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SCO3231 CDA peptide synthetase II [ Streptomyces coelicolor A3(2) ]

Gene ID: 1098665, discontinued on 9-Sep-2022
  • This record was discontinued.

Summary

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Gene symbol
SCO3231
Gene description
CDA peptide synthetase II
Locus tag
SCO3231
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Streptomyces coelicolor A3(2) (serovar: A3(2))
Lineage
Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group
Also known as
cdaPS2; SCE63.02c
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Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003888.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Miscellaneous features

  • Loc: 3565756-3566910 Pfam match to entry PF00668 DUF4, Domain of unknown function, score 290.10, E-value 2.7e-83
  • Loc: 3567199-3568329 Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 446.50, E-value 2.3e-130
  • Loc: 3567526-3567561 PS00455 AMP-binding domain signature.
  • Loc: 3568576-3568770 Pfam match to entry PF00550 pp-binding, Phosphopante theine attachment site, score 78.00, E-value 5.9e-20
  • Loc: 3568645-3568692 PS00012 Phosphopantetheine attachment site.
  • Loc: 3568813-3569991 Pfam match to entry PF00668 DUF4, Domain of unknown function, score 332.60, E-value 4.3e-96
  • Loc: 3570298-3571446 Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 472.70, E-value 3e-138
  • Loc: 3571723-3571917 Pfam match to entry PF00550 pp-binding, Phosphopante theine attachment site, score 88.00, E-value 1e-22
  • Loc: 3571792-3571839 PS00012 Phosphopantetheine attachment site.
  • Loc: 3571960-3573180 Pfam match to entry PF00668 DUF4, Domain of unknown function, score 326.10, E-value 3.9e-94
  • Loc: 3573487-3574713 Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme, score 428.90, E-value 4.6e-125
  • Loc: 3573871-3573906 PS00455 AMP-binding domain signature.
  • Loc: 3574972-3575163 Pfam match to entry PF00550 pp-binding, Phosphopante theine attachment site, score 71.90, E-value 2.9e-18
  • Loc: 3575041-3575088 PS00012 Phosphopantetheine attachment site
  • Loc: 3575248-3576495 Pfam match to entry PF00668 DUF4, Domain of unknown function, score 87.50, E-value 2.7e-22

General protein information

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Names
CDA peptide synthetase II
NP_627444.1
  • SCE63.02c, cdaPS2, CDA peptide synthetase II, len: 3670 aa; part of the calcium-dependent antibiotic (CDA) biosynthetic cluster from Streptomyces coelicolor. CDA is a peptide antibiotic which is synthesised non-ribosomally by a multifunctional peptide synthetase enzyme. This CDS encodes a subunit of this enzyme and is suspected to be responsible for the addition of 3 amino acids to the peptide antibiotic. This ORF overlaps the upstream (cdaPSI) and downstream (cdaPSIII) ORFs by one base indicating possible translational coupling of all three. Contains four separate Pfam matches to entry PF00668 DUF4, Domain of unknown function (U), three separate Pfam matches to entry PF00501 AMP-binding, AMP-binding enzyme (A) and three separate Pfam matches to entry PF00550 pp-binding, Phosphopantetheine attachment site (P). These Pfam matches cover the full length of the protein in the following order from N to C-terminal U-A-P-U-A-P-U-A-P-U. The first and third Pfam matches to entry PF00501 also contain Prosite matches to PS00455 AMP-binding domain signature. All three Pfam matches to entry PF00550 also contain Prosite matches to PS00012 Phosphopantetheine attachment site.

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003888.3 Reference assembly

    Range
    3565723..3576735
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_627444.1 CDA peptide synthetase II [Streptomyces coelicolor A3(2)]

    Status: REVIEWED

Nucleotide Protein
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