProtKB/Swiss-Prot
    P50579
    UniProtKB/TrEMBL
    A0A140VJE3
    Related
    ENSP00000325312.5, ENST00000323666.9
    Conserved Domains (1) summary
    PTZ00053
    Location:107478
    PTZ00053; methionine aminopeptidase 2; Provisional

RNA

  1. NR_133673.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC018475, AK125296

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    95474046..95515839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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